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Mark D Humphries

@markdhumphries.bsky.social
3.9K followers 288 following 121 posts

Theoretical systems neuroscientist. Author of “The Spike: An Epic Journey Through the Brain in 2.1 Seconds”: tinyurl.com/ymwy9jrh Lab: humphries-lab.org Essays on the brain: drmdhumphries.medium.com

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Mark D Humphries @markdhumphries.bsky.social · 24/09/2026
Crimes against dopamine number 14,689: “Dopamine sites” www.bbc.co.uk/news/article...
bbc.co.uk
Dopamine sites: India and the world are discovering the thrill of shopping without buying
Dopamine sites mimic shopping’s thrill without the spending, turning the ritual of consumption into a digital game.
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Amirreza Bahramani @amir137.bsky.social · 31/08/2026
Four months ago, US sanctions shut Iranian students out of Neuromatch. So we built our own! 180+ students, 9 TAs, 14 mentors, and an incredible team made NeuroCONNECT happen. Proud to have been part of it. A reminder that sometimes, together, we can break the barriers and injustices imposed on us.
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Carolina Rezaval @crezaval.bsky.social · 16/09/2026
We’re hiring two postdocs! Join our Lab @unibirmingham.bsky.social to uncover how the brain resolves behavioural conflicts. Deadline: 22 September 2026 @wellcometrust.bsky.social Please share! www.rezavallab.org
rezavallab.org
Home
​ ​Animals must make crucial behavioural choices on a minute by minute basis to survive in a changing environment. A long-standing enigma is, how are alternative options evaluated in the brain...
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David Robbe @davidrobbe.bsky.social · 02/07/2026
Excited to share our new paper: "The Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving mice,". Out now in @cp-iscience.bsky.social 🧵1/9 www.cell.com/iscience/ful...
cell.com
The Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving mice
Biological sciences; Behavioral neuroscience; Laboratory animal science
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Mark D Humphries @markdhumphries.bsky.social · 08/09/2026
Terrific piece from @mattperich.bsky.social on how to think about the dimensionality of neural activity Will be borrowing the excellent folding paper analogy… www.thetransmitter.org/neural-dynam...
thetransmitter.org
Dimensionality—neuroscience’s red herring?
Placing too much emphasis on a specific interpretation of dimensionality may lead neuroscience down the wrong path.
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The Transmitter @thetransmitter.bsky.social · 25/08/2026
The Transmitter's summer reading list highlights upcoming neuroscience books and other notable titles from this year—with books by @romainbrette.bsky.social, @susanacarmona.bsky.social, @markdhumphries.bsky.social, David Susillo and more. #neuroskyence By @franciscorr25.bsky.social bit.ly/4qz0oXj
thetransmitter.org
The Transmitter’s reading list for 2026
Our summer reading list includes books on the Human Brain Project, the neuroscience of motherhood and the career of a Huntington’s disease researcher.
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Mark D Humphries @markdhumphries.bsky.social · 21/07/2026
New preprint from Jasper Teutsch & Rohan Rao in Abhi Banerjee's lab showing that switching from choice- to cue-driven behavioural strategies is driven by lOFC In collaboration with Silvia Maggi & I, using our Bayesian strategy analysis doi.org/10.7554/eLif... doi.org/10.64898/202...
doi.org
Distinct Orbitofrontal Feedback Signals Shape Sensory Behavioral Strategies during Flexible Learning
Animals adapt their behavior by integrating sensory evidence with prior experience and contextual information. Understanding how animals employ specific behavioral strategies to integrate these variab...
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Mark D Humphries @markdhumphries.bsky.social · 17/07/2026
Help needed! I'm part of a team tasked with creating a 2nd year undergraduate module/course "Computational Skills for Psychologists" Its remit is the fundamentals of coding and good practice. Any advice from others who've done similar courses? (Assume no programming knowledge. Assume Python)
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Mark D Humphries @markdhumphries.bsky.social · 17/07/2026
Help needed! I'm part of a team tasked with creating a 2nd year undergraduate module/course "Computational Skills for Psychologists" Its remit is the fundamentals of coding and good practice. Any advice from others who've done similar courses? (Assume no programming knowledge. Assume Python)
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Mark D Humphries @markdhumphries.bsky.social · 09/07/2026
More nuanced take on the impending end of artisanal neuroscience thanks to the AI Industrial Revolution Thoughtful piece from Kenneth Harris One question - who are the Luddites in this analogy? www.thetransmitter.org/artificial-i...
thetransmitter.org
Mass-produced science is coming. What happens to scientists?
