Share stories, raise awareness and campaign with everyone affected by multiple sclerosis (MS). The theme for 2024-2026 is diagnosis, support the My MS Diagnosis campaign today. World MS Day is coordin...

How cancer cells subvert immunity to colonize the lymph node remains unclear. Terasaki et al. uncover that lymph node metastasis may be driven by an immune-to-cancer mitochondria transfer axis that im...

INTRODUCTION Microglia are macrophage-like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derive...

Abstract. Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However,

Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Neurons are specialized cells designed to process information and transmit it, often across long distances. In many neurons, the axonal volume far exceeds the somato-dendritic volume, creating a need ...

Nature Metabolism - EMito-Metrix enables automated evaluation of mitochondrial morphology across species

The number and diversity of inhibitory neurons (INs) increased substantially during mammalian brain evolution. However, the generative mechanisms of the vast repertoire of human INs remain elusive. We...

npj Systems Biology and Applications - Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.

DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynami...

Mito-nuclear communication extends beyond the cell. This review explores how mitochondrial stress engages UPRmt and ISRmt signaling and scales through mitokines and neural circuits to shape systemic p...

Meichsner et al. review recent insights into mitochondria as dynamic signaling hubs. The authors describe how structural plasticity and interorganellar communication enable mitochondria to serve as bo...

Background and ObjectivesA pilot trial of the antioxidant lipoic acid (LA) in secondary progressive multiple sclerosis (MS) demonstrated a reduction in the whole-brain atrophy, suggesting neuroprotect...

Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...

Single-cell proteomics maps protein dynamics in the developing human brain.

Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced

Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced

Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced

This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

Polyamines prevent the action of kinases on acidic phosphorylatable motifs in spliceosomal proteins, thus providing a mechanism for metabolite-mediated regulation of alternative splicing in cells.

Lipid droplets have key roles in energy storage and lipid metabolism. This Review discusses tools used for assessing lipid droplet heterogeneity, and how their heterogeneous composition and interactio...

PU.1low CD28-expressing microglia may act as suppressive cells in Alzheimer’s disease, mitigating its progression by reducing neuroinflammation and amyloid plaque load, indicating potential immunother...

Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.  &nbs...

The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Liu et al. reveal that neutrophil extracellular traps (NETs) serve as markers of post-stroke emotional disorders. The infiltration of NETs into the brain parenchyma leads to the morphological and func...

The recent developments in artificial intelligence (AI) have created both intrigue and apprehension in the world of research. In this Viewpoint, we asked 12 experts in the field of metabolism to share...

The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.

Accumulating evidence suggests that both innate and adaptive immunity play crucial roles in combating Alzheimer’s disease (AD). Specifically, enhancing the homing of monocyte-derived macrophages to th...

We previously reported that T96K is a gain-of-function mutation in TREM2 based on its ability to increase ligand-dependent activation. Here, we show t…

An automated nanoprobe system performs label-free mitochondrial sampling in living cells.

Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?

Microglia, the brain’s innate immune cells, can adopt a wide variety of activation states relevant to health and disease. Dysregulation of microglial activation occurs in numerous brain disorders, and...