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Pawel Grzechnik

@grzechnikpawel.bsky.social
535 followers 256 following 22 posts

Group Leader and Lecturer, Division of Molecular and Cellular Function, FBMH, University of Manchester Transcription, ncRNAs and rare genetic diseases | Loves all types of martial arts www.grzechniklab.com

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Reposted by Pawel Grzechnik
Edoardo Gianni @edogia.bsky.social · 13/02/2026
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n
science.org
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
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Pawel Grzechnik @grzechnikpawel.bsky.social · 12/02/2026
Thanks, Kinga!
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Pawel Grzechnik @grzechnikpawel.bsky.social · 08/02/2026
Interested in antisense oligonucleotides? Check our story about downstream-of-gene ASOs (DG-ASOs)! Together with the Roche Innovation Center we identified transcription termination windows of protein-coding genes as ASO target regions. link to BioRxiv: www.biorxiv.org/content/10.6...
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Pawel Grzechnik @grzechnikpawel.bsky.social · 31/01/2026
Have a look at this fantastic meeting and save the date! The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK. genetics.org.uk/events/rna-i...
genetics.org.uk
RNA in physiology and disease | Genetics Society
Meeting background RNA molecules are at the heart of normal physiological processes, and their dysregulation can drive a wide range of human diseases. This international meeting will bring together wo...
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Reposted by Pawel Grzechnik
Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · 20/11/2025
Two positions (research assistant and PhD student), great science and the cake! Check @buckleylab.bsky.social thread for more info: 👇
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Reposted by Pawel Grzechnik
Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · 15/11/2025
Structural biologists! Our division has an opening for a Lecturer/Senior Lecturer—apply now! www.jobs.manchester.ac.uk/Job/JobDetai...
jobs.manchester.ac.uk
Lecturer / Senior Lecturer in Structural Biology:Oxford Road
The purpose of this post is to undertake high quality research and also excellent teaching. Hence, the ability to enhance teaching activities within our UG/PG programmes will also be expected.
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Reposted by Pawel Grzechnik
Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · 11/10/2025
21 fully funded PhD projects are available in our division! www.findaphd.com/phds/divisio...
findaphd.com
The University of Manchester, Division of Molecular and Cellular Function PhD Projects, Programmes & Scholarships - 21 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships at The University of Manchester, Division of Molecular and Cellular Function.
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Reposted by Pawel Grzechnik
Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · 17/07/2025
We are excited to announce that Professor Graham Pavitt, Chair in Molecular Biology, has been appointed as our new Head of Division! Join us in welcoming Graham to his new role—we look forward to the exciting times ahead! research.manchester.ac.uk/en/persons/g...
research.manchester.ac.uk
Graham Pavitt
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Reposted by Pawel Grzechnik
Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · 04/03/2025
Early-career fellowships at the University of Manchester! To celebrate 200 years of The University of Manchester, the Faculty of Biology Medicine and Health offers a 3-year Postdoctoral Fellowship to support exceptional early-career researchers: www.bmh.manchester.ac.uk/research/sup...
bmh.manchester.ac.uk
Bicentenary Early Career Research Fellowships | Biology, Medicine and Health | University of Manchester
Find out about and apply for a Bicentenary Early Career Research Fellowship.
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Reposted by Pawel Grzechnik
Sankari Nagarajan @sankarinagarajan.bsky.social · 04/03/2025
Exciting PhD opportunity available in my lab for the students from Black heritage background. Apply soon. 🤞🤞🤞 @mcr-breastcentre.bsky.social @mcf-uom.bsky.social CRUK Black Leaders in Cancer Non-Clinical PhD Opportunity 📅 Deadline: 4 April 🔗 crukcentre.manchester.ac.uk/study/resear...
crukcentre.manchester.ac.uk
Research Opportunities - Cancer Research UK Manchester Centre
Explore the range of postgraduate cancer research opportunities available in Manchester.
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Reposted by Pawel Grzechnik
Sankari Nagarajan @sankarinagarajan.bsky.social · 04/03/2025
Our lab's very first manuscript is out in BioRxiv. Hope this would be interesting for breast cancer scientists: www.biorxiv.org/content/10.1... @mcf-uom.bsky.social @mcr-breastcentre.bsky.social @mcrcnews.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social
biorxiv.org
Subtype-specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Gene expression is tightly controlled by DNA elements called enhancers by associating with lineage-specific transcription factors. These enhancers transcribe non-coding RNAs (called enhancer RNAs or e...