Artificial intelligence may soon enable researchers to generate high-quality science at a previously unimaginable speed.
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Kenji Lee @kenjilee.bsky.social · 01/07/2026
Adding to all the takes on this, something that is missed and why I don't think AI will progress beyond research assistant in neuroscience is so much of the work is embodied. Not just in that "an LLM doesn't have a body" but so much of the knowledge is only gained through embodiment.
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Mark D Humphries @markdhumphries.bsky.social · 01/07/2026
At Cosyne, Chris Olah from Anthropic told us that neuroscientists had “3-4 years left to make a contribution” Why was not clear. Perhaps he was hinting at the below graph accompanying today’s Claude Science launch. Apparently we’ll all be obsolete soon.
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Mark D Humphries @markdhumphries.bsky.social · 10/06/2026
The Group for Neural Theory is an enviable place to work. At the heart of Paris’s Left Bank, it’s a literal stone’s throw from the Pantheon And it has a remarkable training record On the occasion of its 20th birthday celebrations this week, here’s a further sample of its alumni… gnt20.github.io
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Joao Barbosa @jbarbosa.org · 10/06/2026
So hyped for this! What a privilege to have spent 4 years in this little corner of Paris. GNT has had such a profound impact on the computational neuroscience community. Paris is one of the best places in the world to do neuroscience and the GNT has been fundamental to that Here's to 20 more years🍻
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Mark D Humphries @markdhumphries.bsky.social · 10/06/2026
The Group for Neural Theory is an enviable place to work. At the heart of Paris’s Left Bank, it’s a literal stone’s throw from the Pantheon And it has a remarkable training record On the occasion of its 20th birthday celebrations this week, here’s a further sample of its alumni… gnt20.github.io
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Mark D Humphries @markdhumphries.bsky.social · 08/06/2026
The Group for Neural Theory is celebrating its 20th birthday this week with a party in Paris! gnt20.github.io One thing we’re celebrating is its remarkable training record A thread…
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Mark D Humphries @markdhumphries.bsky.social · 08/06/2026
The Group for Neural Theory is celebrating its 20th birthday this week with a party in Paris! gnt20.github.io One thing we’re celebrating is its remarkable training record A thread…
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Mark D Humphries @markdhumphries.bsky.social · 06/06/2026
A few years ago a pioneering study showed 70 teams of neuroimagers analysing the same dataset couldn’t agree on answers to the same basic questions (my take on that study is below) Now another brave team are aiming to do the same test for systems neuroscience… medium.com/the-spike/se...
medium.com
Seventy Teams of Scientists Analysed the Same Brain Data, and It Went Badly
What the latest fMRI “crisis” means for the rest of science
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Andreas Horn @andreashorn.org · 30/05/2026
Tremor is highly heterogeneous, leading to a familiar clinical puzzle: with deep brain stimulation (DBS), we can sometimes suppress a patient's rest tremor almost completely, while action tremor remains bothersome. www.cell.com/cell-reports...
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Liana Akobian @lakobian.bsky.social · 19/05/2026
I had a peek at the workshop program today and it's PACKED with amazing talks
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Mark D Humphries @markdhumphries.bsky.social · 16/05/2026
The Group for Neural Theory in Paris turns 20 this year Come help us celebrate! June 11-12 at ENS, Paris. Keynotes: @jpillowtime.bsky.social / Cristina Savin /Ashok Litwin-Kumar Talks from GNT alumni Register for free, by May 20th www.eventbrite.com/e/gnt-turns-...
eventbrite.com
GNT TURNS 20!
This workshop will celebrate 20 years of neural theory!
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Mark D Humphries @markdhumphries.bsky.social · 18/05/2026
OK, what am I missing? Claims neurons are ~ a logistic function because inputs sum additively But analysis uses as “inputs” any other neuron in the same recording So appears to be rediscovering that neurons are linearly correlated And that’s it? www.nature.com/articles/s41...
nature.com
Simple input–output dependencies explain neuronal activity - Nature Physics
In neurons, the mapping from inputs to output involves complex biophysical processes. Despite this complexity, it is now shown that simple artificial models explain a large fraction of the variability...
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Mark D Humphries @markdhumphries.bsky.social · 16/05/2026
The Group for Neural Theory in Paris turns 20 this year Come help us celebrate! June 11-12 at ENS, Paris. Keynotes: @jpillowtime.bsky.social / Cristina Savin /Ashok Litwin-Kumar Talks from GNT alumni Register for free, by May 20th www.eventbrite.com/e/gnt-turns-...
eventbrite.com
GNT TURNS 20!
