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Nicolas Manel Lab

@manellab.bsky.social
292 followers 83 following 55 posts

Institut Curie, Paris, France minilien.curie.fr/ejggfa

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Nicolas Manel Lab @manellab.bsky.social · 08/09/2026
Our highlights of the @embo.org workshop Pathogen Immunity & Signaling 2026 just came out in @natimmunol.nature.com! www.nature.com/articles/s41...
nature.com
New frontiers in pathogen immunity - Nature Immunology
The EMBO workshop ‘Pathogen Immunity and Signaling’ was held from 8 to 11 June 2026 in Leiden, the Netherlands, bringing together 175 participants from 25 countries to discuss the latest advances in a...
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Nicolas Manel Lab @manellab.bsky.social · 24/08/2026
Exciting new publication from the Zierhut lab. Among the many cool things they found already with the reporter: Activating cGAS ≠activating STING, with regards to intercellular signaling dynamics. This has far reaching implications for cancer immunotherapy.
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Nicolas Manel Lab @manellab.bsky.social · 14/08/2026
(1/6) 🔥🔥 Double hot for two new papers by our PhD graduate Adriana Loverre! 1️⃣ A dendritic cell autophagy-neutrophil axis limits intratumoral STING immunotherapy 📖 Science Immunology We uncover an unexpected mechanism limiting the efficacy of intratumoral STING therapy. 🧵👇
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Nicolas Manel Lab @manellab.bsky.social · 25/07/2026
We also released the OST-Sting-flox mouse strain, originally developed by Bernard Malissen. It combines an N-terminal Strep-tagged STING allele with a floxed cassette and is now available through The Jackson Laboratory. www.jax.org/strain/041165
jax.org
041165 - STING-OST[fl] Strain Details
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Nicolas Manel Lab @manellab.bsky.social · 25/07/2026
Shout out to say that our GFP-cGAS knock-in mouse is now available through the MMRRC. This strain is particularly useful for investigating nucleic acids associated with cGAS. www.mmrrc.org/catalog/sds....
mmrrc.org
MMRRC:076001-UCD
Strain Detail Sheet for STOCK <i>Cgas<sup>tm1Ciphe</sup></i>/Mmucd
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Reposted by Nicolas Manel Lab
innate-immuno.bsky.social @innate-immuno.bsky.social · 16/07/2026
🚨Novel Concepts in #Innate_Immunity #conference (NCII) 18-20 May 2027 speaker list is out: 🚨 Join us @uni_tue to hear @audeber.bsky.social, @drusqui.bsky.social @soyonhonglab.bsky.social, @laemmermann-lab.bsky.social, @manellab.bsky.social, @v-hornung.bsky.social and many others! Link👇
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Nicolas Manel Lab @manellab.bsky.social · 11/06/2026
#EMBOsignaling2026 last day already! Full house for a terrific panel session with editors @science.org @cp-immunity.bsky.social @jem.org @cp-cellreports.bsky.social @embopress.org @plosbiology.org @cp-trendsimmuno.bsky.social @cp-cellhostmicrobe.bsky.social Science Signaling
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Nicolas Manel Lab @manellab.bsky.social · 08/06/2026
#EMBOsignaling2026 First Keynote by Mihai Netea on trained immunity! The level of science was inversely proportional to the size of the screen! Moving to the proper Naturalis auditorium for the workshop tomorrow. Stay tuned!
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Nicolas Manel Lab @manellab.bsky.social · 08/06/2026
@embo.org #EMBOsignaling2026 welcoming the participants now!
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Nicolas Manel Lab @manellab.bsky.social · 22/04/2026
Few more seats released for the upcoming #EMBO workshop #Pathogen #Immunity and #Signaling in Leiden, Netherlands, 8-12 June. Awesome meeting, great crowd, reasonable price, terrific venue. Only good reasons to join! meetings.embo.org/event/26-pat...
meetings.embo.org
Pathogen Immunity and Signalling
Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…
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Nicolas Manel Lab @manellab.bsky.social · 17/03/2026
🧬🇯🇵 Registrations are now open for the 2026 Nucleic Acid Immunity Meeting in Nara, Japan. Fantastic line‑up of invited speakers already. www.ifrec.osaka-u.ac.jp/nais26/index...
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Nicolas Manel Lab @manellab.bsky.social · 03/02/2026
Excited to participate in the event and share our ongoing work in this space. Join!
