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Margaret Gadek

@margaretgadek.bsky.social
75 followers 97 following 2 posts

UCSF MDPhD student studying the X chromosome UChicago trained | Minnesota raised Often found walking around the city or listening to the radio in the park she/her

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Reposted by Margaret Gadek
Dena Dubal @denadubal.bsky.social · 12/04/2025
Congratulations @margaretgadek.bsky.social on a wildly successful PhD! On to the MD!
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Reposted by Margaret Gadek
Science Magazine @science.org · 11/03/2025
A new #ScienceAdvances study examines how aging-driven reactivation of genes in the silent X chromosome affects cognitive decline in female mice. #WomensHealth scim.ag/3DxPjl7
scim.ag
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
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Reposted by Margaret Gadek
Science Magazine @science.org · 11/03/2025
A special issue on #WomensHealth in #ScienceAdvances highlights a growing wave of research focusing on women’s unique biological and psychological experiences. Learn more: scim.ag/3R59fPe (THREAD 🧵)
Science Advances’ special issue on women’s health highlights a growing wave of research focusing on women’s unique biological and psychological experiences. Articles cover a range of studies from the interplay between menopause and Alzheimer’s risk to the menstrual cycle’s influence on the brain-heart connection. It also describes the opportunities pregnancy provides to research aspects of both physical and mental health. By prioritizing women’s unique physiological and psychological experiences, research can expand the frontiers of knowledge in ways that benefit everyone.
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Margaret Gadek @margaretgadek.bsky.social · 06/03/2025
Thanks for sharing our work! The second X chromosome is a fascinating part of our genome.
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Reposted by Margaret Gadek
Dena Dubal @denadubal.bsky.social · 06/03/2025
"We could all use a little more X!" Thrilled our new study is out. Aging "wakes up" the silent X chromosome in the female brain - and this contributes cognitive resilience. Spearheaded by @margaretgadek.bsky.social in Science Advances. www.science.org/doi/10.1126/...
science.org
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
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Margaret Gadek @margaretgadek.bsky.social · 05/03/2025
Our new Science Advances paper reveals activation of the silent X chromosome as a mechanism of female resilience in cognitive aging www.science.org/doi/10.1126/... Many thanks to @denadubal.bsky.social for your mentorship on this project!!
science.org
Aging activates escape of the silent X chromosome in the female mouse hippocampus
Aging activates the silent X chromosome, increasing escape expression, and potentially cognitive resilience, in the female mouse.
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