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Neuropsychopharmacology

@npp-journal.bsky.social
1.4K followers 123 following 1.5K posts

Neuropsychopharmacology (NPP) is an official peer-reviewed publication of the American College of Neuropsychopharmacology. We report discoveries and promote training & outreach initiatives.

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Neuropsychopharmacology @npp-journal.bsky.social · 13h
Identification of the galanin-noradrenaline axis as a potential biomarker and therapeutic mechanisms underlying the antidepressant effects of psilocybin
nature.com
CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder
Neuropsychopharmacology - CSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder
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Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
It's time for our final #ThisWeekInNPP of September and we're showing no sign of slowing down as we creep into Spooky Season 🎃👻 Read the latest on nicotine, antipsychotic medications, opioids & relationships between neurodegenerative disorders and psychiatric symptoms 👇 #TWiNPP
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Kira Höffler @kirahoeffler.bsky.social · 22/09/2026
very happy about this one 😊
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Neuropsychopharmacology @npp-journal.bsky.social · 29/09/2026
Noradrenergic signaling regulates hippocampal bioenergetics and contributes to spatial memory
nature.com
Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α
Neuropsychopharmacology - Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α
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Neuropsychopharmacology @npp-journal.bsky.social · 28/09/2026
This nose-poke-restricted vapor cocaine self-administration model in mice provides the opportunity to study inhaled cocaine use and relapse models
nature.com
Development of a nose-poke restricted vaporized cocaine self-administration model in mice
Neuropsychopharmacology - Development of a nose-poke restricted vaporized cocaine self-administration model in mice
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Neuropsychopharmacology @npp-journal.bsky.social · 25/09/2026
New findings show that the GluN2A-selective positive allosteric modulator GNE-5729 improves specific executive functions in a state-dependent manner, advancing our understanding of targeted NMDA receptor modulation
nature.com
Differential and state-dependent effects of the GluN2A-selective positive allosteric modulator GNE-5729 on executive functions
Neuropsychopharmacology - Differential and state-dependent effects of the GluN2A-selective positive allosteric modulator GNE-5729 on executive functions
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Neuropsychopharmacology @npp-journal.bsky.social · 24/09/2026
A sex-specific hippocampal-striatal circuits controls impulsive action
nature.com
A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats
Neuropsychopharmacology - A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats
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Neuropsychopharmacology @npp-journal.bsky.social · 23/09/2026
How does the ADHD-linked receptor latrophilin-3 (ADGRL3) regulate dopamine? Its loss increases dopamine release in brain slices but reduces it in behaving mice, suggesting ADGRL3 may control where dopamine is released rather than simply how much
nature.com
Altered striatal dopamine regulation in Adgrl3 knockout mice
Neuropsychopharmacology - Altered striatal dopamine regulation in Adgrl3 knockout mice
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Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
Welcome back to another 2-page installment of #ThisWeekInNPP 🤩 See below for 11 (‼️) of the newest insights across all spectrums of neuropsychopharmacology research 💊 #TWiNPP
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Anthony Ramnauth @philoneurosci.bsky.social · 22/09/2026
Congratulations @jorge-miranda.bsky.social!! Cool that you're last author!
