An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

Intelligent behavior requires experience-dependent internal representations of relevant information. We examined representational learning in telencephalic area pDp of adult zebrafish, the homolog of ...

Animals must balance exploration with threat avoidance, yet how neuromodulatory signals shape information-seeking states remains unclear. Using fibre photometry recordings in the basolateral amygdala ...

Detailed behavior analysis is essential for thorough characterization of ethologically relevant behaviors in model organisms, yet manual annotation of the full behavioral repertoire remains subjective...

Rapid learning, memory, and generalization are often attributed to circuits of the neocortex and hippocampus, but their specific role remains unclear. To examine these cognitive abilities together in ...

Tracking your position in the environment during navigation requires integrating multiple signals into a spatial representation. This process is thought to occur primarily in the hippocampal formation...

Whole-brain activity mapping, targeted cell manipulations and electrophysiology in mice identify wake-activated neuronal populations that are crucial for sleep drive and can persistently red...

When preparing a scientific paper, we typically write with coauthors who have different backgrounds and styles, and we target readers who have little time and patience. To help both readers and writer...

Neurons have long taken top billing in memory, but researchers are making the case for astrocytes.

Using in vivo whole-cell recordings during goal-directed navigation, Bhatia, Adel, and Grienberger identify plateaus as a prominent feature of subiculum activity. These events preferentially occur nea...

Cortical computations emerge from the coordinated activity of recurrent neural circuits and are often described through population dynamics and neuronal selectivity. However, how the backbone of the c...

The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...

LATeNT is a light-activatable form of tetanus neurotoxin that can be used for spatiotemporally precise inhibition of exocytosis in neurons and other cells. It can inhibit synaptic transmission in vivo...

What is a natural behavior? I argue that the study of natural behaviors is often the study of the spontaneous behaviors of animals placed in quantifiably different environments. For behavioral general...

Forgotten memories in Drosophila persist as silent memory traces and can be recovered by reminder cues. Manipulating reminders can create false memories, showing that memory reconstruction flexibly in...

A forgotten memory is not always a vanished one. FMI neuroscientists investigating the fruit fly brain found that some memories become inaccessible while leaving a silent trace behind. The right remin...

Cortical pyramidal neurons project a long apical dendrite to layer 1 (L1), to receive synaptic inputs that are thought to provide contextual and possibly suppressive modulation. In visual cortex, thes...

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

Theo Murphy meeting organised by Professor Matthew Grubb, Professor Maren Engelhardt and Professor Maarten H P Kole

Thalamocortical projections shape the functional regionalization and parallel sensory computations across the mammalian cortex. However, the principles of thalamocortical computations in non-mammalian...