iiinova — where your digital self keeps evolving

Reposted by @alexlish.bsky.social

Young-Pearse Lab @typlab.bsky.social · 25/08/2025

Best of luck today to @alexlish.bsky.social on her first day at Novartis! We will miss her greatly but look forward to seeing all of the fabulous things she accomplishes in her new scientific endeavors!

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Reposted by @alexlish.bsky.social

Selina Wray @selinawray.bsky.social · 29/07/2025

I’m a huge fan of the work done by @typlab.bsky.social - so it was great to have the opportunity to write a preview of their work describing an in vitro triculture model of Alzheimer’s (with @celarber.bsky.social & Tatiana). Check it out & go read their paper! www.sciencedirect.com/science/arti...

sciencedirect.com

Reconstructing Alzheimer’s disease one cell type at a time using in vitro tricultures

In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes,…

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Reposted by @alexlish.bsky.social

Young-Pearse Lab @typlab.bsky.social · 31/07/2025

Honored to have our work featured!Huge thanks for highlighting our triculture Alzheimer’s model!

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Young-Pearse Lab @typlab.bsky.social · 31/05/2025

🎓Congratulations to our incredible grads! 🎉 Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂 We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish.bsky.social

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Young-Pearse Lab @typlab.bsky.social · 15/05/2025

Excited to see our recent study featured on Alzforum! Thank you for highlighting our new study on how AD risk variants at the CLU locus lower astrocytic clusterin, disrupt neuroimmune crosstalk, and drive synapse loss. Read the full story here!

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Alzheimer’s Risk Variants Leave Astrocytes CLUless | ALZFORUM

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alexlish.bsky.social @alexlish.bsky.social · 30/04/2025

Thrilled to share my first first-author paper is out @cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here www.sciencedirect.com/science/arti...

sciencedirect.com

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density

Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…

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Young-Pearse Lab @typlab.bsky.social · 28/02/2025

Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!

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