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Neuropsychopharmacology @npp-journal.bsky.social · 22/09/2026
This study identfied circuit-specific mechanism through which top-down cortical controls supports sustained attention, potentially informing treatments for attentional deficits
nature.com
Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)
Neuropsychopharmacology - Top-down control of sustained attention by medial prefrontal cortex—locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT)
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Neuropsychopharmacology @npp-journal.bsky.social · 21/09/2026
Sex-specific neuroadaptations within dorsal striatal circuits underlie habitual alcohol seeking
nature.com
Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner
Neuropsychopharmacology - Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner
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Neuropsychopharmacology @npp-journal.bsky.social · 18/09/2026
The histone variant splice isoform macroH2A1.1 is a specialized epigenetic regulator of memory consolidation
nature.com
Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation
Neuropsychopharmacology - Splice isoforms of the histone variant macroH2A1 differentially regulate hippocampal gene expression and memory formation
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Neuropsychopharmacology @npp-journal.bsky.social · 17/09/2026
This commentary discussing the importance of systems-level approaches in interpreting kappa opioid receptor function
nature.com
Kappa opioid receptors mediate aversion—and it matters
Neuropsychopharmacology - Kappa opioid receptors mediate aversion—and it matters
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Neuropsychopharmacology @npp-journal.bsky.social · 16/09/2026
This double-blind RCT combines amisulpride administration and cerebral blood flow measurement in both healthy adults and patients with MDD to highlight the ventral striatum as a potential target for anhedonia
nature.com
Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study
Neuropsychopharmacology - Investigating the effect of increased dopamine signaling on cerebral blood flow in Major Depressive Disorder: a double-blind randomized placebo-controlled study
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Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
Recent advances in preclinical and clinical studies support an individual-differences framework of addiction and highlight reward sensitivity as a key driver of vulnerability
nature.com
Recent advances in individual differences in addiction neuroscience in animal models and clinical studies
Neuropsychopharmacology - Recent advances in individual differences in addiction neuroscience in animal models and clinical studies
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Neuropsychopharmacology @npp-journal.bsky.social · 15/09/2026
Fall is here, and there's no better way to celebrate than with this week's edition of #ThisWeekInNPP! 🍁
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Neuropsychopharmacology @npp-journal.bsky.social · 14/09/2026
Selective modulation of orexin receptor sutypes could be a promising therapeutic strategy for stress-related psychiatric disorders
nature.com
Selective orexin receptor cross-over treatment increases resilience and expression of neuroplastic signaling genes
Neuropsychopharmacology - Selective orexin receptor cross-over treatment increases resilience and expression of neuroplastic signaling genes
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Neuropsychopharmacology @npp-journal.bsky.social · 12/09/2026
Congratulations to @acnporg.bsky.social Member @kundakoviclab.bsky.social on delivering an excellent #TEDx talk on Women's Health - and being honored as an Editor's pick 🤩 (I'm sure our own @npp-journal.bsky.social editors would have picked her talk also 😉)
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Negar Fani @negarfani.bsky.social · 01/09/2026
Thank you for featuring our exciting findings, showing how a simple sternal vibration device offers a low effort way to enhance interoception, with effects on white matter plasticity! Alexa Kondas and @timmcdermottphd.bsky.social were the stars here
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Jeremy Hogeveen @jeremyhogeveen.bsky.social · 01/09/2026
We ( @vincentcostaphd.bsky.social and I ) wrote a "Hot Topics" piece for @npp-journal.bsky.social on the potential utility of frontopolar cortex TMS in precision psychiatry. Relevant now that this region has been accessed in some excellent recent NHP studies. www.nature.com/articles/s41...
nature.com
Translating macaque frontopolar cortex discoveries into psychiatric treatments - Neuropsychopharmacology
Neuropsychopharmacology - Translating macaque frontopolar cortex discoveries into psychiatric treatments
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Neuropsychopharmacology @npp-journal.bsky.social · 11/09/2026
This recent study identified altered LC-norepinephrine function as a potential mechanism linking early life adversity to long-lasting cognitive and affective dysfunction
nature.com
Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology
Neuropsychopharmacology - Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology
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Neuropsychopharmacology @npp-journal.bsky.social · 10/09/2026
Meta-analytic evidence supports 5-HT3 receptors as a promising therapeutic target and provides rationale for repurposed 5-HT3 antagonists to address the persistent cognitive and motivational deficits of schizophrenia
nature.com
