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Matt Perich

@mattperich.bsky.social
1.8K followers 192 following 130 posts

Neuroscience, engineering, AI, music. Asst. Professor / PI at University of Montréal and Mila.

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Reposted by Matt Perich
Nanda H Krishna @nandahkrishna.bsky.social · 25/09/2026
MOJO has been accepted to #NeurIPS2026! 🎉 We use SSL + unlabelled data for better decoding, stronger few-shot transfer, and more interpretable embeddings with POYO and POSSM (SoTA decoders for neural spikes). Stay tuned for more results + torch_brain-based code! 👀
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Matt Perich @mattperich.bsky.social · 23/09/2026
Very well deserved! Excited to see what comes next!
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Blake Richards @tyrellturing.bsky.social · 21/09/2026
New benchmark for neuro-foundation models work! Based on the International Brain Laboratory (IBL) this benchmark is ideal for exploring generalization across a variety of domains. If you're doing ML for neural data, you should check it out! #neuroscience #NeuroAI 🧪
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Blake Richards @tyrellturing.bsky.social · 11/09/2026
A new artificial life paper from our Paradigms of Intelligence team, this one led by @kjha02.bsky.social. 🧬 It explores the co-evolution of cooperation and self-replication, with interesting implications for how shared energy budgets can shape these dynamics. 🧪
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Matt Perich @mattperich.bsky.social · 08/09/2026
This was a fun one to write! Check it out if you want my (not-so-spicy) take on the recurring discussions about dimensionality in neural activity.
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Matt Perich @mattperich.bsky.social · 07/08/2026
At long last! I'm excited we can finally share the final published form of CURBD, our method to disentangle multi-regional interactions with RNNs, out today in Neuron. Thanks to @kanakarajanphd.bsky.social and @deisseroth.bsky.social and all of our collaborators! 📃: doi.org/10.1016/j.ne...
doi.org
Redirecting
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Ann Kennedy @antihebbiann.bsky.social · 27/07/2026
Happy Monday! Come learn how jellyfish swim. In a review led by fluid dynamics maestro Alex Hoover, we outline how neuromechanical modeling will help us understand how modulation of neural activity allows jellyfish to jet and pirouette through fluids www.sciencedirect.com/science/arti...
Figure 1. The fluid dynamics of jellyfish swimming. a) Minimum intensity projection of a video clip of swimming Clytia hemisphaerica recorded at 30 fps; dark spots capture trajectories of tentacle bulbs, mouth, and gonads over time. Blue outlines approximate the margin of jellyfish on the frame of maximum extent on two successive swim pulses; green arrow shows direction of swimming. b) Minimum intensity projection of the same animal during a period of turning, showing asymmetry in the movement of bulbs on the inside vs outside of the turn. c) 3D diagram of the bell of a swimming jellyfish, showing starting and stopping vortex rings and fluid flow into (blue) vs away from (purple) the bell during the passive energy recapture phase of swimming. d) Cross section of a swimming jellyfish showing fluid vorticity toward the end of a swim pulse relaxation phase, showing locations of the starting and stopping vortex rings and the boundary layer. e) Swim pulse dynamics of an oblate jellyfish under symmetric bell contraction, producing straight swimming. The starting vortex ring is generated by active muscle contraction of the bell (ii, purple arrows), while the stopping vortex ring is generated by passive elastic relaxation (iii-iv, green arrows) from the mesoglea. Forward motion during the relaxation phase arises from the interaction of the starting and stopping vortex rings, with the starting vortex ring pulling fluid away from the bell and the stopping vortex ring directing fluid into the subumbrellar cavity. f) Swim pulse dynamics under asymmetric bell contraction, producing turning. Initially at rest (i), the neuronal signal initiates a muscular contraction in the bell margin on the inside of the turn before a stronger contraction of the bell margin is observed on the outside of the turn (ii-iii, purple arrows). The corresponding passive restoration yields a stronger expansion of the bell margin on the outside of the turn (iv, green arrows).
