Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...

Thrilled to share that our latest work has just been published in Gut 🚀 We show that donor intrahepatic microbial DNA signatures, detected in organ preservation solution, can predict post-transplant o...

Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...