POMC deficiency causes obesity in mice and humans. Here authors uncover a pivotal role of a METTL14/YTHDC1/POMC pathway, an RNA m6A modification-based mechanism, in controlling POMC neurogenesis, POMC expression, and body weight.

Antisense oligonucleotides are powerful tools for modulating gene expression. Here, the authors show that targeting transcription termination windows downstream of polyadenylation sites disrupts RNA p...

Protein synthesis declines with age across many tissues, but whether this decline actively contributes to physiological aging remains unclear. Oocytes may be particularly vulnerable because they rely ...

A key pathophysiological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is loss of nuclear localization and abnormal cytoplasmic aggregation of TAR DNA-binding prote...

Cells must prevent incompletely spliced transcripts from entering the cytoplasm, yet how splicing status is recognized and converted into selective nuclear retention remains unclear. Here, we identify...

Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the eff...

In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T...

Cryo-electron microscopy sheds light on the architecture of the Trypanosoma brucei mitochondrial editosome and reveals how this assembly mediates mRNA editing through the insertion and deletion of uri...

Chen, Hu, Zhao, Fang and colleagues show that the ribosomal large subunit protein Rpl12 functions as a conserved ribophagy receptor in multiple organisms.

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

Here, we combined ribosome profiling under conditions of mTOR inhibition and m⁶A mapping to identify distinct subsets of mRNAs that differ in their sensitivity to the suppression of cap-dependent initiation.

Here we utilize molecular dynamics simulations of FTO-RNA cap complexes to identify conserved aromatic residues on the surface of FTO involved in 5' cap recognition.

Abstract. The Arabidopsis thaliana (Arabidopsis) protein HAKAI-interacting zinc finger protein 1 (HIZ1) is both a transcriptional regulator and a component

The abundance of mRNA sets a ceiling on a cell’s capacity to produce protein and carry out its functions. Here, we describe a pathological decline in absolute mRNA abundance that occurs in most cell t...

More than twenty years ago, the FANTOM consortium uncovered that mammalian genomes are pervasively transcribed, revealing multitudes of RNAs with unknown functions. A subset of these transcripts has s...

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In this issue of Molecular Cell, Meng et al. identify a reader for pseudouridine (Ψ) in mRNA. Ψ increases binding of SMD2, a member of the SM protein ring surrounding spliceosomal U1 and U2 snRNAs, an...

Meng et al. identify SMD2 as a reader of pseudouridine (ψ) in mRNA. SMD2 colocalizes with ψ near exon-intron junctions and preferentially recognizes ψ-modified transcripts to regulate mRNA alternative splicing. SNRPD2 is highly expressed across multiple cancers, thus highlighting the therapeutic potential of targeting the ψ-SMD2 axis.

The Cancer Research UK Cambridge Institute is situated on the Biomedical Campus in Cambridge, UK. As part of the University of Cambridge, the institute's research ranges from basic biology through tra...

Adult intestinal size plasticity is driven not only by epithelial stem cells but also by remodeling of the surrounding visceral musculature. Sex- and reproduction-dependent muscle remodeling controls ...

Mu opioids, such as morphine, are effective analgesics, but their reward and tolerance drive opioid use disorder. A major goal is to achieve analgesia without these harmful effects. Here we show that ...

The roles of transposable elements in primate brain development remain underexplored. Here, the authors identify transposable elements with ancestral regulatory potential that have been co-opted as ci...

X-chromosome inactivation (XCI) enables gene dosage compensation in XX eutherians. Long interspersed element-1 (LINE-1 or L1) retrotransposons are unusually abundant on the human X chromosome and are ...

Overview of the Journal Nucleic Acids Research (NAR) is a leading open access molecular biology journal published by Oxford University Press. It provides rapid

How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3′UTR of an mRNA co-translationally chaperones the protein it encodes, preventin...

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A high-resolution developmental transcriptional atlas of the Drosophila melanogaster nerve cord identifies a shared transcriptional code that records neuronal birth order and organizes neuronal d...

Farhangmehr et al. investigate functions of highly conserved intronic sequences in cell fitness using a CRISPR-based deletion screen. Deletions in FNBP4 intron lead to changes in p53 pathway genes. De...

Elimination of all spliceosomal introns reveals a spliceosome-independent eukaryote.