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Nicolas Manel Lab @manellab.bsky.social · 26/01/2026
⚠️ One week left to submit your abstract to the 2026 @embo.org Workshop on #Pathogen #Immunity and #Signaling. 👇
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Nicolas Manel Lab @manellab.bsky.social · 23/01/2026
🌈 Glory to the international labs. This is our new weekly routine. 👇
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Nicolas Manel Lab @manellab.bsky.social · 16/01/2026
The concept of antagonisitic pleiotropy in aging (well established for senescence) revisited for the case of infectious diseases. 👇
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Nicolas Manel Lab @manellab.bsky.social · 26/11/2025
@globalimmuno.bsky.social replay here: www.youtube.com/watch?v=mFr4... Enjoy. Thanks to the wonderful team for making this happen.
youtube.com
"Centromeres reimagined in the immune system" by Dr. Nicolas Manel
YouTube video by GLOBAL IMMUNOTALKS
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Reposted by Nicolas Manel Lab
Global Immunotalks @globalimmuno.bsky.social · 26/11/2025
Not to be missed! Our next #globalimmuno talk, today Wednesday, November 26th at 9am PST, noon EST, 5pm GMT by Dr. Nicolas Manel. Title: “Centromeres reimagined in the immune system” ZOOM LINK: us06web.zoom.us/webinar/regi... LIVE ON YOUTUBE: www.youtube.com/@GLOBALIMMUN...
us06web.zoom.us
Welcome! You are invited to join a webinar: GLOBAL IMMUNOTALKS: Virtual immunology seminar series . After registering, you will receive a confirmation email about joining the webinar.
Subscribe to our YouTube channel to stay updated and participate in the discussions: https://www.youtube.com/c/GLOBALIMMUNOTALKS We now offer: ✅ Live streaming on YouTube (in addition to Zoom) ✅ Asyn...
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Nicolas Manel Lab @manellab.bsky.social · 24/11/2025
🔥In two days!
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Nicolas Manel Lab @manellab.bsky.social · 06/11/2025
You bet. Thanks so much to the amazing @erc.europa.eu, the panel members and the reviewers!
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Nicolas Manel Lab @manellab.bsky.social · 04/11/2025
🔥👇 The place to be.
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Reposted by Nicolas Manel Lab
Iannacone Lab @iannaconelab.bsky.social · 18/10/2025
Join us for this exciting meeting! @embo.org Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands meetings.embo.org/event/26-pat...
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Nicolas Manel Lab @manellab.bsky.social · 07/10/2025
🔥 Mark the date! 🗓️ Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived. Terrific roster of speakers, many spots for talks, spectacular venue in Leiden. Submit your abstract. Join us on 8 – 11 June 2026. meetings.embo.org/event/26-pat...
meetings.embo.org
Pathogen Immunity and Signalling
Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…
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Nicolas Manel Lab @manellab.bsky.social · 03/10/2025
Fantastic seminar today by Norbert Pardi from @upenn.edu who did the pioneering work with Katalin Kariko and Drew Weissman to unlock mRNA nanoparticules. mRNA nanoparticules are the therapeutics of tomorrow!
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Nicolas Manel Lab @manellab.bsky.social · 04/09/2025
🔥Really cool work by our neighbors @dfachinetti.bsky.social together with Stanford's only @naltemose.bsky.social showcasing the ability to tune DNA methylation specifically in centromeric DNA, in turn affecting the identity and functionality of centromeres.
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Nicolas Manel Lab @manellab.bsky.social · 07/08/2025
Erika Valeri & Moriz Gaidt @impvienna.bsky.social put together a very nice "Spotlights" piece in the latest issue of Molecular Cell @cp-molcell.bsky.social about the antiviral defense system VICAR and some of the avenues of research it opens. 🙏 to the authors www.cell.com/molecular-ce...
cell.com
DIY innate immune sensing: Crafting fresh DNA to detect viruses
The innate immune receptor cGAS is geared toward detecting DNA from pathogens. In a recent Cell publication, Lahaye et al. discovered that viral infection triggers de novo synthesis of self-DNA-activa...
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Nicolas Manel Lab @manellab.bsky.social · 05/08/2025
Thrilled to be part of the late 2025 roster of @globalimmuno.bsky.social See you all on November 26th! Thanks so much to the organisers for putting this together.
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Nicolas Manel Lab @manellab.bsky.social · 02/08/2025
Really cool highlight of our work @cp-cell.bsky.social describing VICAR, a novel antiviral defense system in humans, where centromeres take the center stage. Thank you so much Fumiko @esashilab.bsky.social for your insightful review and the beautiful working model.
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Reposted by Nicolas Manel Lab
Esashi Lab @esashilab.bsky.social · 02/08/2025
Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social‬
rdcu.be
Centromeres as minefields: host–virus warfare
Cell Research - Centromeres as minefields: host–virus warfare
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Nicolas Manel Lab @manellab.bsky.social · 17/07/2025
Happy to let you know that the plasmids (except one, pending QC) from our study describing the VICAR antiviral defense system are now available through @addgene.bsky.social here: www.addgene.org/browse/artic... Thanks @addgene.bsky.social for making this possible!
addgene.org
Addgene: Manel lab plasmids 2025
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Nicolas Manel Lab @manellab.bsky.social · 13/06/2025
Trans...genes! Celebrating upcoming publication from @audeber.bsky.social and Enzo Poirier at the unique Learning Center Institute in Paris
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Nicolas Manel Lab @manellab.bsky.social · 02/06/2025
Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...
cell.com
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...
