Sign in

Micha Sam Brickman Raredon

@msbr89.bsky.social
1.3K followers 1.9K following 248 posts

Scientist/Engineer. Assistant Professor @ Yale School of Medicine. Tissue Biology, Lung Regeneration, Data Science. Here to learn! RaredonLab.com & GitHub.com/RaredonLab

PostsRepliesMedia
Reposted by Micha Sam Brickman Raredon
Epigenome Technologies @epigenometech.bsky.social · 5h
Epigenetics News - Old hearts age backwards: transplanted organs adjust to host's biological age www.nature.com/articles/d41... #Epigenetics #News #Aging #Transplant --- Cancer, immunology, and aging; epigenometech.com
nature.com
Old hearts age backwards: transplanted organs adjust to host’s biological age
Tracking the biological age of grafted organs suggests that donor pools could be expanded to boost organ availability.
044
Reposted by Micha Sam Brickman Raredon
Schallek Lab @schalleklab.bsky.social · 5h
#FluorescenceFriday Pericytes are tiny cells that surround microvessels. Here we show how single cells wrap their "tentacles" around retinal capillaries 👁️ Color: renders depth bit.ly/3TFifQe @flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social @urochester.bsky.social
1164
Reposted by Micha Sam Brickman Raredon
Berna Devezer @devezer.bsky.social · 14h
A revised version of this preprint is now posted on arXiv. The theory section is rewritten, improving model exposition based on feedback we received, we fixed some confusion and errors, contextualized the models more carefully so the interpretation becomes clearer, and improved the overall writing.
arxiv.org
The Difference Between "Replicable" and "Not Replicable" Is Not Itself Scientifically Replicable
Replication studies estimate the replicability rate of scientific results by aggregating binary verdicts of experiments as ``replicated'' and ``not replicated''. These estimates assume rarely attainab...
46617
Reposted by Micha Sam Brickman Raredon
Arjuna Rajakumar PhD @arjunarajakumar.bsky.social · 19/09/2026
So proud of my lab mate @sagrill.bsky.social (whose on the job market 👀) for this magnum opus from @remlehmann.bsky.social lab @whiteheadinstitute.bsky.social ScRNA-seq of 🪰 germ cells reveals new biology, answers age old questions, and proposes new paradigms! 1/8 www.biorxiv.org/content/10.6...
Drosophila stage 10b embryo w/HCR staining marking two germ cell clusters. One will successfully colonize the gonad and the other, like tears in the rain, will be lost forever
35928
Reposted by Micha Sam Brickman Raredon
Paul Byrne @theplanetaryguy.com · 15h
This will never stop blowing my mind. A 12-year sequence of real telescope images of a star 133 lightyears away. And around it, four planets slowly orbiting. Four real exoplanets, each more massive than Jupiter, imaged as they move around their host star.
241717479
Reposted by Micha Sam Brickman Raredon
dalemoulding.bsky.social @dalemoulding.bsky.social · 01/10/2026
Having seen the news: www.bbc.co.uk/news/article... thought I'd share a cilia movie captured at UCL GOS ICH with Eriomina Shahaj & Vanesa Papastavrou using simple DIC on a Nikon Ti2 with DIC at 60x1.4. 500 fps here slowed down 20 times. Processed with Nikon's denoiseAI and an unsharp mask in Fiji.
67821
Reposted by Micha Sam Brickman Raredon
Erik van Nimwegen @erikvannimwegen.bsky.social · 01/10/2026
Hey, I heard about Bonsai, but now I heard there is another method called MILK that also visualizes scRNA-seq on trees. And it is much faster! Should I just use that then? A tree is a tree, right? TLDR: No. #methodsmatter Not even close. On realistic synthetic data MILK performs worse than UMAP.
1146
Reposted by Micha Sam Brickman Raredon
NSF–DOE Rubin Observatory @rubinobservatory.org · 01/10/2026
"Let's just take a closer look." Famous last words. NSF–DOE Rubin Observatory images reveal stars, galaxy clusters, nebulae, and a mindblowing number of distant galaxies hiding in the background. 🔭🧪 So go ahead. Zoom in. You might want to clear your schedule. ➡️ skyviewer.app
16618
Reposted by Micha Sam Brickman Raredon
Benjamin @benjaminschneider.ch · 30/09/2026
Werner Herzog will be the last human being whose next word no language model can predict
9557143
Reposted by Micha Sam Brickman Raredon
Eric Topol @erictopol.bsky.social · 30/09/2026
