Early-life exposure to stressors can lead to increased stress susceptibility in later life, shown here to be mediated in mice by SETD7-mediated monomethylation of H3K4 in dopaminergic neurons of the v...

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic priming is necessary and sufficient for early-life stress to sensitize transcriptional, physiological, and behavioral responses to subsequent stressors.

Early-life stress (ELS) sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc) — a key limbic and reward-associated brai...

A new study from researchers at Princeton University and Washington University School of Medicine in St. Louis has uncovered a biological mechanism that may explain why early-life adversity can leave ...

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...