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Reposted by Pawel Grzechnik
Sankari Nagarajan @sankarinagarajan.bsky.social · 04/03/2025
A fantastic postdoc opportunity available for talented PhD graduates to work in our CRUK funded PhD project. jobs.manchester.ac.uk/internal/Job... @mcr-breastcentre.bsky.social @mcrcnews.bsky.social @mcf-uom.bsky.social @mcrcellmatrix.bsky.social @official-uom.bsky.social @fbmh-uom.bsky.social
jobs.manchester.ac.uk
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Pawel Grzechnik @grzechnikpawel.bsky.social · 28/02/2025
Which side are you on?
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Reposted by Pawel Grzechnik
Willem van Schaik @wvschaik.bsky.social · 28/02/2025
You can donate to support Ukraine's defence, humanitarian demining, medical aid, the rebuilding of Ukraine or education & science here: u24.gov.ua I just donated. Slava Ukraini!
u24.gov.ua
UNITED24 - The initiative of the President of Ukraine
UNITED24 was launched by the President of Ukraine Volodymyr Zelenskyy as the main venue for collecting charitable donations in support of Ukraine. Funds will be transferred to the official accounts of...
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Pawel Grzechnik @grzechnikpawel.bsky.social · 28/02/2025
🇺🇦
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Reposted by Pawel Grzechnik
Lea H. Gregersen @gregersenlab.bsky.social · 21/02/2025
Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @ucph.bsky.social in wonderful Copenhagen. Want to join our team to work on transcriptional regulation? More information at: gregersenlab.com Deadline March 18. Apply here: jobportal.ku.dk/phd/?show=16...
gregersenlab.com
Gegersen Lab
The aim of the lab is to understand regulation of transcription and co-transcriptional processing in human cells
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Reposted by Pawel Grzechnik
Pradeepa Madapura @pradeepmadapura.bsky.social · 13/02/2025
We are looking to recruit a highly motivated postdoc with cell or molecular biology expertise. Excellent #epigenetics, #chromatin training & networking opportunities @qmulepigenetics.bsky.social DM me for inquiries pl apply/share tinyurl.com/m6jnksk5
media.tenor.com
a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .
ALT: a cartoon of homer simpson and bart simpson sitting on a couch with the words join us above them .
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Reposted by Pawel Grzechnik
Lea H. Gregersen @gregersenlab.bsky.social · 13/02/2025
We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @ucph.bsky.social. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com). It's a wonderful city and amazing research environment. Deadline March 6. jobportal.ku.dk/phd/?show=16...
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Reposted by Pawel Grzechnik
Trends in Microbiology @cp-trendsmicrobiol.bsky.social · 06/02/2025
Pls. share: We're putting together a series on inequalities associated with academic mobility. If you're a microbiologist and would like to share your experiences with visa difficulties, travel-related funding, mandated academic mobility requirements, etc, please write at tim@cell.com. #MicroSky
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Reposted by Pawel Grzechnik
Suyang Zhang @suyangzhang.bsky.social · 03/02/2025
Ever wondered how Pol II speed is controlled during productive elongation? Our study reveals that the helicase RECQL5 triggers transcription braking, while the transcription-coupled DNA repair complex restores the elongation rate. #cryoEM #transcription www.biorxiv.org/content/10.1...
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Reposted by Pawel Grzechnik
Lovorka Stojić @loverna.bsky.social · 23/01/2025
📢1/12 Happy to share our first bluetutorial & our latest preprint. In this work, we discovered RSRC2 as a novel RNA-binding protein (RBP) with a dual function in cell division whose activity can be (lnc)RNA-mediated. #lncRNA #RBP #Mitosis www.biorxiv.org/content/10.1...
biorxiv.org
The RNA-binding protein RSRC2 promotes mitotic fidelity by interacting with the lncRNA C1QTNF1-AS1
Mitotic fidelity depends on proper chromosome alignment at the spindle equator, a process known as chromosome congression, driven by well-established protein networks. Whereas RNA-binding proteins and...
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Pawel Grzechnik @grzechnikpawel.bsky.social · 24/01/2025
We joined the Laboratory Efficiency Assessment Framework (LEAF), reduced laboratory waste and energy usage, and made the lab more sustainable overall. And so we got the LEAF GOLD award!
