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Linda Decker

@lindithium.bsky.social

PhD fellow in the Diz-Muñoz lab at EMBL Heidelberg interested in the mechanobiology of colorectal cancer

Linda Decker @lindithium.bsky.social · 01/09/2026

Excited to present mechanoMaST, our workflow that spatially maps AFM-based mechancis to Spatial Transcriptomics as a preprint and in a selected talk today at the @cancergrand.bsky.social Spatial Biology Conference! BioRxiv: doi.org/10.64898/202... @diz-lab.bsky.social @biorxivpreprint.bsky.social

MechanoMaST worfklow diagram. Two directly adjacent colorectal cancer liver metastasis cryosections are undergoing a different process each. In one mechanical maps are generated via AFM. In the other one the gene expression maps are generated vis Spatial transcriptomics. The generated maps from both sections are then spatially registered. Via random forest regression and differential expression analysis the biomechanome, a list of genes associated with mechanical properties can be computed.

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Linda Decker @lindithium.bsky.social · 08/07/2025

Returning inspired for science from #LINO25. Thank you to all Nobel Laureates, Organisers, Guests and fellow Young Scientists for creating such an open and supportive environment full of excitement for meaningful research.

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