Why do our cells age? It's not just wear and tear, accumulated damage. Loss of cell identity takes center stage. A new Nature paper and connection with prior work that substantially advances the science of aging. In the new Ground Truths. erictopol.substack.com/p/loss-of-ce...
erictopol.substack.com
Loss of Cell Identity Drives Human Aging
That’s What Biological (Epigenetic) Aging Clocks Are Measuring
817150
Reposted by Micha Sam Brickman Raredon
Alejandro Brenes @ajbrenes.com · 30/09/2026
I've used it to re analyse my neutrophil single cell proteomics data. The representation was excellent and made much biological sense. Mature neutrophils sit close together. Immature branch off. NETing populations are far off. Its great ill keep using Bonsai! Great tool!
193
Micha Sam Brickman Raredon @msbr89.bsky.social · 30/09/2026
This is very cool
030
Reposted by Micha Sam Brickman Raredon
myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 30/09/2026
www.biorxiv.org/content/10.6...
biorxiv.org
Self-centering steady-state flows emerge in confined actomyosin networks
The actin cytoskeleton drives shape changes and transport in cells and supports mechanical signal transmission. However, how cells control and use active cytoskeletal flows at the mesoscale is not wel...
033
Reposted by Micha Sam Brickman Raredon
Alfonso Martinez Arias @amartinezarias.bsky.social · 29/09/2026
Intriguing set of observations on how ‘dual-aggregate gastruloids’ lead to the emergence of foregut-pharyngeal mesoderm co-development and patterning www.biorxiv.org/content/10.6... #gastruloids #MustRead
2125
Reposted by Micha Sam Brickman Raredon
Kamryn Gerner-Mauro, PhD @kamryngerner.bsky.social · 30/09/2026
Fusion of E14 chicken parabronchi! Green staining with DSHB 7D6 for L-CAM/E-cadherin stains the lung epithelium. Magenta stains for smooth muscle actin that constricts the developing parabronchi. This was imaged on a confocal microscope and is an MIP. #ShowYourWork #SeenWithDSHB #Figure1
An image of the chicken parabronchi highlighting the interplay between smooth muscle and the epithelium during embryonic lung development. The muscle constricts the epithelium, causing it to outpocket. These outpockets will form the future gas exchange regions in the adult chicken. Green stains for DSHB 7D6 for L-CAM/E-cadherin to stain the lung epithelium. Magenta stains for smooth muscle actin that constricts the developing parabronchi.
2173
Reposted by Micha Sam Brickman Raredon
bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 29/09/2026
Cell-Hub Database: a consolidated multi-species ligand-receptor interaction resource for cell-cell communication analysis www.biorxiv.org/content/10.64898/20…
021
Reposted by Micha Sam Brickman Raredon
preLights @prelights.bsky.social · 29/09/2026
Two #preprints detail new & complementary ways to match mechanical readouts from tissues to OMICs. #preLight by @fadelvalle.bsky.social - includes a discussion with the author teams @lindithium.bsky.social @huanting-ong.bsky.social @jennyoung.bsky.social ⬇️ prelights.biologists.com/highlights/m...
prelights.biologists.com
MechanoMaST – a multimodal pipeline for spatially registering mechanical and transcriptomic tissue data; Paired-surface spatial mechanomics links tissue stiffness maps to spatial transcriptomics - pre...
Separated by only a few hours! These two novel preprints detail new and complementary ways to match mechanical readouts from tissues to OMICs
041
Reposted by Micha Sam Brickman Raredon
Miriam Quick @miriamquick.bsky.social · 29/09/2026
Love this
021
Reposted by Micha Sam Brickman Raredon
feeb | yuritober!! @magicmooshka.bsky.social · 09/01/2026
it’s come to my attention that my tumblr post has been crossposted to bluesky, so I’m posting it on my account here #AntiAI #GenAI
recently my friend's comics professor told her that it's acceptable to use gen AI for script-writing but not for art, since a machine can't generate meaningful artistic work. meanwhile, my sister's screenwriting professor said that they can use gen AI for concept art and visualization, but that it won't be able to generate a script that's any good. and at my job, it seems like each department says that AI can be useful in every field except the one that they know best.

