l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...

Caroline Moosmüller, Alexander Lercher und Gabriele Wadlig wurden für ihre exzellenten Publikationen mit den ASciNA Awards 2025 ausgezeichnet.

My name is Alexander Lercher, and I am currently a Postdoc in the lab of Charlie Rice at Rockefeller University in New York, and I am particularly excited about studying immune responses in the context...

The Rendeiro lab at CeMM is recruiting a highly motivated data scientist to join our international team studying human aging and pathology.

Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and accelerate re-epithelialization while delaying hair regeneration when serine-deprived. These findings suggest new metabolic and pharmacologic strategies to enhance wound repair.

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

Nature - Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.

Join us at the Keystone Symposia on Metabolic and Nutritional Control of Development and Cell Fate, May 2025, in Beverly, with field leaders!