Mizrak et al. use single-molecule tracking to dissect mechanisms of protein targeting to lipid droplets. They show that nanodomain-based confinement drives selective protein accumulation on lipid drop...

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

Nature Metabolism, Published online: 05 January 2026; doi:10.1038/s42255-025-01427-2Sex profoundly shapes liver metabolism, with oestrogens conferring protection against metabolic liver disease. In this study, Yang, Wang and colleagues identify the orphan G protein-coupled receptor GPR110 as a liver-specific brake on oestrogen signalling, bridging GPCR and nuclear receptor pathways, thus pointing to GPR110 as a target for sex-specific therapy in liver disease.

C-COMPASS is an open-source software designed to predict the spatial cellular distribution of proteins and lipids from cellular organelle profiling using a neural network-based regression model.

Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Prot...

NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, ...

Kevin Hall said his work on ultraprocessed foods has been “hobbled” under the Trump administration. Scientists have been raising such concerns for months.

High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...

In eukaryotic cells, communication between organelles and the coordination of their activities depend on membrane contact sites (MCS). How MCS are regulated under the dynamic cellular environment rema...

US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

No wonder the American public thinks of Democrats as out of touch, opportunistic and cowardly. That is because they are

Words such as “health equity” are being replacing with vaguer terms, and 100 members sent a letter of protest to NASEM leaders.

Nature Cell Biology - It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our ability to study lipids in cells. We asked leaders...

npj Metabolic Health and Disease - Human adipose depots’ diverse functions and dysregulations during cardiometabolic disease