BOSTON, MA [Sept. 23, 2026] — Our understanding of how cells interact with each other has been driven for decades by the central concept of receptor-mediated

Fascinated by evolution and driven by curiosity, Malik studies everything from viruses to Drosophila and, like his research subjects, is constantly reinventing himself.

TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

How cumulative environmental allergen exposures are encoded by peripheral sensory neurons to shape immune responsiveness is unclear. Zhu et al. show that protease allergens induce an mTORC1-dependent,...

Nature Reviews Immunology, Published online: 24 August 2026; doi:10.1038/s41577-026-01351-wThe discoveries that have transformed immunology often seem obvious in retrospect. Yet none began as an inevitable destination. They began with observations that did not fit, assumptions that somebody challenged, or questions that nobody yet realized were important. Discovery was the outcome. Surprise was the process.

Nature Reviews Immunology - Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen...

Lipids generated by oxidative stress and their effects on immunity and cancer are reviewed.

The Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of pathogen sensing, signalling and effector...

Pereira da Costa et al. define CXCR4 as a marker of dendritic cell activation in the steady state and in cancer, which is absent in activation elicited by Toll-like receptors or type I interferon rece...

Dendritic cells (DCs) can acquire distinct functional states. To examine how different DC states orchestrate anti-tumor immunity, Koufaki et al. develop mouse models to label and ablate CCR7+ DCs and ...

How does the body recognize viral infection? How do viruses engage the immune system during replication? These seemingly simple questions led me to study pattern recognition, a concept first proposed ...

Innate immune recognition of bacteria is thought to center on cell-surface or endosomal pattern recognition receptors such as TLRs. Ragland et al. identify an intraphagosomal cyclic dinucleotide (CDN)...

Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...

B cells are a critical adaptive immune cell type in the development of TH17 cell–mediated experimental autoimmune encephalomyelitis.

Robust inflammatory responses to viral infection are mediated by immune cell populations, including monocytes and dendritic cells. However, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...

This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular p...

Influenza pandemics are often traced back to the spillover of avian influenza A viruses (IAVs) to humans. However, barriers against IAV transmission remain elusive. We demonstrated human stimulator of...

Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr...

Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.

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Cell has an opening for a full-time scientific editor. If you are a passionate, mission-driven team player who loves thinking broadly about science and wants to have a positive impact, we invite you t...

Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...

Some tips for composing and making your new NIH biosketch not look like garbage

IMMUNOLOGY2026™ is the 109th annual meeting of the American Association of Immunologists, April 15-19, 2026 in Boston, MA.

While much is known about the identity and regulation of cytokine-producing cells, the cell types that respond to cytokines remain largely uncharacter…

Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...

Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!

Immunologists have long studied how our body fights pathogens, but the precise patterns of molecules required to trigger an immune response weren’t fully understood. As a PhD student, Anh Cao took the...

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CD27 agonism enhances vaccine-induced CD4 T cell responses, enabling durable antitumor immunity not entirely dependent on CD8 T cells.