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An interview from the RSB with author Adrian Liston on his new science career book

Placing too much emphasis on a specific interpretation of dimensionality may lead neuroscience down the wrong path.

Animals must balance exploration with threat avoidance, yet how neuromodulatory signals shape information-seeking states remains unclear. Using fibre photometry recordings in the basolateral amygdala ...

A habit develops as a motivated behavior that is strengthened by extended experience and feedback. While the performance component of a habit is relatively well studied, being linked to action-related...

When preparing a scientific paper, we typically write with coauthors who have different backgrounds and styles, and we target readers who have little time and patience. To help both readers and writer...

Growing evidence shows that dopamine signaling is diverse, with dopaminergic neurons responding to rewarding and aversive stimuli. Here, we hypothesiz…

CellTune enables high precision analysis of spatial proteomics datasets through a human-in-the-loop active learning workflow.

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...

Neuropsychopharmacology - Acute fentanyl induces opposing directions of changes in tonic and phasic dopamine release patterns and impairs Pavlovian task performance

In this Analysis, Rupprecht et al. investigate the behavior of GCaMP8 variants in spike inference using several different algorithms. They highlight the role of the indicators’ linearity in the infere...

Cocaine use disorder remains a critical public health concern with limited treatment options. Astrocytes are increasingly recognized as active regulators of neurotransmission and are emerging as impor...

Anxiety disorders, as a critical mental health issue, profoundly impact an individual’s quality of life and social participation while imposing a considerabl...

Neuropsychopharmacology - Dorsal raphe nucleus enkephalin peptide modulates behavioral preference

Disagreement in neuroscience runs deeper than most researchers suspect—even in electrophysiology, a field that prides itself on hard data.

The discovery potentially opens the door to new therapeutic means that could reverse cognitive decline in millions of Alzheimer's sufferers across the globe.

Progress in the use of artificial intelligence (AI) to advance scientific discovery has made it increasingly realistic to envision automated “end-to-end science” (ETES) systems: integrated pipelines t...

Beyond its classical role in gating reward processes, dopamine (DA) also contributes to the orchestration of feeding and energy balance. This review synthesizes and discusses recent advances in unders...

Standard animal learning studies minimize individual reward magnitudes to maximize the repetitions of reinforced behaviors. We investigated how reward magnitude influences initial learning across five...

Brain-wide transcriptomic profiling in mice reveals that reproductive experience remodels the maternal brain by altering dopamine dynamics in the dorsal hippocampal formation, causing dopamine-dependent histone post-translational modifications, and thereby changes in gene expression and behaviour.

This work provides a mechanistic understanding of how certain prefrontal circuits in the rodent brain permit flexibility to selectively stop learned behaviours through interactions with core subcortic...

Grima et al. introduce a novel foraging paradigm to understand how mice can rapidly learn to exploit multi-option environments with varied reward statistics. Decision-making is explained by a model integrating optimal foraging, reinforcement learning, and machine learning. Mesolimbic dopamine best reflects the dynamic global learning rate of the model.

A blood biomarker reveals the mechanistic shift from amyloid to tau pathology

Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implicati...

When writing a grant or reasoning about a problem, AI can exert a subtle, often undetected bias, even when we’re doing our best to be aware of it.

The PyPI package lightning was compromised in versions 2.6.2 and 2.6.3 with Mini Shai-Hulud themed malicious code to execute credential-stealing malware on import.