Combination therapy with retatrutide and cagrilintide lowers body weight and improves markers of metabolic health in obese, male rats more efficiently than equimolar monotherapies and matched-dose com...

Appetite suppression by glucagon-like peptide-1 receptor agonists (GLP-1RAs) is thought to result from direct actions on neural circuits controlling food intake. In this article, we (1) propose that a shift in fuel partitioning toward fat oxidation caused by GLP-1RAs contributes to appetite suppression and (2) explore potential lines of research to test this hypothesis.

Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. ...

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

The circadian system regulates daily rhythms in metabolism and hormone secretion; however, in type 2 diabetes, disrupted clock gene oscillations in sk…

YouTube video by CBMR at the University of Copenhagen

YouTube video by CBMR at the University of Copenhagen

Aims/hypothesis Type 2 diabetes has been associated with increased risk of colorectal cancer (CRC), but the specific diabetogenic pathways contributing to this risk remain unclear. Methods We analysed...

Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

From emergency surgeon to discoverer of GLP-1 and its effects on insulin production and satiety, CBMR Group Leader Professor Jens Juul Holst has spent fifty years pursuing one question: how does metab...

Inuit in Greenland possess a unique genome, which has evolved over thousands of years as they adapted to a cold climate and consumed a diet largely consisting of marine mammals. Now, a team of interna...

The evolutionary science of weight regain unpacked.

Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.

AbstractMotivation. The utilization of single-cell bisulfite sequencing (scBS-seq) methods allows for precise analysis of DNA methylation patterns at the i

Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...

The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.

Nature Reviews Endocrinology - Glycogen metabolism: not just a one-trick pony

Researchers from the University of Copenhagen have identified a neural circuit in the mouse’s brain which ensures that it prioritises safety over other needs, e.g. food seeking, and that this happens ...