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JelenaBezbradicaLab

@jelenalab.bsky.social
255 followers 229 following 11 posts

Professor of Immunology at the University of Oxford. Innate sensing and signalling in macrophages. Inflammasomes. Signalling crosstalk in inflammation. www.kennedy.ox.ac.uk/research/resea…

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JelenaBezbradicaLab @jelenalab.bsky.social · 20/10/2025
Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase.bsky.social from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!
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JelenaBezbradicaLab @jelenalab.bsky.social · 17/10/2025
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw
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Lynn B. Dustin @lynndustin.bsky.social · 28/06/2025
Congratulations to newly minted Dr. Esther L. Jones @estherlj.bsky.social on her successful DPhil viva! A great collaborative project between the L. Dustin and Jelena Bezbradica @jelenalab.bsky.social labs. Many thanks to examiners Irina Udalova @udalovalab.bsky.social and Menna Clatworthy.
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Dr. Sunny Shin @sunnyshinlab.bsky.social · 17/06/2025
Excited to share that our paper examining how GM-CSF potentiates cytokine responses in human monocytes during bacterial infection is now online at the @asm.org journal Infection & Immunity! Congrats to @vvazquez.bsky.social, @mikelhaggadone.bsky.social, & co-authors! journals.asm.org/doi/full/10....
journals.asm.org
GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection | Infection and Immunity
Respiratory infections are a leading cause of morbidity and mortality worldwide, as evidenced by the COVID-19 and tuberculosis pandemics (1, 2). More than 4 million people die annually due to respirat...
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Dr. Sunny Shin @sunnyshinlab.bsky.social · 02/04/2025
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
elifesciences.org
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JelenaBezbradicaLab @jelenalab.bsky.social · 08/03/2025
Elegant work by @jkagan1.bsky.social and team on identifying how innate immune receptor Caspase 11 recognises molecular patterns in LPS and self lipids.
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Ivan Zanoni @lozanzi.bsky.social · 07/03/2025
#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!
science.org
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity
ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.
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JelenaBezbradicaLab @jelenalab.bsky.social · 07/03/2025
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
science.org
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
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Rebsamen Lab @UNIL @rebsamenlab.bsky.social · 28/01/2025
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland. Registrations open March 1 - Attendance limited to 150 participants. More info: wp.unil.ch/immunobiolog... #ImmunoSky
wp.unil.ch
Symposium immunobiology
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ilesla.bsky.social @ilesla.bsky.social · 16/01/2025
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.
iles.web.ox.ac.uk
How to Apply and Funding
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Madelon de Jong @mdejong.bsky.social · 05/01/2025
Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯
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JelenaBezbradicaLab @jelenalab.bsky.social · 08/01/2025
Ok, let's start here on @bsky.app by reposting this truly outstanding paper by @lozanzi.bsky.social and colleagues!
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