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Matt Perich @mattperich.bsky.social · 23/07/2026
New preprint! Joint SSL on neural data improves supervised decoding. Even includes some cool multi-species pretraining results! Great work by @ximengmao.bsky.social @nandahkrishna.bsky.social @averyryoo.bsky.social with @glajoie.bsky.social. Preprint here: arxiv.org/abs/2607.14086, blueprint below!
arxiv.org
Leveraging unlabelled data for generalizable neural population decoding
Robust and accurate neural decoders are integral to neurotechnologies such as brain-computer interfaces and closed-loop experiments. Recent work has shown that tokenizing neural data at the spike leve...
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Reposted by Matt Perich
Jibran Khokhar @drjkhokhar.bsky.social · 26/03/2026
With the rumblings around CIHR wanting to move to one cycle per year not going away, in consultation with a diverse stakeholder group, we have put together a letter for CIHR leadership. Please consider signing this letter and share/RT: docs.google.com/forms/d/e/1F... @cannabrain.bsky.social
docs.google.com
CIHR Project Grant Cycle Restructuring
Dear colleagues, Below you will find a draft letter regarding the proposed transition to a single annual CIHR Project Grant competition, and to invite you to sign on if you are in agreement with its c...
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Bing Wen Brunton @bingbrunton.bsky.social · 24/03/2026
Some of you saw a preview of this result at my Cosyne talk last week. We may have had too much fun working on this worm-fly model 🤣🤓🤣 (The digital sphinx may be imagery, but the lessons are real.)
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Blake Richards @tyrellturing.bsky.social · 19/03/2026
Here's a lovely #blueprint on a new study from our lab led by @royeyono.bsky.social. tl;dr: it implies that there may be interneurons whose role is to normalize credit assignment signals during learning. #neuroscience 🧪
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Matt Perich @mattperich.bsky.social · 17/03/2026
New paper! We introduce JEDI, Jointly Embedded Dynamics Inference for neural dynamics. arxiv.org/abs/2603.10489. JEDI flexibly infers dynamical principles (across behaviors/contexts) from neural population data through RNNs constrained at single-neuron resolution to reproduce that data.
arxiv.org
JEDI: Jointly Embedded Inference of Neural Dynamics
Animal brains flexibly and efficiently achieve many behavioral tasks with a single neural network. A core goal in modern neuroscience is to map the mechanisms of the brain's flexibility onto the dynam...
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Matt Perich @mattperich.bsky.social · 10/03/2026
New paper hot off the (pre-)press! We dig into the evolutionary origins of neural computations for behavioral control across mice, monkeys, and humans: www.biorxiv.org/content/10.6.... As our lab's first foray into comparative analysis of neural dynamics, I’m super excited about this work! 1/18
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Carl T. Bergstrom @carlbergstrom.com · 17/02/2026
1. I’m quite happy with this popular piece that Lee Dugatkin and I wrote recently. For the next two weeks it’s free to read on the American Scientist website.
americanscientist.org
Humbled by Evolution
Understanding the history and diversity of life inspires awe and wonder.
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Tomohiko Takei @tomohikotakei.bsky.social · 12/02/2026
Our paper is out in Science Advances! What makes primate hands so dexterous? We show that evolutionarily distinct spinal and cortical pathways work together to balance stability and flexibility, supporting remarkable primate hand control. www.science.org/doi/10.1126/...
science.org
Primate dexterous hand movements are controlled by functionally distinct premotoneuronal systems
Distinct spinal and cortical pathways coordinate muscle synergies and fine control to support primate dexterous hand movements.
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Matt Perich @mattperich.bsky.social · 11/02/2026
Beautiful to see! Great work!
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Juan Gallego @juangallego.bsky.social · 07/01/2026
🚨📜+🧵🚨 Very excited about this work showing that people with no hand function following a spinal cord injury can control the activity of motor units from those muscles to perform 1D, 2D and 3D tasks, play video games, or navigate a virtual wheelchair By a wonderful team co-mentored w Dario Farina
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Matt Perich @mattperich.bsky.social · 10/12/2025
Go work with Juan! I can vouch that this will be a very cool project.
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Juan Gallego @juangallego.bsky.social · 04/11/2025
🚨Job alert🚨 The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour This is part of a collaborative ARIA grant "4D precision control of cortical dynamics" euraxess.ec.europa.eu/jobs/383909
euraxess.ec.europa.eu
3 Postdoctoral Research Fellows
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.