Serotonin type 3 receptor (5-HT3R) antagonists for negative symptoms and cognitive impairment associated with schizophrenia: a systematic review and meta-analysis
Neuropsychopharmacology - Serotonin type 3 receptor (5-HT3R) antagonists for negative symptoms and cognitive impairment associated with schizophrenia: a systematic review and meta-analysis
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Neuropsychopharmacology @npp-journal.bsky.social · 09/09/2026
This randomized crossover trial in healthy adults suggests that LSD induces sustained behavioral and neural changes that may support learning and psychological flexibility
nature.com
Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study
Neuropsychopharmacology - Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study
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Neuropsychopharmacology @npp-journal.bsky.social · 08/09/2026
This recent study highlights sex-dependent mechanisms of valence processing in the nucleus accumbens medial shell
nature.com
Nucleus accumbens medial shell D1 and D2 medium spiny neurons signal the valence of conditioned stimuli in a sex-dependent manner
Neuropsychopharmacology - Nucleus accumbens medial shell D1 and D2 medium spiny neurons signal the valence of conditioned stimuli in a sex-dependent manner
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Neuropsychopharmacology @npp-journal.bsky.social · 07/09/2026
Phospholipase A2 (PLA2) regulates inhibitory amygdala circuitry and is a potential therapeutic target for trauma-related disorders
nature.com
Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction
Neuropsychopharmacology - Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction
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Neuropsychopharmacology @npp-journal.bsky.social · 04/09/2026
A modified rodent effort-related choice task (mERC) is a sensitive preclinical tool for studying effort-based decision-making and screening potential treatments for motivational dysfunction
nature.com
Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators
Neuropsychopharmacology - Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators
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Neuropsychopharmacology @npp-journal.bsky.social · 04/09/2026
Our latest NPP "Meet the Author" interview features Ty Shannon and Mariam Najeeb, discussing their recent paper, "Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome in mice" 👇
youtube.com
npp's "Meet the Author" Interview with Ty Shannon and Mariam Najeeb
In this episode, we spoke with Ty Shannon and Mariam Najeeb (The Ohio State University) about their recent Neuropsychopharmacology publication, "Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice". You can read the full article here: https://www.natu
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Neuropsychopharmacology @npp-journal.bsky.social · 03/09/2026
Restoration of sleep homeostasis and sleep-dependent plasticity may contribute to ketamine's efficacy in treatment-resistant depression
nature.com
Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression
Neuropsychopharmacology - Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression
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Neuropsychopharmacology @npp-journal.bsky.social · 02/09/2026
CBD shows promise beyond seizure control: Sleep disturbances are highly prevalent in epilepsy & neurodevelopmental disorders. In a mouse model of Angelman syndrome, CBD improved REM sleep, restores daily sleep rhythms, & reduces spontaneous seizures
nature.com
Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice
Neuropsychopharmacology - Cannabidiol corrects sleep deficits and reduces spontaneous seizures in Angelman syndrome model mice
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Neuropsychopharmacology @npp-journal.bsky.social · 02/09/2026
The latest NPP BrainPod episode is here! This episode features Dr. Joshua Gray of the Uniformed Services University, discussing his recent paper, "Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders"
open.spotify.com
Shared genetic architecture and neurobiological pathways of problematic alcohol use and anxiety disorders
NPP BrainPod · Episode
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Neuropsychopharmacology @npp-journal.bsky.social · 01/09/2026
There's no better way to start September than with a rundown of the latest NPP articles 🤩 #TWiNPP Learn more about 🧠 changes after antipsychotic treatment, effects of cannabis on stress relief, DA in pain, somatosensory regulation of food intake & cannabinoid treatments for inflammatory pain 💊
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Neuropsychopharmacology @npp-journal.bsky.social · 01/09/2026
Using longitudinal data from the ABCD Study, white matter microstructure and impulsivity prospectively predicted non-suicidal self-injury in youth, revealing important sex differences in risk pathways
nature.com
White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences
Neuropsychopharmacology - White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences
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ACNP @acnporg.bsky.social · 21/08/2026
Congratulations to Dr. Sarah Sperry a new Associate Member of ACNP! Welcome!! 🌞 Dr. Sarah Sperry
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ACNP @acnporg.bsky.social · 24/08/2026
Congratulations to Dr. Alessandro De Nadai a new Associate Member of ACNP! Welcome!! 👏
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ACNP @acnporg.bsky.social · 25/08/2026
Don’t miss out! ACNP is now accepting applications for new Associate Member, Member, and promotion to Fellow! The deadline: September 24th. Apply today! 📝 Click ➡️ tinyurl.com/2dvvpphp for more information.
