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Subhojit Roy MD, PhD

@roylab-ucsd.bsky.social
402 followers 271 following 388 posts

Science & Music. Sometimes funny. www.roylab.org www.youtube.com/@pandemicmelodica

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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 02/10/2026
Best way for #AI to destroy most of humanity will be just to block human access to AI in a few years. Then only the Luddites will rule the earth. Remember these words.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 01/10/2026
Unsolicited observation and probably I shouldn't say this. But lots of smart young people doing derivative and/or non-mechanistic projects that will ultimately be unsatisfying. Get a second opinion from a(nother) trusted mentor folks!
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 01/10/2026
Baldwin's comment on "talent" is very relevant for scientists. I know because I don't have any.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 29/09/2026
There are worse ways to prepare for a talk. #janeliafarms
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 27/09/2026
Park in DC that only allows plant life...and maybe prokaryotes
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 25/09/2026
lol: www.fiercebiotech.com/biotech/acad...
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Reposted by Subhojit Roy MD, PhD
Journal of Cell Science @jcellsci.bsky.social · 17/09/2026
We're now accepting submissions for our next special issue, which will focus on 'Proteostasis' and will be coordinated by two of our Academic Editors, Pedro Carvalho and Tamotsu Yoshimori. Submission deadline: 2 November Find out more: journals.biologists.com/jcs/pages/pr... #proteostasis
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 17/09/2026
This is the future of cognitive surrender.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 09/09/2026
It was so much more interesting to read about Diego Córdoba and Luis Martínez-Zoroa, rather than a stupid machine that spits out numbers. www.quantamagazine.org/ai-has-solve...
quantamagazine.org
AI Has Solved One of Math’s $1 Million Millennium Prize Problems | Quanta Magazine
Mathematicians at OpenAI showed that the Navier-Stokes equations, which describe how fluids flow, can sometimes “blow up.” But the massive result is not without controversy.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 06/09/2026
www.themarginalian.org/2013/12/18/j...
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 02/09/2026
Trying to play Finnish Scrabble with English words but I've run into an issue #helsinki @m1singh.bsky.social
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 02/09/2026
Reading this seriously good book in a seriously spectacular #helsinki #library
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Reposted by Subhojit Roy MD, PhD
Turku BioImaging @turkubioimaging.bsky.social · 26/08/2026
Next Monday, we welcome Prof. Subhojit Roy @roylab-ucsd.bsky.social for a Field of View guest seminar on "Neuronal Trafficking in Physiology and Disease" 🗓️ August 31, 11.00-12.00 EEST 📍Auditorium Biologi, BioCity, Turku Host: Guillaume Jacquemet @guijacquemet.bsky.social Feel free to join!
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 26/08/2026
Looking forward to speaking at this synmposium.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 25/08/2026
"Wheeling freely in the gaps of human knowledge is this India wicketkeeper batter" www.cricinfo.com/story/sl-vs-...
cricinfo.com
The trouble with trying to understand Rishabh Pant and cricket's Three Body Problem
He is quite simply the glitch in cricket's increasingly data-driven matrix: a force of chaos that no algorithm, model or physicist can quite explain
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 24/08/2026
Not bad for a Midwest beer @pjenkinslab.bsky.social !
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 20/08/2026
Didn't realize reason behind the killer bass line in 'I want to Break Free'"
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 19/08/2026
Looking forward to giving a talk next week in Turku, Finland at 35th BioCity Symposium: VISION, EXPANDED (thanks @guijacquemet.bsky.social !): biocityturku.fi/biocity-symp...
biocityturku.fi
BioCity Symposium - BioCityTurku
35th BioCity Symposium: VISION, EXPANDED 27–28 August 2026Mauno Koivisto Centre, BioCity, Turku, Finland Turku is the beating heart of European imaging! The 35th BioCity Symposium “Vision, Expanded” b...
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 18/08/2026
Ok, we know nothing about the brain "More than 80% of eliminated dendritic spines reappeared at their original locations after recovery [from hibernation]": www.science.org/doi/10.1126/...
science.org
Artificial hibernation reveals synaptic engram architecture associated with memory retention
Memories leave lasting physical changes at the synaptic level. Although stable, larger spines are thought to support memory, the high turnover of dendritic spines and the drifting of neuronal represen...