It's only ever the jobs we're unfamiliar with that we assume can be replaced with automation. The more attuned we are with certain processes, crafts, and occupations, the more we realize that gen AI will never be able to provide a suitable replacement. The case for its existence relies on our ignorance of the work and skill required to do everything we don't.
113136026608
Reposted by Micha Sam Brickman Raredon
The Plant Journal @theplantjournal.bsky.social · 27/09/2026
𝐍𝐞𝐰 𝐬𝐩𝐞𝐜𝐢𝐚𝐥 𝐢𝐬𝐬𝐮𝐞 𝐑𝐄𝐂𝐄𝐏𝐓𝐎𝐑-𝐋𝐈𝐆𝐀𝐍𝐃 𝐈𝐍𝐓𝐄𝐑𝐀𝐂𝐓𝐈𝐎𝐍𝐒 🌱 Edited by @adsteinbrenner.bsky.social @veroglez.bsky.social @isabelmonte.bsky.social @elwirasmakowska.bsky.social 📖 Read the Editorial 👉 doi.org/10.1111/tpj.71135 🔎 Explore the complete Special Issue 👉 onlinelibrary.wiley.com/doi/toc/10.1...
doi.org
Understanding and engineering receptor–ligand interactions
Click on the article title to read more.
096
Reposted by Micha Sam Brickman Raredon
Saez-Rodriguez Group @saezlab.bsky.social · 29/09/2026
Happy to see the peer-reviewed version of SpaCEy now out: 📄 Published paper: www.nature.com/articles/s41... 💻 Code: github.com/saezlab/SpaCEy
1125
Reposted by Micha Sam Brickman Raredon
c0nc0rdance @c0nc0rdance.bsky.social · 27/09/2026
I'll save you the click-through: A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet. It's plausible that Claude found the same signatures independently...
7253111
Reposted by Micha Sam Brickman Raredon
samuel mehr @mehr.nz · 27/09/2026
another day, another bit of evidence that the scientists who willingly hand over proprietary information to AI firms may experience some consequences
7270120
Reposted by Micha Sam Brickman Raredon
Os Keyes @okeyes.bsky.social · 15/09/2026
Since we’re doing another round of “AI will destroy humanity” doom-hype, it’s a good time to announce a new paper myself and my postdoc advisor just had accepted by BioSocieties on just this. TL;DR: almost all the “AI can make bioweapons” literature comes ultimately from the Effective Altruists.
ironholds.org
17740271
Reposted by Micha Sam Brickman Raredon
Mark A. Hanson @hansonmark.bsky.social · 26/09/2026
The solution isn't obvious. The end game is to adhere to DORA, CoARA, etc... But the committees making hiring decisions are mostly treading water to understand the papers' basic premise and rarely expert enough to critique it robustly. We need to play 4D chess here: publish with non-profits. 4/n
193
Reposted by Micha Sam Brickman Raredon
Mark A. Hanson @hansonmark.bsky.social · 26/09/2026
The strain on peer review is due to our obsession of submitting *everything* to a journal and requiring PRE-PUBLICATION peer review of it before it's deemed "mature science." The problem with peer review is that no one can accept we have to stop pre-publication reviewing as default. 2/n
253
Reposted by Micha Sam Brickman Raredon
Mark A. Hanson @hansonmark.bsky.social · 26/09/2026
