Complement component 1q (C1q), the initiator of the classical complement cascade, mediates synaptic elimination in development and disease, yet the triggers for its deposition on synapses remain uncle...

Compagnion et al. show that TDP-43 loss in microglia causes myelin defects, oligodendrocyte precursor cell imbalance and motor deficits in mice. They identify TDP-43 as a regulator of the TREM2-DAP12 ...

Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability...

The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenation reprogramming, Ei-mutant APP expression in the context of Alzheimer’s disease, and behavioral rescue in depression through Ei-Tph2-mediated neuromodulation.

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

The authors found that the Alzheimer’s disease-associated protein tau, widely considered pathogenic when hyperphosphorylated, has a natural function as part of the innate immune system in the brain an...

Critical Thinking AI for constructive criticism and science evaluation

Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...

The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...

The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...

Glia–neuron interactions are highly complex. Glial cells can sense and modulate different aspects of neuronal activity. Here in Caenorhabditis elegans, the authors show that early aged sensory neurons...

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that microglial loss is linked to r...

Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here, we discuss emerging evidence that oligodendrocytes may directly contribute to ...

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The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.

Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…

While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.

Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

Sex and gender research could lead to better, more equitable treatments — if it is allowed to continue without political interference.

Nature Reviews Neurology, Published online: 14 April 2025; doi:10.1038/s41582-025-01071-0Sex and gender influence the entire healthcare ecosystem of Alzheimer disease (AD). In this Review, Castro-Aldrete et al. present a holistic view of sex and gender in AD, and discuss how these factors affect research and policy efforts to improve AD prevention, diagnosis and treatment.

How Trump's Cuts Are Crippling American Innovation and Ceding the Future

Removing the top leadership at NIAID, NIH and other health agencies including CDC and FDA will damage America’s position as a leader in groundbreaking research in disease prevention and treatment.

Layoff notices began arriving early Tuesday for thousands of employees of HHS and its subsidiary agencies, with as many 10,000 workers potentially expected to be hit by the cuts.

Thousands of CDC employees who worked on things like preventing HIV and lead poisoning have been told they were subject to a reduction in force. Experts say people will die.

YouTube video by UCI GenPALS

UCI GenPALS (Genomics Practical Applications and Learning Seminar) is a community of genomics researchers at the University of California, Irvine. We upload videos of our interactive seminars that we ...

Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.

We developed two mouse strains enabling loxP recombination in either all myeloid cells or inducibly in disease-associated microglia (DAMs). DAMs are a subset of plaque-associated microglia (PAMs)...

What is RISE? RISE is a research study being conducted by Emory University, the University of Nevada, Las Vegas, and the University of Tennessee, Knoxville. RISE includes a registry created […]

Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organis...

White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...

Background Alzheimer’s disease (AD) disproportionately and uniquely affects females, and these sex differences are further exacerbated by the presence of Apolipoprotein (APOE) ε4 alleles, the top gene...

In Alzheimer’s disease (AD), microglia form distinct cellular aggregates that play critical roles in disease progression, including Aβ plaque-associated microglia (PaM) and the newly identified coffin...