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Matt Perich @mattperich.bsky.social · 06/11/2025
If you're interested in dynamical systems analysis for neuroscience, definitely check out @oliviercodol.bsky.social 's revised version of our RL paper! Very cool results in the new Fig 6, worth it regardless of if you saw our previous version or if it's all new. www.biorxiv.org/content/10.1...
biorxiv.org
Brain-like neural dynamics for behavioral control develop through reinforcement learning
During development, neural circuits are shaped continuously as we learn to control our bodies. The ultimate goal of this process is to produce neural dynamics that enable the rich repertoire of behavi...
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Matt Perich @mattperich.bsky.social · 07/10/2025
A big "get" for the Champalimaud! Excited to see what comes out of the Warehouse and the next phase of Juan's lab
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eartha mae @endoeartha.bsky.social · 25/09/2025
Very excited and proud to share my postdoctoral research with @neurrriot.bsky.social looking at the context-specific encoding of social behavior 💃🕺 in hormone-sensitive, large-scale brain networks in mice! www.biorxiv.org/content/10.1... #neuroskyence #compneurosky 🧪 1/12
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mchurchland.bsky.social @mchurchland.bsky.social · 08/09/2025
Of potential interest to those keen on motor control and/or multi-task networks. Congrats to Elom and Eric. www.biorxiv.org/content/10.1...
biorxiv.org
Motor cortex flexibly deploys a high-dimensional repertoire of subskills
Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...
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Matt Perich @mattperich.bsky.social · 13/08/2025
🚨 I’m excited to say that my CIHR Project Grant was funded! My NHP lab is now full-speed-ahead, and I’m hiring experimentalists (postdoc, PhD student, and/or a tech/manager). We’ll do multi-region ephys during reaching/grasping in macaques, with behavioral and spinal perturbations.
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Matt Perich @mattperich.bsky.social · 07/08/2025
Awesome work from @juangallego.bsky.social and lab. An interface from single motoneuron control in tetraplegia!
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Kanaka Rajan @kanakarajanphd.bsky.social · 06/08/2025
Check out @jordancollver.bsky.social’s‬ great illustration of modular RNNs training to work like a bio-brain🦾🧠 Thanks to Crearte for featuring our collaboration! www.instagram.com/crearte.ca/p...
instagram.com
The Crearte Foundation | #ArtScience on Instagram: "When a neurobiologist is also a comic artist, science can have a whole new storyline. In a 2022 collaboration between the Rajan Lab at Harvard Med...
6 likes, 0 comments - crearte.ca on July 28, 2025: "When a neurobiologist is also a comic artist, science can have a whole new storyline. In a 2022 collaboration between the Rajan Lab at Harvard Med...
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Juan Gallego @juangallego.bsky.social · 06/08/2025
Very happy about my former mentor Sara Solla having received the Valentin Braitenberg Award for her lifelong contributions to computational neuroscience! Sara will be giving a lecture at the upcoming @bernsteinneuro.bsky.social meeting which you shouldn't miss. bernstein-network.de/en/newsroom/...
bernstein-network.de
Sara A. Solla receives the Valentin Braitenberg Award for Computational Neuroscience 2025 – Bernstein Network Computational Neuroscience
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Matt Perich @mattperich.bsky.social · 04/08/2025
📰 I really enjoyed writing this article with @thetransmitter.bsky.social! In it, I summarize parts of our recent perspective article on neural manifolds (www.nature.com/articles/s41...), with a focus on highlighting just a few cool insights into the brain we've already seen at the population level.
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Juan Gallego @juangallego.bsky.social · 01/08/2025
🚨New paper🚨 Neural manifolds went from a niche-y word to an ubiquitous term in systems neuro thanks to many interesting findings across fields. But like with any emerging term, people use it very differently. Here, we clarify our take on the term, and review key findings & challenges rdcu.be/ex8hW
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Mark Histed @markhisted.org · 30/07/2025
'manifolds', and the overall conception of the brain using a dynamical systems framework, have come a long way.
