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Reposted by Ari Molofsky

sbierski-kind.bsky.social @sbierski-kind.bsky.social · 14/03/2026

So glad to see this finally being published! Huge thanks to the whole team, and a special shout-out to @arimolofskylab.bsky.social for the incredible mentorship! Check out how the adventitial fibroblast-ILC2 niche restrains liver fibrosis... www.science.org/doi/10.1126/...

science.org

Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches

T2Ls and T3Ls colocalize in liver fibroblast niches; T2L loss drives T3L expansion and worsens fibrosis.

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Ari Molofsky @arimolofskylab.bsky.social · 15/10/2025

Beautiful summary and spot on with the graphical abstract!

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Reposted by Ari Molofsky

Nathan Ewing-Crystal @nathanec.bsky.social · 03/09/2025

1/ Thrilled to share that my PhD thesis work is now out in its final form @nature.com! A huge thanks to the entire team (which has only grown since we first put this out), our peer reviewers, the Nature editorial team, and the incredible @arimolofskylab.bsky.social. www.nature.com/articles/s41...

nature.com

Dynamic fibroblast–immune interactions shape recovery after brain injury - Nature

Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local im...

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Reposted by Ari Molofsky

Anna Molofsky Lab @annamolofskylab.bsky.social · 07/03/2025

Agree! An honor to receive the Bowes award together with @kampmann.bsky.social - a testament to the incredible collaborations at @ucsfhealth.bsky.social that make our science possible!

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Reposted by Ari Molofsky

Bella Rauch @rauchlab.bsky.social · 01/03/2025

The study section I sit on (Innate Immunity B) will be rescheduled to April. Just putting this out there since folks have been getting no notifications about whats going on with their grants.

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Reposted by Ari Molofsky

Justin Eyquem @j-eyquem.bsky.social · 04/02/2025

3/ With a single IV injection, Ark313 achieves gene delivery in up to 25% of T cells, in both circulating and tissues, including tissue resident memory! This unlocks new possibilities for studying T cell function in their natural niche. (🙏 to Roberto Ricardo Gonzalez and @arimolofskylab.bsky.social)

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Ari Molofsky @arimolofskylab.bsky.social · 17/01/2025

Cool perspective on the role of brain extracellular matrix!

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Reposted by Ari Molofsky

Sarah Ross @sarahhross.bsky.social · 11/12/2024

In Nov '24: ILC2s promoted formation of inhibitory synapses during a period of postnatal brain development in mice. This influenced social behaviour in the adult mice. buff.ly/49yODYd From @annamolofskylab.bsky.social and @arimolofskylab.bsky.social et al #Neuroimmunology @science.org

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Reposted by Ari Molofsky

Kat Mayer-Barber,PhD @mayerbarber.bsky.social · 06/12/2024

Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9

Graphical summary of our paper. In mice, prior lower airway exposure to diverse inflammatory stimuli, including chronic bacterial infections such as M. tuberculosis, acute bacterial infections such as pulmonary S. aureus, viral infections such as Influenza A, type-II allergic responses such as the OVA-Alum model, activation of pulmonary TLR9 by CpG or pulmonary TLR1/2 by Pam3CSK4
leads to reduced viral burden upon subsequent infection with SARS-CoV-2 (SCV2). (2) This SCV2 restriction occurs prior to induction of SCV2-specific adaptive immune responses
and is mediated through innate immune responses, including the induction of IFN-I, TNFα and IL-1 and sustained changes to the TRM (Tissue resident macrophage) cellular
compartment and the pulmonary epithelium. (3) Innate cytokine and TLR signaling to both recruited immune cells and the pulmonary epithelium creates a microenvironment in the
lung that limits early replication of SCV2. IFN-I signaling to pulmonary ECs (epithelial cells) increases expression of interferon-stimulated genes, that likely cell-intrinsically limit viral
replication. TNF- or IL-1 suppress SCV2 independently of IFN-I signaling. TNF acts exclusively through radio-resistant cell types such as the lung epithelium, whereas IL-1 affords
control both direct and indirectly, through either stromal and hematopoietic cell types, to restrict overall early SCV2 burden.

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Reposted by Ari Molofsky

Anna Molofsky Lab @annamolofskylab.bsky.social · 17/11/2024

ok- sci bsky - trying this out. our latest paper with @arimolofskylab.bsky.social shows that "allergic" immune cells (ILC2s) have a healthy function in developing brain: formation of inhibitory synapses - key tuners of brain activity www.science.org/stoken/autho...

science.org

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior

The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. I...

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