Arteriosclerosis, thrombosis, and vascular biology · Xie Y, Zhao H, Lan L, Liu R, Zheng M, Zhong G, Yuan L, Li K, Macrae VE, He S, Hao Y, Yuan L, Chen G, Zhu D, Yu H.

Here, we introduce a new metric, DRACH observed/expected (DRACH o/e), to quantify the relative enrichment of DRACH motifs independently of sequence composition.

Life sciences · Wang L, Meng H, Shou Z, Bai Z, Chen C, Huang X.

Read the full paper: An Epstein-Barr virus-encoded snoRNA directs 2′-O-methylation of human rRNAs to control translation and the viral lytic switch

Cancer gene therapy · Liu H, Guo Z, Li L, Dong Y, Chen N, Yuan Z.

Bioengineered

We show that m6A stabilizes key genes and pathways promoting TMZ resistance, and that METTL3 inhibition can reverse this and restore TMZ sensitivity.

Here, we identified a structural variation (SV) in the IGF2BP1 locus-encoding an m6A reader protein-that promotes chicken muscle development through a liver-to-muscle regulatory axis.

Here, we performed two high-throughput methods established for detecting tRNA pseudouridylation positions: Nanopore direct RNA sequencing (DRS) and 2-bromoacrylamide-assisted cyclization sequencing (BACS).

Read the full paper: Characterization of Circ_0048766: an oncogenic circular rna promoting triple-negative breast cancer progression via the miR-329-3p/CXCR4 axis and regulated by METTL3

Journal of immunotherapy (Hagerstown, Md. : 1997) · Chen W.

MicrobiologyOpen · Pitt ME, Zhang J, Nguyen ANT, Hall MB, Jebeli L, Featherstone LA, Myers GSA, Scott NE, Coin LJM.

Here, we synthesize evidence suggesting that RNA modifications may form a dynamic, context-sensitive interface linking environmental inputs to phenotypic expression and developmental commitment in polyphenic systems.

Phosphorothioates, stereospecific modifications of the RNA phosphate backbone in anaerobic archaea, expand the epitranscriptome beyond nucleobases and ribose sugars. Installed by Esti enzymes at conse...

Author summary RNA molecules carry chemical modifications that act as key regulators of their function. Among the most common is m6A, which is added by several “writer” proteins. One of these writers, Mettl16, is conserved across species, yet its in vivo role remains less understood, especially in the fruit fly Drosophila. In this study, we uncover the key functions of Mettl16 in fly development and reproduction. Flies lacking Mettl16 are viable but show a range of developmental and behavioral problems. Interestingly, both males and females are sterile, with severe defects in sperm and egg production. Mechanistically, Mettl16 only methylates a small subset of mRNAs, unlike the broad activity of the major writer Mettl3. Loss of Mettl16 reduces the m⁶A modification on U6 snRNA, a core component of the splicing machinery, and affects alternative splicing on a wide scale. We propose that the diverse defects in Mettl16 mutants arise from its role in installing m⁶A on specific tr

The Tohoku journal of experimental medicine · Dan T, Zhi H, Xiuzhi Y, Yu A, Gongwei L, Qiang W, Jingxiang C.

CNS neuroscience & therapeutics · Deng H, Chen R, Qu D, Qu C, Shi J.

Seminars in cancer biology · Luo X, Zuo X, He J, Yi P.

In this study, we identify a previously unrecognized nuclear function of the cytoskeletal protein ACTB in promoting ESCC progression.

Here, we demonstrate that knockdown of Drosophila NAT10 induces an eye-to-antenna transformation, c-Jun amino-terminal kinase activation, and cell apoptosis.

RNA modifications play an important role in biological processes. Mapping the diversity of RNA chemistry and studying the biological function of in...

International immunopharmacology · Long S, Ding T, Zhou L, Gao W, Wang Q, Liu Y.

Ecotoxicology and environmental safety · Nan N, Yan Z, Li S, Qin G.

Reproductive toxicology (Elmsford, N.Y.) · Rajaipoor M, Naderi N, Tavalaee M, Nasr-Esfahani MH.

Experimental neurology · Wu Y, Zhou X, Huo X, Huang Y, Sheng D, Zeng Q.

Progress in neuro-psychopharmacology & biological psychiatry · Bi H, Sun M, Ma Q, Li X, Wang Y.

Journal of gastroenterology and hepatology · Han W, Shen Z, Zhang P.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Hao L, Zhang J, Qian Q, Jiang M, Liu Y, Geng Y, Cui N, Guo Q, Guo J.

Journal of diabetes investigation · Li L, Liu H, Mao Y, Wang H, Song L, Kang Z.

Biochemical and biophysical research communications · Wu W, Tan W, Li M, Wen X, Yan Z, Huang L, Zheng Y, Wu Q, Wu B.

Journal of hazardous materials · Wang KW, Chang W, Xiong YW, Wu XY, Li H, Du ZY, Wu LL, Zhang J, Zhu HL, Xu DX, Wang H.

Here we describe different functions of ADAR1 that nurture cancer features.

Here, we review epitranscriptomic regulation of Notch signaling, focusing on RNA modification-dependent control of the processing, localization, stability, translation, and editing of Notch-related transcripts.

Environmental toxicology and pharmacology · Zhang X, Liu N, Zhou J.

Cancer letters · Maheshwari C, Nadhan R, Nath K, Shreeshapuranik SK, Isidoro C, Song YS, Dhanasekaran DN.

Here, we identify YTHDC1, a nuclear m6A reader, as a key oncogenic factor in MM.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Abstract. Translation initiation involves a concerted set of intermolecular interactions that efficiently recognize optimal AUG start codons. However, tran

Molecular and cellular endocrinology · Xiao J, Li S, Jiang Z, Liu M, Tang J.

British journal of cancer · Huang Z, Xu W, Xiao Y, Li W, Xu M, Zhao Q, Yi P.

Biosensors & bioelectronics · Xu X, Cao L, Zheng D, Ge S, Zuo Y, Cui J, Sui J, Wang K, Li J, Wang Z, Wang X.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · Li Y, Zeng Y, Luo Q, Zhang B, Ma B, Yang X, Wang Z.

Journal of psychiatric research · Shirasath KR, Awathale SN, Goyal SN.

Alternative RNA processing generates extensive transcript diversity, yet how transcript architecture influences selective m6A deposition is incompletely understood. Exon-junction-based models explain ...