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 18/08/2026
youtu.be/Ip_Qf8rq8jw?...
youtu.be
Mast Mahol Me Jeene de (Fiza, 2000) #anumalik #melodicacover #synth #oberheim #bollywoodsongs
YouTube video by Pandemic Melodica
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 15/08/2026
NIH will now attach Gold, Silver or Black stickers to your grant: grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 14/08/2026
Walked into lab today and talked about funding crisis, climate collapse and the cosmic meaningless of human existence. Wasn't the best idea.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 14/08/2026
I've been wondering how to spot good scientists and found the answer in @themarginalian.org.web.brid.gy 's book TRAVERSAL
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 12/08/2026
"You have not become less capable. You have simply become less novel" - The Second Half of life www.linkedin.com/pulse/what-m...
linkedin.com
What My Tattoo Artist Taught Me About Work After 50
A seven hour tattoo session became an unexpected lesson about work, identity, and life after 50. Yesterday, I spent the first of three seven hour sessions questioning someone who didn’t need to prove ...
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 10/08/2026
now that's a relief: academic.oup.com/rev/article/...
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 10/08/2026
"Every day, we manage veterans whose conditions are profoundly complex, trauma deep, and suffering [that] can turn dangerous. This is not routine primary care; it is a form of service..." @m1singh.bsky.social 's colleague about what VA doc's life has become: www.annfammed.org/content/24/4...
annfammed.org
Maybe I Should Have Taken the Fork
In this reflective essay, a primary care physician describes practicing within the Department of Veterans Affairs during a period of workforce reductions, policy shifts, and changing institutional pri...
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Reposted by Subhojit Roy MD, PhD
Addgene @addgene.bsky.social · 04/08/2026
Twenty years ago, Addgene co-founder Melina Fan, PhD, couldn’t get the plasmids she needed for her research, so she helped build a better way to share them. 🧬 On Aug. 1, Melina stepped into a new role as Chief Scientific Advisor. A thank-you and a look at what’s next:
twp.ai
blog.addgene.org
Thank You, Melina: A New Chapter After 20 Years
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 02/08/2026
"The early video store was often a place to talk as well as to shop, and the persona and expertise of retailers and clerks structured the consumer experience of home video as much as the shelves on the wall" I still have my Blockbuster card. thereader.mitpress.mit.edu/the-lost-civ...
thereader.mitpress.mit.edu
The Lost Civic Life of Movie Rental Stores
Decades before recommendation algorithms, video stores served as social hubs where conversation and camaraderie became a form of taste-making.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 01/08/2026
Key argument why academia is trash...every human "must be a strong business asset" (view shared by the mythical "requiter"):
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 29/07/2026
Every trainee thinks that they can write a paper whenever they want. Some divine intervention will happen as and when necessary, but there is no need to practice anything. Newsflash: You can't just wake up one day and start writing. Just like you can't wake up one day and start playing the cello.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 28/07/2026
"For anyone with an Internet connection and a little discretionary income, the contemporary moment offers a superabundance of seductive distractions" www.theguardian.com/us-news/ng-i...
theguardian.com
Why does everything feel so joyless? Welcome to the age of decadence without pleasure | Michèle Mendelssohn and Charlie Tyson
Decadence in our era comes in technologically mediated forms, emptied of desire and obsessed with self-optimisation
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 13/07/2026
"Jared Cooney Horvath said Gen Z is less cognitively capable than previous generations, despite its unprecedented access to technology...Gen Z is the first generation in modern history to score lower on standardized tests than the previous one" fortune.com/article/how-...
fortune.com
The U.S. spent $30 billion to ditch textbooks for laptops and tablets: The result is the first generation less cognitively capable than their parents | Fortune
Neuroscientist Jared Cooney Horvath said older generations “screwed up” giving students access to so much technology: “I genuinely hope Gen Z quickly figures that out and gets mad.”
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Reposted by Subhojit Roy MD, PhD
Jason Shepherd @jasonsynaptic.bsky.social · 29/06/2026
Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
authors.elsevier.com
Arc mediates intercellular tau transmission via extracellular vesicles
Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 25/06/2026
Interesting to see how few of the "1% papers" say something definitive with a high degree of certainty. Give me something I know is real has become gimme something fuzzy but scintillating that can go in glossy journal. I don't know how to do science anymore.
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Reposted by Subhojit Roy MD, PhD
Christophe 🔬 Leterrier @christlet.bsky.social · 25/06/2026
Souvenir from the Cell Biology of the Neuron GRC in beautiful Tuscany. A great community, looking forward to meet everyone again in two years with @barrlab.bsky.social and @roylab-ucsd.bsky.social at the helm!