This workshop will celebrate 20 years of neural theory!
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Mark D Humphries @markdhumphries.bsky.social · 07/05/2026
It’s done! Just submitted the manuscript for my next book “The Latent Brain” In it I argue why and how we’ve shifted from single neurons to their collective, latent activity in our quest to understand how brains create minds Due early 2027 from @harvardpress.bsky.social
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Laura Grima @lauragrima.bsky.social · 09/05/2026
Really pleased that this work with @dudman.bsky.social is now out in Neuron: A global dopaminergic learning rate enables adaptive foraging across many options
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Mark D Humphries @markdhumphries.bsky.social · 07/05/2026
It’s done! Just submitted the manuscript for my next book “The Latent Brain” In it I argue why and how we’ve shifted from single neurons to their collective, latent activity in our quest to understand how brains create minds Due early 2027 from @harvardpress.bsky.social
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Prof Jenny Rohn @jennyrohn.bsky.social · 26/04/2026
“Conferences were much more exciting as a young, early-career researcher, when every contact felt like an instant friend and every new city, a gift” My most recent blog post on the effect of age on travel perceptions occamstypewriter.org/mindthegap/2...
occamstypewriter.org
In which I come home | Mind the Gap
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The Transmitter @thetransmitter.bsky.social · 14/04/2026
Ahead of @thetransmitter.bsky.social's first-ever University Roadshow in the United Kingdom, here’s a roundup of news and perspectives featuring U.K.-based neuroscientists. #neuroskyence
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Lukas A. Basedow, PhD @labasedow.bsky.social · 29/03/2026
Highly recommend this series by @markdhumphries.bsky.social if you are interested in neuroscience. I have been irregularly reading it for about 5 years. Always great! medium.com/the-spike/20...
medium.com
2025: A Review of the Year in Neuroscience
Enlightening the brain
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Mark D Humphries @markdhumphries.bsky.social · 26/03/2026
Job! My lab is hiring a pre-doctoral research assistant to work on the neural computations of foraging, seeking common cross-species algorithms. In collaboration with @brainapps.bsky.social & Nathan Lepora. Closes April 21st Pls share! jobs.nottingham.ac.uk/vacancy.aspx...
jobs.nottingham.ac.uk
Job Vacancy at the University of Nottingham: Research Assistant (Fixed-term)
We seek a predoctoral research assistant to join the Humphries’ group at the University of Nottingham on a BBSRC-funded project to study the neural basis of foraging, in collaboration with the groups of Matthew Apps (Birmingham) and Nathan...
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Marcus Ghosh @marcusghosh.bsky.social · 26/02/2026
How can we build better experiment-theory collaborations in neuroscience? We're hosting a series of 6 in-person, interactive workshops to discuss this. Come along! www.eventbrite.co.uk/e/understand...
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Mark D Humphries @markdhumphries.bsky.social · 14/03/2026
#Cosyne2026 How does motor cortex control discrete and rhythmic movements of the arm - the same or different? Find out at our poster 3-014 this afternoon! Work led by @andreacolins.bsky.social
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Adrien Peyrache @apeyrache.bsky.social · 11/02/2026
New paper alert! 🚨 We found that the brain's compass is remarkably stable at two scales 1️⃣ the system maintains its internal organization for weeks 2️⃣ It "remembers" its orientation for weeks, even after a single visit This may be key to how the brain aligns its other maps. Paper: rdcu.be/e3waP
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Philip Ball @philipcball.bsky.social · 14/02/2026
Just added this to my WordPress site, so it's free to read. homunculusmusic.wordpress.com/2026/02/14/e...
homunculusmusic.wordpress.com
Epstein’s ugly world of science
As with Peter Mandelson, so in the science world: the Epstein files are not telling us anything that most ordinary punters didn’t already know, but are revealing the full, rotten, appalling extent …
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Steve Ryan @stevejohnryan.bsky.social · 09/01/2026
I missed some exciting stuff last year!
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Anastasia Christakou 💙 @christakou.bsky.social · 07/01/2026
I can't believe it took me this long to find @markdhumphries.bsky.social on Bluesky, but his annual review makes up for the lost time. On excellent form as always.