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Reposted by Nicolas Manel Lab
IGMM-Montpellier @igmm-montpel.bsky.social · 28/05/2025
📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️ application.igmm.cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
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Nicolas Manel Lab @manellab.bsky.social · 29/05/2025
How does a cell detect infection by a DNA virus in its nucleus?
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Nicolas Manel Lab @manellab.bsky.social · 26/05/2025
Check out Randmice 2.0 from our colleagues @ Stimunity Biotech. It became an essential tool for us to optimize animal randomization for in vivo experiments. And it's free! randmice.com
randmice.com
Randmice - Optimize animal randomization
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Nicolas Manel Lab @manellab.bsky.social · 21/05/2025
Soren Paludan @civia-aarhus.bsky.social kicks off a wonderful 2-day workshop on antiviral host defense. Looking forward to catching up will all the speakers and participants!
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Nicolas Manel Lab @manellab.bsky.social · 27/04/2025
So thrilled to participate in the #EMBO workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including @dfachinetti.bsky.social
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Reposted by Nicolas Manel Lab
Iannacone Lab @iannaconelab.bsky.social · 08/03/2025
🚨 New EJI-EFIS Prize for ECRs! 🚨 🏆 €5,000 award for the best research article in EJI by an Early Career Researcher! 🎤 Winner presents at ECI + receives an EFIS–EJI travel grant! 🔗 Apply now: onlinelibrary.wiley.com/page/journal... #ECR #Immunology #EJI #EFIS #ScienceFunding
onlinelibrary.wiley.com
European Journal of Immunology: EJI-EFIS Prize for the ECR Article of the Year
EJI and EFIS are thrilled to announce a new prize honoring Early Career Researchers (ECRs) whose work is published in EJI. This initiative aims to showcase the next generation of immunologists and encourage them to submit their excellent research to EJI.
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Nicolas Manel Lab @manellab.bsky.social · 07/03/2025
@sufs-paris-rp.bsky.social #StandUpForScience felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!
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Nicolas Manel Lab @manellab.bsky.social · 26/02/2025
#Macrophages literally eat and live of dead #bacteria, while live bacteria stimulate inflammation. 🦠 viability is sensed by an mTORC1 metabolic switch. Superb tour-de-force study @nature.com by the Garaude lab in Bordeaux, with help from @sanderlab.bsky.social www.nature.com/articles/s41...
nature.com
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
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Fondation ARC pour la recherche sur le cancer @fondationarc.bsky.social · 24/02/2025
📢 En 2025, nous renouvelons notre appel à projets « Passerelle » afin de soutenir des chercheurs non statutaires préparant les concours à un poste de chercheur au sein d’un EPST français. 🏆 Les lauréat(e)s recevront un soutien de 100 000 € pour un an. 👉 urlz.fr/pR3x
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Nicolas Manel Lab @manellab.bsky.social · 11/02/2025
Unexpected conservation: Rick Rubin interviews Richard Feynman. Loving this chat btwn 2 titans, defying the laws of time. Plenty of cool topics: curiosity, solving 'simple' problems, avoiding admin duties, teaching != research, religion, social studies.... www.tetragrammaton.com/content/rich...
tetragrammaton.com
Richard Feynman - Tetragrammaton
52m 11.30.24
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Reposted by Nicolas Manel Lab
Rebsamen Lab @UNIL @rebsamenlab.bsky.social · 28/01/2025
Confirmed speakers: A. Ablasser L. Andreeva @audeber.bsky.social @jelenalab.bsky.social V. Dixit @v-hornung.bsky.social B. Lemaitre O. Majer @manellab.bsky.social E. Miao @oliveiramann.bsky.social M. Pasparakis @inflammasomelab.bsky.social @sparrerlab.bsky.social R. Vance @lozanzi.bsky.social
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Nicolas Manel Lab @manellab.bsky.social · 27/01/2025
On veut du fric pour la recherche publique ! Mr le Ministre présentait ses voeux au Collège de France, on était là.
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Nicolas Manel Lab @manellab.bsky.social · 14/01/2025
Showcasing this exciting paper from our good friends Fachinetti lab @institutcurie.bsky.social. #Centromere inactivation triggers #senescence: mis-segregated chromosomes deform the nuclear envelope and activate TORC2-ATR. We helped with #cGAS and some key suggestions. doi.org/10.1038/s415...
doi.org
Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
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