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Matt Perich @mattperich.bsky.social · 29/07/2025
Check out our new review/perspective (w/ @juangallego.bsky.social & Devika Narain) on neural manifolds in the brain! It was a lot of fun to think through these ideas over the past couple of years, and I'm excited it's finally out in the world! 🔗: www.nature.com/articles/s41... 📄: rdcu.be/ex8hW
nature.com
A neural manifold view of the brain - Nature Neuroscience
Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...
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mayoseanez.bsky.social @mayoseanez.bsky.social · 01/07/2025
Finally out! Eight years after initiating this study with Simon Borgognon, Nicolo Macellari, and Gregoire Courtine, we have uncovered neural population dynamics shared among premotor, motor, and somatosensory cortices during various types of locomotor tasks. www.nature.com/articles/s41...
nature.com
Regional specialization of movement encoding across the primate sensorimotor cortex - Nature Communications
How the cortex generates movement to achieve different tasks remains poorly understood. Here the authors show that the cortex serializes motor control by first performing task-specific computations in...
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Matt Perich @mattperich.bsky.social · 11/06/2025
Our new approach for scalable, generalizable, and efficient neural population decoding is now online! Here we focus on real-time BCI but I'm excited about all of our next steps building on this. Awesome work led by @averyryoo.bsky.social @nandahkrishna.bsky.social @ximengmao.bsky.social
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Avery HW Ryoo @averyryoo.bsky.social · 04/04/2025
Very late, but had a 🔥 time at my first Cosyne presenting my work with @nandahkrishna.bsky.social, Ximeng Mao, @mattperich.bsky.social, and @glajoie.bsky.social on real-time neural decoding with hybrid SSMs. Keep an eye out for a preprint (hopefully) soon 👀 #Cosyne2025 @cosynemeeting.bsky.social
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The Transmitter @thetransmitter.bsky.social · 30/03/2025
Many apparent disagreements over the utility of neural manifolds come from a lack of clarity on what the term really encompasses, argues @mattperich.bsky.social #neuroskyence www.thetransmitter.org/neural-dynam...
thetransmitter.org
Neural manifolds: Latest buzzword or pathway to understand the brain?
When you cut away the misconceptions, neural manifolds present a conceptually appropriate level at which systems neuroscientists can study the brain.
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Martin Seeber @seeber.bsky.social · 10/03/2025
🧠 Our new (NIH funded!) paper reveals how the brain creates internal dynamics during both real- and imagined navigation. We recorded directly from the human hippocampus as participants moved through physical space and when they mentally navigated imagined routes. www.nature.com/articles/s41...
nature.com
Human neural dynamics of real-world and imagined navigation - Nature Human Behaviour
Seeber et al. studied brain recordings from implanted electrodes in freely moving humans. Neural dynamics encoded actual and imagined routes similarly, demonstrating parallels between navigational, im...
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Claudia Clopath Lab @clopathlab.bsky.social · 21/02/2025
Want to hear more about how feedback can guide learning in RNNs for motor adaptation. Here is our new paper in Nat. Com. with Barbara Feulner and @juangallego.bsky.social www.nature.com/articles/s41...
nature.com
A neural implementation model of feedback-based motor learning - Nature Communications
How the brain adapts our movements to new conditions remains unclear. Here, the authors show that a recurrent neural network that controls its output using error-based feedback can learn to count...
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Josh Dudman @dudman.bsky.social · 24/01/2025
Our paper from Junchol Park and collaborators that has been brewing for a while. Trying to capture our thinking about what action specification in striatum means and what would constitute evidence for such a model. Longer thread soon, but it’s online now. www.cell.com/neuron/fullt...
cell.com
Conjoint specification of action by neocortex and striatum
Park et al. show that motor cortex and subcortical striatum act in concert to specify the movement parameters of a reach-to-pull action in mice.
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Matt Perich @mattperich.bsky.social · 18/12/2024
Great initiative! The Transmitter is awesome.
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Blake Richards @tyrellturing.bsky.social · 16/12/2024
1/ Okay, one thing that has been revealed to me from the replies to this is that many people don't know (or refuse to recognize) the following fact: The unts in ANN are actually not a terrible approximation of how real neurons work! A tiny 🧵. 🧠📈 #NeuroAI #MLSky
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Matt Perich @mattperich.bsky.social · 12/12/2024
Well said! Great colleagues make this job fun, and I couldn't imagine a better group of them. Thanks for a great 2024, and looking forward to more science in 2025!