I'm surprised a community of publishing writers can blame AI for the problems of peer review when those same writers cite our study, "the strain on scientific publishing", which characterizes how this problem existed before AI. bit.ly/StrainQSS It's the incentives structure, not the AI. 1/n
scholarlykitchen.sspnet.org
Ask the Chefs: Peer Review Capacity — Uncomfortable Truths and Overlooked Conversations - The Scholarly Kitchen
For Peer Review Week 2026, we asked the Chefs two questions: What is one uncomfortable truth about peer review that the scholarly publishing community doesn’t talk about enough? And, beyond recruiting...
32314
Micha Sam Brickman Raredon @msbr89.bsky.social · 26/09/2026
😂
051
Reposted by Micha Sam Brickman Raredon
Hao Yin @haoyin.bsky.social · 25/09/2026
Cilia - AI champion show🏆 Credit: GPT6-Astra Inspired by @christlet.bsky.social
28320
Reposted by Micha Sam Brickman Raredon
A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 26/09/2026
#Nikon will address our concerns by next week. Hopefully the pre-processed movie & raw data will be part of that. #NikonSmallWorld
2258
Reposted by Micha Sam Brickman Raredon
Venkat Rao @venkyrao.bsky.social · 26/09/2026
Jumping on the bandwagon with a 3D view of Xenopus multiciliated cells: cilia (magenta) sprouting above the apical actin network (cyan) 🐸. Not live, but no #AISLOP
15713
Reposted by Micha Sam Brickman Raredon
Matt Henderson @matthen.com · 26/09/2026
How have the constellations changed since humans first looked up? Has the big dipper always pointed to Polaris? Has Polaris always been the North star? (nope!)
211119
Reposted by Micha Sam Brickman Raredon
Igor Adameyko @adameykolab.bsky.social · 25/09/2026
Research Briefings about our paper in Nature Genetics (atlas of human facial development): www.nature.com/articles/s41....
nature.com
Human facial development atlas illuminates enhancer-based control of facial individuality - Nature Genetics
The facial skeleton is essential for eating, breathing, kissing, speech and personal identity. Our spatiotemporally resolved cell atlas of human embryonic craniofacial development will facilitate a de...
1219
Reposted by Micha Sam Brickman Raredon
epithelial mechanics fan club @epimechfc.bsky.social · 24/09/2026
Ramos, R., Swedlund, B., Ganesan, A. K., Morsut, L., Maini, P. K., Monuki, E. S., ..., Chuong, C.-M., & Plikus, M. V. (2024). Parsing patterns: Emerging roles of tissue self-organization in health and disease. Cell, 187(13), 3165–3186. #EpithelialMechanicsReview doi.org/10.1016/j.ce...
082
Reposted by Micha Sam Brickman Raredon
Christophe 🔬 Leterrier @christlet.bsky.social · 25/09/2026
The Small World in Motion winner is now officially a "rendition" 🙄
7548
Reposted by Micha Sam Brickman Raredon
John Stott @jpsastro.bsky.social · 24/09/2026
Had a UKRI funded grant proposal rejected at the "AI triage stage". "This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review." 🧪 #academicsky
I am writing to let you know that, unfortunately, your application was not successful.