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Andrew Pruszynski @andpru.bsky.social · 01/01/2026
Great read as always. There is clearly accelerating tension between ever more complex computational approaches applied to brain data and actually figuring stuff out about the brain.
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Mark D Humphries @markdhumphries.bsky.social · 30/12/2025
Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...
medium.com
2025: A Review of the Year in Neuroscience
Enlightening the brain
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Nicole Rust @nicolecrust.bsky.social · 30/12/2025
Always full of insightful laughs! Thank you for keeping it up for 10 years, @markdhumphries.bsky.social. " ... It can though predict with fair accuracy the activity of held-out neurons during videos of natural scenes. Scenes like driving through a desert. As mice do ... "
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David Klindt @david-klindt.bsky.social · 30/12/2025
Great summary, thanks for writing this! One nit, we started the 'core' merely as a shared feature space for (translation invariant) visual neurons*. Simple idea, not to be conflated with all the 'foundation model' and 'digital twin' marketing later 😜 * proceedings.neurips.cc/paper/2017/f...
proceedings.neurips.cc
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Mark D Humphries @markdhumphries.bsky.social · 30/12/2025
Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...
medium.com
2025: A Review of the Year in Neuroscience
Enlightening the brain
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Mark D Humphries @markdhumphries.bsky.social · 09/12/2025
🚨Funded PhD studentship project🚨 "Leveraging population activity trajectories to optimise Brain-computer interfaces for arm movement" with myself & @katjakornysheva.bsky.social By: Jan 9th 2026 Info on project, funding & how to apply:  more.bham.ac.uk/mrc-aim/phd-... (submit to Nottingham)
more.bham.ac.uk
PhD Opportunities – MRC AIM
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Michael Lin, MD PhD @michaelzlin.bsky.social · 06/12/2025
Read yet another review today that ascribes GECIs' larger SNR vs GEVIs to their being evolved earlier (suggesting the GECIs are better optimized). This assumption is understandable but incorrect. GEVIs' photonic response per molecule per AP have been as good as GECIs since ASAP3.
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Mark D Humphries @markdhumphries.bsky.social · 27/11/2025
Terrific work led by @emmaroscow.bsky.social showing that hippocampal replay reflects events with large prediction errors, all the better to bootstrap learning as we slumber Congratulations to Matt Jones & Nathan Lepora for seeing this through to the end! www.nature.com/articles/s41...
nature.com
Post-learning replay of hippocampal-striatal activity is biased by reward-prediction signals - Nature Communications
It is unclear which aspects of experience shape sleep’s contributions to learning. Here, by combining neural recordings in rats with reinforcement learning, the authors show that reward-prediction sig...
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Mark D Humphries @markdhumphries.bsky.social · 12/11/2025
🧪Preprint! How foragers depart from optimal models can tell us a lot about how they compute their decisions. A strong but underexplored departure is that foragers widely vary when they leave identical patches. A 🧵 doi.org/10.1101/2025... With @emmavscholey.bsky.social @brainapps.bsky.social
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Emma Scholey @emmavscholey.bsky.social · 13/11/2025
Excited to share our preprint on variability in patch leaving decisions! Check out the 🧵 below
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Matthew Apps @brainapps.bsky.social · 12/11/2025
Super pleased with this one, led by the amazing PhD student and foraging expert @emmavscholey.bsky.social!
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Mark D Humphries @markdhumphries.bsky.social · 12/11/2025
🧪Preprint! How foragers depart from optimal models can tell us a lot about how they compute their decisions. A strong but underexplored departure is that foragers widely vary when they leave identical patches. A 🧵 doi.org/10.1101/2025... With @emmavscholey.bsky.social @brainapps.bsky.social
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Riccardo Storchi @rstorchi.bsky.social · 09/11/2025
Delighted to share our latest preprint. It's been a long time coming. Thanks to all the authors for their unique contribution and for for their patience. We show how the visual thalamus deals with active and passive head motion in freely moving animals: www.biorxiv.org/content/10.1...
biorxiv.org
Efficient mixed representation of active and passive motion in the mouse visual thalamus during natural behaviour
During natural behaviour, changes in the visual scene are largely driven by the subject’s own movements, which can be actively generated (e.g., walking) or passively imposed by external forces (e.g., ...
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Nathaniel Comfort @nccomfort.bsky.social · 08/11/2025
Okay, here are some first reflections on Watson. Watson's life is a tragedy, really of Shakespearean proportions. He did not, as most bios will tell you, do one great thing when he was young and then collect laurels for it for the next 60 years. His career arc was unlike any in science.
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