Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

In this study, Luppi et al. systematically characterized and modeled more than 6,000 features of neural activity during anesthesia. They reveal a shared but reversible dynamical endpoint of anesthesia...

Extracting interpretable mathematical models from complex dynamical systems is difficult, especially for chaotic dynamics observed with noisy experimental data. We present PEM-UDE, a method that combi...

Essential cognitive processes like attention, memory, and decision-making require the brain to perform many operations simultaneously. Disentangling the neural mechanisms underlying these processes is...

Scientific Reports - Two distinct excitability types delineate the partition between normal brain function, engram encoding, and the two phases of hyperexcitability/epileptic susceptibility

Your conscious choices may change your brain, and one theory says the work happens in the fatty skin of a single brain cell.

The Massachusetts Institute of Technology pulled ahead on a set of criteria that are as contentious as they are influential.

Resting-state fMRI is routinely described in terms of a small set of recurring whole-brain states. Far less is known about what happens between them. Two pictures compete. In one, the brain toggles : ...

New experiments reveal how astrocytes tune neuronal activity to modulate our mental and emotional states. The results suggest that neuron-only brain models, such as connectomes, leave out a crucial la...

The rapid advances in the capabilities of Large Language Models (LLMs) have galvanised public and scientific debates over whether artificial systems m…

Abstract. Conscious experience depends on the coordinated activity of neural processes that span multiple scales: from synapses to whole-brain dynamics. A recently introduced measure, dynamical indepe...

Europe PMC is an archive of life sciences journal literature.

Di et al. show that two distinct oscillatory neural rhythms encode different aspects of working memory uncertainty. Alpha-band activity carries probabilistic memory representations whose precision pre...

Background Ephaptic coupling is a relatively underexplored mechanism of neuronal interaction mediated by perturbations of the extracellular electric potential without the formation of conventional che...

Neurons share an extracellular medium, so every spike’s current sets up a local field that feeds back onto the membrane potential of nearby cells, an interaction known as ephaptic coupling. The local ...

As A.I. upends education, university leaders have been all over the map about how to respond. It can be very confusing for students.

<p><em>With the release of his first book directly taking on philosophy, </em>On the Equality of All Things<em>, physicist <strong>Carlo Rovelli</strong> takes aim at analytic philosophy's return to r...

Using a combined approach of monkey electrophysiology, artificial neural networks and human psychophysics, Xue et al. show that neuronal interference from irrelevant information underlies behavioral e...

It's like herding sheep, or performing a Mexican wave.

Traveling waves (TWs) are widely observed in the brain and are thought to play multiple functional roles, yet what LFP traveling waves represent remains unclear. Using translaminar recordings in macaq...

Neural activity does not always lie in a low-dimensional subspace. The authors extend this classic view to show that task-relevant information is distributed across multiple covariability classes and ...

The community stagnates without the impulse of the individual. The impulse dies away without the sympathy of the community.” — William James, The Will to

Predictive processing casts perception, action, and learning as probabilistic inference. This paper asks when a Bayesian description identifies a mechanism. I distinguish computational description, al...

The heartbeat and other bodily processes play a surprising role in shaping perception and cognition. https://t.co/vzQegTgSOn

Comparisons are fundamental to science: experiment against model, one organism against another, a system against itself across time. Because many systems, from brains to climate, are characterized by ...

A new theory argues that cognition isn't just wired into the brain — it may be assembled, moment by moment, by traveling electrical waves

Emerging evidence suggests that cortical activity is organized in traveling waves that coordinate neural activity across space and time. How anesthesia alters these waves remains underexplored. We rec...

Selective processing of behaviorally relevant sounds in complex environments requires dynamic modulation of auditory representations. Here, we show that behaviorally relevant sound locations selective...

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If you are well rested and full, your brain tells you that a bruised overripe apple is a piece of subpar fruit to be passed over. However, if you are exhausted and hungry, an overripe apple is categor...

Gary Barnes interviews local, national and international guests skewed towards locally-based issues. He also presents news, and information on the buzz topics of the day through interviews and guests.

Neuroblox provides the first multiscale and mechanistic neural circuit simulation platform built to elicit cognition, mood, and behavior for designing neurotherapeutics.

Gary Barnes interviews local, national and international guests skewed towards locally-based issues. He also presents news, and information on the buzz topics of the day through interviews and guests.

A new study reveals insights into populations of neurons affected by Huntington’s disease, schizophrenia, addiction, and other disorders.

Beyond sustaining life, breathing is a vital physiological rhythm that shapes cognition, perception, emotional regulation, and mental health. Breathing has a direct effect on neuronal excitability and is coupled to neural oscillations across a variety of brain regions. Notably, both respiration and neural oscillations are asymmetric and not perfectly rhythmic: for example, every breath has a different shape and duration, and is interspersed with variable pauses. Here, we examined the coupling between breathing and the brain by quantifying the nonsinusoidal features of each breath and comparing it to the shape of each corresponding neural oscillation cycle. By leveraging invasive human brain recordings from 16 participants (8 female, 8 male), we found respiration-neural waveform coupling on a breath-by-breath, cycle-by-cycle basis across limbic and cortical forebrain regions. For decades, the dominant perspective on cognition and mental health have focused on the brain, but recent work is highlighting the importance of brain-body interactions. Our results show that the coupling between breathing and neural activity is much richer than previously appreciated, and our approach opens new avenues for studying these peripheral-to-central nervous system interactions in a more robust, temporally precise manner. Significance Statement Breathing shapes brain activity, but prior work has characterized this coupling by aggregating across many breath cycles, leaving the fine-grained shape of individual breaths unexamined. Here, we show that the precise waveform shape of each breath is coupled to the shape of corresponding neural oscillation cycles in the human forebrain, on a breath-by-breath basis. Using invasive brain recordings from 16 epilepsy patients, we demonstrate that temporal and amplitude features of individual breaths are linked to the morphology of neural oscillations in limbic and cortical regions. This cycle-by-cycle respiratory-neural coupling reveals a richer and more temporally precise relationship between breathing and brain activity than previously appreciated.