Review process

As part of the initial triage of the 179 proposals submitted to this call, each was assessed using an AI-based review. Every proposal was read independently by several different AI models against the same seven criteria used to shape this call (including cyber security relevance, research quality and novelty, importance of the problem addressed, feasibility of the project plan, likely outputs and impact, value for money, and responsible research practice), with each model asked to give a score and a written justification with supporting quotations from the text. To guard against any one model's idiosyncrasies, we also ran a second, independent process in which different AI models debated the merits and weaknesses of each proposal before reaching a judgement, again against the same criteria. Scores from both processes were combined to produce an overall ranking. 

This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review.  Projects selected for funding were drawn from those that progressed to the full human review stage. We recognise that AI-assisted assessment is a new and evolving part of the review process, and we are continuing to evaluate how well it aligns with the judgements of human reviewers on this call. We will soon produce a document detailing our method, so that others can build upon it and improve it.

Feedback on your application

Your application was not selected to progress beyond the AI triage stage.  To provide transparency on the outcome of this assessment, we are sharing below the scores (out of 5) from each of the two AI review processes described above, together with the mean score across the two processes.
40434238
Reposted by Micha Sam Brickman Raredon
MwahahahahahadScientist @mads100tist.bsky.social · 25/09/2026
This is it. This is what everyone is enabling by humoring genAI: you spend months writing something that took you years to get at, for an opaque algorithm that a few control to spit a number and cut you off right there and then. This is what we're up against 🧪
14408171
Reposted by Micha Sam Brickman Raredon
Tobias Maier @weitergen.de · 25/09/2026
In der Familie zusammen essen ist gesünder als alleine zu essen. www.science.org/doi/10.1126/... Das Paper hat den gesundheitlichen Benefit sozialer Interaktionen messbar gemacht.
science.org
Social Physiology: Human homeostasis is more efficient in social proximity
Physiological homeostasis is traditionally viewed as an individual process optimized through evolution to minimize the energetic costs of regulation. However, it remains unknown whether social proximi...
043
Reposted by Micha Sam Brickman Raredon
Lennart Hilbert @lennarthilbert.bsky.social · 24/09/2026
I hate when this happens. And, let me tell you, it happens. It’s a really bad look … omitting prior, highly relevant work is academically inappropriate, especially if it was brought to one’s attention directly. It violates commonly applicable standards and proper process.
063
Reposted by Micha Sam Brickman Raredon
Ariel M. (she/her) @byarielm.fyi · 24/09/2026
Working on getting better feeds so people can post these things and actually get seen! Here's some a few: PhD Chatter Science For You Math & Comp Bio They're still in development / testing but I saw this in Science For You feed ☺️
blacksky.community
Science For You by @byarielm.fyi
Coming soon TM
021
Reposted by Micha Sam Brickman Raredon
Christophe 🔬 Leterrier @christlet.bsky.social · 24/09/2026
I think I'm going to lose it being lectured on microscopy image presentation integrity by the winner of the Small Artificial World in Motion competition
1417833
Reposted by Micha Sam Brickman Raredon
Simon Cleary @simoncleary.bsky.social · 23/09/2026
Why would a company that sells high-end cameras and microscopes want to give the impression that we could just use computers to dream up pretty pictures for us?
042
Reposted by Micha Sam Brickman Raredon
Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 23/09/2026
The general public media now uses this video as their go to when it comes to ciliated cells. The impact is beyond this competition!
2123
Reposted by Micha Sam Brickman Raredon
Christophe 🔬 Leterrier @christlet.bsky.social · 23/09/2026
As they are not active here, I left a comment on the LinkedIn post from Nikon Small World about the concerns I think I share with many (first screenshot is their post, second screenshot is my comment) lnkd.in/p/ecdT6saZ
78917
Reposted by Micha Sam Brickman Raredon
samuel mehr @mehr.nz · 23/09/2026
"doing this wrong could end your career" raised some blood pressures lol
1101
Reposted by Micha Sam Brickman Raredon
Blake Richards @tyrellturing.bsky.social · 23/09/2026
I think the fix needs to be different for different domains. For grants & scholarships, we should move to triage + lottery. For papers, we should do post-publication public comment/review.
031
Reposted by Micha Sam Brickman Raredon
Ruben Perez-Carrasco @perez-carrasco.bsky.social · 23/09/2026
New preprint from our group disentangling stochasticity, cell-to-cell heterogeneity and interaction history in cytotoxic immune cells. Finding structure in the noise allows us to identify differences in the mechanisms of action of different antibody treatments. doi.org/10.64898/202...
doi.org
021
Reposted by Micha Sam Brickman Raredon
#SingleCell preprints @prepub-singlecell.bsky.social · 23/09/2026
Speciesformer learns conserved cellular states for cross-species generative virtual cell modeling #SingleCell 🧪🧬🖥️ www.biorxiv.org/content/10.64898/20…
011
Reposted by Micha Sam Brickman Raredon
Sara Mitri @saramitri.bsky.social · 22/09/2026
Check out @sulheim.bsky.social's paper! The latest from our lab showing that some species do actually coexist robustly, no matter what or how much you feed them, whether the environment around them is constant, and whether or not they depend on each other metabolically for amino acids and vitamins.
14415