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 25/06/2026
Good!
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 23/06/2026
"But doing the minimum required just to keep your advisor or supervisor satisfied probably isn’t the goal. Hopefully, you’re motivated by more than the prospect of avoiding discipline or dismissal" helpimascientist.com/2022/11/20/h...
helpimascientist.com
How hard should science trainees work? One perspective
Help I'm a Scientist - How hard should science trainees work? One perspective by David Fay
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Reposted by Subhojit Roy MD, PhD
MwahahahahahadScientist @mads100tist.bsky.social · 18/06/2026
If you use this, ask yourself: do you really like your job? 🧪
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 14/06/2026
"It's been 84 years but I can still smell the fresh DNA paint...." @christlet.bsky.social reminiscing with @francescabartolini.bsky.social and me at GRC Cell biology of the Neuron, Italy
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Maureen Barr @barrlab.bsky.social · 12/06/2026
A fantastic week at the Cell Biology of the Neuron GRC in Tuscany. @roylab-ucsd.bsky.social & I are organizing 2028, June 4-9: same location A great perk of being a scientist is getting to hang with other scientists. My cup is full. Thank you! @channyskye.bsky.social @rodallab.bsky.social
Maureen & Monica Driscoll exploring Florence the day before the conference. Important for jet lag prevention! In the background is the Arno River, which looks very greenAntonina Roll-Mecak, Maureen, and Avi Rodal in Barca sitting at a green picnic table with red umbrella Maureen and Chantell Evans at the end of conference dinner
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 11/06/2026
GRC Cell Biology of the Neuron Italy. Same venue in 2028 I'm co-chairing with @barrlab.bsky.social
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 09/06/2026
"We lived below the poverty line and my stepfather [abused] my mother and me...Not long after, I escaped from our dingy apartment with a suitcase of essentials and never looked back" From homeless to Ph.D.: How I found my way into research | Science | AAAS share.google/uOXeuM5rJ7GL...
share.google
From homeless to Ph.D.: How I found my way into research
“For much of my scientific training I feared I was behind my peers,” this grad student writes
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 09/06/2026
expect less hair tho...
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 03/06/2026
A perfectly reasonable statement...except Barbara was not purifying tubulin. Crazy story with ups and downs shows how scientific discoveries are really made: onlinelibrary.wiley.com/doi/10.1111/...
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 03/06/2026
yesterday we discussed that for a PI, every experiment takes 6 months or less because stupendous success at every corner is the norm and 18 hour workdays (including weekends) is expected.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 31/05/2026
Would you write a figure legend like this today (John Heuser 1980)? Hey, good thing we are so much more certain of our data than John was in 1980...
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 30/05/2026
"No matter how much we tell ourselves AI is like spell-check, it isn’t. When we use AI to flesh out ideas, we lose the most important part of the writing process: thinking...the effort and the hang-ups are a feature of the human thought process, not a bug" www.theatlantic.com/technology/2...
theatlantic.com
The Biggest Tell That Something Was Written by AI
Look closely and you’ll see that every part of the text is not quite right.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 29/05/2026
Giving a talk? Don't waste time with "practice talks". Stay in slide sorter view & practice 3 things for each slide: 1. What point/s do I want to convey with this slide (</=3). 2. What's the 1-line summary of this slide? 3. What is the transition to the next slide? Something doesn't fit? FIX IT
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 24/05/2026
"Over the last 7 yrs, we published >700 ‘First Person’ interviews...But JCS has been around much longer – in fact, JCS was first established in 1853 as the Quarterly Journal of Microscopical Science (QJMS), re-branded as JCS in 1966" @jcellsci.bsky.social journals.biologists.com/jcs/article/...
journals.biologists.com
‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science
Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.
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Subhojit Roy MD, PhD @roylab-ucsd.bsky.social · 20/05/2026
"Intellia Therapeutics announced that its systemic CRISPR–Cas9 gene editing medicine had met primary and secondary endpoints, leading the biotech to start a rolling submission for US Food and Drug Administration approval" www.nature.com/articles/s41...
nature.com
Intellia heads to FDA with first in vivo CRISPR-based gene editing therapy - Nature Biotechnology
Nature Biotechnology - Intellia heads to FDA with first in vivo CRISPR-based gene editing therapy
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