Through a newly identified process called skoupocytosis, neurons recruit the immune cells to remove cellular waste they find hard to deal with themselves.

Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...

Nature Neuroscience - Senne, Suthard and colleagues show that dorsal hippocampal astrocytes display time-compressed calcium-event sequences after foot shock and upon context re-exposure, and that...

Brain imaging across more than 1,200 people identifies two reproducible reward profiles, one tuned to cues and one to outcomes. The two profiles respond in opposite ways to dopamine-blocking drugs, an...

Mice seek information for curiosity’s sake—and their desire for knowledge versus a payout is represented distinctly in the brain, new findings suggest.

Brain activity is complex but not arbitrary, and some patterns dominate others, with dimensionality describing how many such patterns exist. The authors show how brain connectivity controls dimensiona...

The US science-funding agency is withholding $1 billion of its budget so that the money can go to a special White House project.

Interactions between the prefrontal cortex (PFC) and hippocampus (HPC) are crucial for flexible and memory guided behaviour. Because there are no direct projections from PFC to HPC, it is widely presu...

Glutamate cotransmission predicts the behavioral functions and characteristics of dopaminergic neurons in the VTA.

Molecular Psychiatry - Adolescent alcohol exposure disrupts astrocyte-synaptic structural and functional coupling in the male dorsal hippocampus

The programs received about $104 million in federal funds this past year.

GNB1 encephalopathy (GNB1-E) is a rare neurodevelopmental disorder associated with motor dysfunction, epilepsy and learning disability caused by mutations in the gene encoding the G protein subunit Gβ...

Dopamine acts at D2-NMDA receptor heteromers to control glutamatergic transmission and aversive learning.

Amygdala astrocyte primary cilia are disrupted during stress, and their restoration leads to improvements in stress-related behaviour in mice.

Nature Neuroscience - Charbonneau et al. compare how the insula is structured and functions in humans, monkeys and rodents, revealing similarities and differences across species that are likely to...

The lab at our end-of-semester field day

Orthoflaviviruses depend on host metabolic resources to replicate, but how distinct cell types in the central nervous system (CNS) alter their metabolism in response to infection remains incompletely ...

YouTube video by Waterfront Partnership of Baltimore

Varicose projection astrocytes emerge as a conserved reactive phenotype linked to inflammation and brain pathology.

If you’re “actively trying to have babies,” one expert told me, “both the man and the woman should be abstaining” from alcohol.

Chronic opioid use facilitates changes in brain reward and affective systems. Cessation of opioid use induces negative affective states characterized …