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Amy Orsborn @neuroamyo.bsky.social · 12/11/2024
Fun to see this place coming a bit more alive! I tried my hand at a starter pack for neural engineering & computationally-leaning (systems) neuroscience. Super not exhaustive, so if you want to be added (or removed), just ping me. I'm still working on finding folks here. go.bsky.app/Ty3ftme
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Zach Zeisler @zachzeisler1.bsky.social · 01/11/2024
We have a new paper on bioRxiv today! www.biorxiv.org/content/10.1... Quick thread summary over on Twitter: x.com/ZachZeisler1...
biorxiv.org
Consistent hierarchies of single-neuron timescales in mice, macaques and humans
The intrinsic timescales of single neurons are thought to be hierarchically organized across the cortex. This conclusion, however, is primarily based on analyses of neural responses from macaques. Whe...
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Jonathan A. Michaels @jonathanamichaels.bsky.social · 16/10/2024
How can we train a BCI to produce precise hand movements? Our paper published today in Neuron provides one possibility! We show that the abundant hand posture-related information in the grasping circuit can be used for precise grasp control. www.cell.com/neuron/abstr...
cell.com
Accurate neural control of a hand prosthesis by posture-related activity in the primate grasping circuit
Hand posture is amply represented in the cortex, but brain-computer interfaces (BCIs) have not fully leveraged this signal. Agudelo-Toro et al. developed a method allowing subjects to control a virtua...
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Guillaume Lajoie @glajoie.bsky.social · 16/10/2024
How continuous neural activity learns and support discrete, symbolic & compositional processes remains an important question for cog. sci. and AI. In this preprint we explore ways in which both symbolic and sub-symbolic processing could be achieved using attractor dynamics. arxiv.org/abs/2310.01807
arxiv.org
Discrete, compositional, and symbolic representations through attractor dynamics
Symbolic systems are powerful frameworks for modeling cognitive processes as they encapsulate the rules and relationships fundamental to many aspects of human reasoning and behavior. Central to these ...
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Matt Perich @mattperich.bsky.social · 07/10/2024
Check out our new paper led by @oliviercodol.bsky.social ! We use RNNs to explore possible learning rules that lead to the dynamics we see in brains during behavior. www.biorxiv.org/content/10.1... #neuroskyence #compneurosky #neuroai
biorxiv.org
Brain-like neural dynamics for behavioral control develop through reinforcement learning
During development, neural circuits are shaped continuously as we learn to control our bodies. The ultimate goal of this process is to produce neural dynamics that enable the rich repertoire of behavi...
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Matt Perich @mattperich.bsky.social · 02/10/2024
Who needs more neural manifolds? In my opinion: everyone! This was a fun article to write, thanks to @thetransmitter.bsky.social and @emilytransmitter.bsky.social for making it happen! #neuroskyence #compneurosky #neuroAI
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Aaron Batista @aaronbatista.bsky.social · 14/09/2024
When you fail to perform at your best right when it matters the most, what's going on in your brain? We can now provide an explanation: Exceptionally high stakes interfere with the neural signals of motor preparation. I'd love to hear - what do you think causes it? sciencedirect.com/science/arti...
sciencedirect.com
A neural basis of choking under pressure
Incentives tend to drive improvements in performance. But when incentives get too high, we can “choke under pressure” and underperform right when it m…
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Guillaume Lajoie @glajoie.bsky.social · 13/09/2024
The call for #Cosyne25 workshop proposals is now live! cosyne.org/workshops-call Deadline: October 4th, 2024 please repost!
cosyne.org
Call For Proposals — COSYNE
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Grace Lindsay @neurograce.bsky.social · 13/09/2024
Important info on the state of nonhuman primate research in the US. This is such a core part of neuroscience work. www.jneurosci.org/content/44/3... #neuroskyence
jneurosci.org
The Future of Nonhuman Primate Neuroscience: Peril or Possibilities?
COVID-19 and polio vaccines, HIV/AIDS treatments, blood transfusions, and organ transplantation are just a few of the medical advances made possible by research involving nonhuman primates, specifical...
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