Objective The ketogenic diet (KD) is a high-fat, low-carbohydrate intervention widely used to treat drug-resistant epilepsy, thought to reduce seizures through a combination of metabolic, neuronal, ...

Brain activity is highly regulated by GABAergic activity, which can suppress neuronal excitability and synaptic integration. Tonic GABAergic conductan…

Research from the Buck Institute reveals that the protective APOE2 variant, already associated with exceptional longevity and reduced Alzheimer's risk, keeps human brain cells genomically stable and r...

A California bill would give voters the chance to vote on whether the state should create a $23 billion bond that would be used to award grants to university researchers.

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability of hippocampal neurons and can be reversed by targeting Nell2.

Young, cognitively normal APOE4 mice display hippocampal network hyperactivity that predicts later memory decline. This phenotype is driven by neuronal APOE4 expression, which causes hyperexcitability...

The main function of mitochondria is to generate ATP by oxidizing pyruvate to CO2. Rauseo et al. show that matrix pyruvate is also converted to lactate, which is released to the cytosol via the MPC to...

Topography is a well-described and well-known concept for cortical organization in primary sensory and motor cortices of mammalian brains. Similar ...

ALT: a man with glasses and a mustache is wearing a white shirt and says yes .

INTRODUCTION Overexpression of the low-density lipoprotein receptor (LDLR) is known to decrease apolipoprotein E (APOE) levels and alleviate amyloid beta (Aβ) pathology. We hypothesized that inhibit...

Research Technician I

CRISPR screens in iPSC-derived neurons reveal that the E3 ubiquitin ligase CRL5SOCS4 ubiquitinates tau, that CUL5 expression is correlated with resilience in human Alzheimer’s disease, and that electr...

npj Dementia - Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss

Ralhan et al. show that ApoE2 and ApoE3 Christchurch on lipid particles efflux oxidized phospholipids from neurons via the ABCA7 transporter. This reduces the burden of oxidized lipids, which improves lysosomal function and protects neurons from ferroptosis.

Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...

INTRODUCTION The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu.....

Asymptomatic Alzheimer’s disease (AsymAD) refers to individuals who, despite exhibiting amyloid-β plaques and tau pathology comparable to Alzheimer’s disease (AD), maintain cognitive performance simil...

Nature Metabolism, Published online: 04 November 2025; doi:10.1038/s42255-025-01390-yBarnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory responses.