Combination therapy with retatrutide and cagrilintide lowers body weight and improves markers of metabolic health in obese, male rats more efficiently than equimolar monotherapies and matched-dose combinations incorporating semaglutide or tirzepatide.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the h...

Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implicati...

Warden et al. analyze 574 NIH-funded publications (2017–2024) to assess implementation of the Sex as a Biological Variable policy. They find that most studies include both sexes, but fewer than half a...

Abstract. Polycystic ovary syndrome (PCOS) is a common reproductive disorder characterized by irregular ovulation, cyst-like follicles on the ovaries, and

The incidence of Alzheimer's disease (AD) is increasing globally but there are limited effective therapies available. Recently, evidence has demonstra…

Are you a young journalist writing about science and technology? Do you have questions about the impact of Artificial Intelligence (AI) on newsrooms,

Abstract. While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeu

From 24 -26 June 2025, young journalists from across Europe came together at the European Parliament in Brussels for the European Science-Media Hub (ESMH)

Do you want to contribute to improving human health? Join a dynamic and inclusive research group at the forefront of psychoneuroimmunology, where we investigate the interplay between behavior, brain f

The authors describe a sensory circuit involving the medial septum (MS), where MS glutamatergic neurons integrate food odours to prime satiety and regulate nutrient intake.

Abstract. Some evidence suggests that ghrelin in plasma undergoes proteolytic processing, leading to the generation of shorter peptides containing the bioa

This questionnaire will take approximately 15- 25 minutes to complete. Please answer in a safe environment and as truthfully as possible. As a neurodiverse research team, we prioritize the comfort an...

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

Wang et al. identified that the mechanoreceptor PIEZO2 is abundantly expressed in fat-innervating sensory neurons and plays a crucial role in mediating the adipose afferent pathway.

Molecular biology; Neuroscience

High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...

Gut-produced glucagon-like peptide-1 (GLP-1) and pancreas-made amylin robustly reduce food intake by directly or indirectly affecting brain activity. …

Abstract. Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, af

Abstract. While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeu

ALT: a bald man says quite frankly i 'm overwhelmed in a video

Abstract. While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeu

Yang et al. identify and characterize distinct sugar- and fat-responsive neuronal populations in the dorsal hippocampus and their contribution to the development of obesity.

Abstract. While obesity and diabetes are prevalent in both men and women, some aspects of these diseases differ by sex. A new blockbuster class of therapeu

When food is freely available, eating occurs without energy deficit. While agouti-related peptide (AgRP) neurons are likely involved, their activation…

The growth hormone secretagogue receptor (GHSR) and the cannabinoid receptor type 1 (CB1R) are G-protein coupled receptors highly expressed in the brain and involved in critical regulatory processes, ...

Lipid nanocarriers can be used to modulate release of multiple endogenous hormones from the enteroendocrine system.

A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric d...

Obesity is a chronic disease that contributes to the development of insulin resistance, type 2 diabetes (T2D), and cardiovascular risk. Glucose-depend…

Orthogonal murine models demonstrate the bioactivity and neuronal targets of a GLP-1/leptin coagonist in relation to food intake and body weight.

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