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ACNP @acnporg.bsky.social · 26/08/2026
Congratulations to Dr. Jones Parker a new Associate Member of ACNP! Welcome!! 🌞 Jones Parker
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ACNP @acnporg.bsky.social · 28/08/2026
Congratulations to Dr. Lora Cope a new Associate Member of ACNP! Welcome!! 🎉
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ACNP @acnporg.bsky.social · 31/08/2026
Congratulations to Dr. Anita Autry a new Associate Member of ACNP! Welcome!! 🌞 Anita Autry
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Neuropsychopharmacology @npp-journal.bsky.social · 31/08/2026
GABAergic neurons in the ventrolateral periaqueductal gray are key mediators of fentanyl withdrawal-related pain sensitivity and sex-dependent fentanyl intake
nature.com
GABAergic neurons in the ventrolateral periaqueductal gray mediate fentanyl withdrawal and self-administration in mice
Neuropsychopharmacology - GABAergic neurons in the ventrolateral periaqueductal gray mediate fentanyl withdrawal and self-administration in mice
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Neuropsychopharmacology @npp-journal.bsky.social · 28/08/2026
he submedius thalamus and orbitofrontal cortex mediate a bidirectional circuit that underlies the time-dependent intensification of oxycodone craving during abstinence
nature.com
Role of submedius thalamus and its interaction with orbitofrontal cortex in incubation of oxycodone craving
Neuropsychopharmacology - Role of submedius thalamus and its interaction with orbitofrontal cortex in incubation of oxycodone craving
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Neuropsychopharmacology @npp-journal.bsky.social · 27/08/2026
Adolescent cannabis use tracked with lower subcortical tissue iron in dopamine-rich regions (VTA, pallidum, thalamus), an MRI proxy for dopamine neurophysiology. Cannabis concentrates showed stronger links than flower.
nature.com
The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use
Neuropsychopharmacology - The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use
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Neuropsychopharmacology @npp-journal.bsky.social · 26/08/2026
In a rat model, offspring of dams given uncontrolled gestational oxycodone showed more drug taking and seeking than offspring of self-administering dams, despite similar exposure. Effects were strongest in female offspring
nature.com
Examining the impact of maternal oxycodone self-administration during gestation in a translational model
Neuropsychopharmacology - Examining the impact of maternal oxycodone self-administration during gestation in a translational model
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Neuropsychopharmacology @npp-journal.bsky.social · 25/08/2026
Our last #ThisWeekInNPP of August is here, and it's a 2-pager packed with the latest and greatest findings in neuropsychopharmacology, so don't miss out! 👇 #TWiNPP
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Neuropsychopharmacology @npp-journal.bsky.social · 25/08/2026
Knockdown of enkephalin in the dorsal raphe nucleus raised pain sensitivity and odor aversion while lowering sucrose preference and social interaction — identifying a non-serotonergic population that promotes reward.
nature.com
Dorsal raphe nucleus enkephalin peptide modulates behavioral preference
Neuropsychopharmacology - Dorsal raphe nucleus enkephalin peptide modulates behavioral preference
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Neuropsychopharmacology @npp-journal.bsky.social · 24/08/2026
Alcohol-related shifts in acetate metabolism appear reversible. Heavy alcohol drinkers showed elevated brain acetate oxidation, which dropped after ~1 week of abstinence but normalized to light-drinker levels by 1 month.
nature.com
Reversible alterations of brain acetate metabolism associated with alcohol consumption
Neuropsychopharmacology - Reversible alterations of brain acetate metabolism associated with alcohol consumption
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Neuropsychopharmacology @npp-journal.bsky.social · 21/08/2026
In this recent study, rapid computational markers of decision-making predicted daily smoking and cessation outcomes. Higher craving and depressive symptoms forecasted more smoking, while first-week data alone predicted treatment success.
nature.com
Rapid and reliable computational markers of decision-making for predicting daily smoking behavior and smoking cessation treatment outcomes
Neuropsychopharmacology - Rapid and reliable computational markers of decision-making for predicting daily smoking behavior and smoking cessation treatment outcomes
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Neuropsychopharmacology @npp-journal.bsky.social · 20/08/2026
Dysregulated allele-specific gene expression may help link genetic risk to structural brain abnormalities across multiple major psychiatric illnesses
nature.com
Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders
Neuropsychopharmacology - Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders
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ACNP @acnporg.bsky.social · 06/08/2026
Please join us in Congratulating the 2026 ACNP Travel Award Class! 👏🤩 Click Here ➡️ tinyurl.com/5bzaz8va for more information on Travel Awards. 📝
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ACNP @acnporg.bsky.social · 10/08/2026
ACNP is now accepting applications for new Associate Member, Member, and promotion to Fellow! The deadline: September 24th. Apply today! 🎉 Click ➡️ tinyurl.com/2dvvpphp for more information.
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