Here, the authors show that changes in the muscle fiber proteome following 8 weeks of resistance training are both sex- and fiber type-specific. This includes greater upregulation of CSRP3 in type II ...

Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV-vector-mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits an...

npj Metabolic Health and Disease - Skeletal muscle proteomics: considerations and opportunities

Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…

Physical activity improves health, yet the molecular mechanisms remain partially understood. This study presents a high-resolution, time-resolved atlas profiling 10,127 proteins across plasma, saliva,...

Muscle samples from over 120 people were analyzed to identify molecular patterns linked to insulin resistance, a key feature of type 2 diabetes. The findings reveal new insights that could help tailor...

Scientists have unearthed surprising details about how our bodies handle insulin – the hormone that plays a crucial role in regulating blood sugar and developing diabetes.

Nicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

Skeletal muscle is a key determinant of sports performance. It is a highly specialized, yet complex and heterogeneous tissue, comprising multiple cell types. Muscle fibers are the main functional cel...

Skeletal muscle is a key determinant of sports performance. It is a highly specialized, yet complex and heterogeneous tissue, comprising multiple cell types. Muscle fibers are the main functional cel....

Exercise regulates the human skeletal muscle interstitial fluid proteome in a distinct temporal manner.