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Reposted by Pawel Grzechnik
Craig Kaplan @triggerloop.bsky.social · 27/11/2024
As you make have seen, there is a special issue of JMB on "Controlling Transcription Elongation and Termination: More Than a Means to An End" curated by my colleague here at Pitt Karen Arndt and by Steve Buratowski from Harvard Medical School 🧪🧵 1/ www.sciencedirect.com/science/arti...
sciencedirect.com
Controlling Transcription Elongation and Termination: More Than a Means to An End
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Reposted by Pawel Grzechnik
Craig Kaplan @triggerloop.bsky.social · 27/11/2024
Pawel Grzechnik and Hannah Mischo discuss polyadenylation site recognition and what happens afterwards and how it can go wrong: Fateful Decisions of Where to Cut the Line: Pathology Associated with Aberrant 3′ End Processing and Transcription Termination 14/ www.sciencedirect.com/science/arti...
sciencedirect.com
Fateful Decisions of Where to Cut the Line: Pathology Associated with Aberrant 3′ End Processing and Transcription Termination
Aberrant gene expression lies at the heart of many pathologies. This review will point out how 3′ end processing, the final mRNA-maturation step in th…
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Pawel Grzechnik @grzechnikpawel.bsky.social · 28/11/2024
some good reviews there!
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Reposted by Pawel Grzechnik
Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 25/11/2024
Look who's here @pnas.org ✔️ @science.org ✔️ @naturecellbiology.bsky.social ✔️ @natrevgenet.bsky.social ✔️ @naturebiotech.bsky.social ✔️ @naturemicrobiol.bsky.social ✔️ @naturechemistry.bsky.social ✔️ @genesdev.bsky.social ✔️ @cellchembiol.bsky.social ✔️ @genomeresearch.bsky.social ✔️ @jcellbiol.bsky.social ✔️
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Reposted by Pawel Grzechnik
Daniela Barillà @danielabarilla.bsky.social · 23/11/2024
📢 Interested in chromosomes and microbes thriving at the edge of life?PhD project in York-UK on chromosome segregation in #Archaea. Supervised by me, @Steve Quinn & @georgerheath.bsky.social www.findaphd.com/phds/project... Open to Applicants Worldwide! 📅 January 6, 2025 #microsky #archaeasky
Diagram showing archaeal cells containing two chromosomes bound by proteins prior to cell division.
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Pawel Grzechnik @grzechnikpawel.bsky.social · 22/11/2024
Let’s encourage our host institutes and organizations to move to Bluesky! Follow those already here (UK starter pack), and let me know about others who have joined! go.bsky.app/JMrhz8Q
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Reposted by Pawel Grzechnik
Molecular and Cellular Function, University of Manchester @mcf-uom.bsky.social · 21/11/2024
Hello, Bluesky community! We are the Division of Molecular and Cellular Function (MCF) in the Faculty of Biology, Medicine and Health at the University of Manchester. Follow us for research updates and job opportunities!
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Reposted by Pawel Grzechnik
Alper Akay @alperakay.bsky.social · 13/11/2024
go.bsky.app/77FHCU1
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Pawel Grzechnik @grzechnikpawel.bsky.social · 17/11/2024
Are there any "Bluesky transcription starter packs"?
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Pawel Grzechnik @grzechnikpawel.bsky.social · 17/11/2024
Hi All! I look forward to reconnecting with the scientific community. Bye X, enough is enough
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Pawel Grzechnik @grzechnikpawel.bsky.social · 06/04/2024
My Faculty of Biology, Medicine and Health at the University of Manchester offers Deans Prize fellowships for those aiming to establish independent research. I highly recommend applying with my Division of Molecular and Cellular Function! bmh.manchester.ac.uk/research/sup...
bmh.manchester.ac.uk
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Pawel Grzechnik @grzechnikpawel.bsky.social · 24/02/2024
2 years ago Russia attacked Ukraine. Since then @stoplab.bsky.social and her colleagues from the University of Poznan have been helping Ukrainian students maintain their education. You can help too!
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Reposted by Pawel Grzechnik
Di Jiang @dijiang319.bsky.social · 27/12/2023
A new study in Science presents an atomic detail movie of the earliest phase of gene expression when the first 17 nt of nascent RNA is synthesized. Watch a dramatic event unfolds between 9-10 nt when the transcription bubble collapses and Pol II escapes the promoter. Paper: bit.ly/adi5120 👀 movie 1
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Pawel Grzechnik @grzechnikpawel.bsky.social · 23/12/2023
So this is it for this year. A lot of ups and downs, but some amazing news at the end. Happy holidays everyone!
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Reposted by Pawel Grzechnik
Prof Anthony Isles @profantisles.bsky.social · 07/12/2023
This #postdoc position closes just after Christmas so get you applications in early to avoid disappointment! 👇🏼👇🏼
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Pawel Grzechnik @grzechnikpawel.bsky.social · 06/12/2023
Hello everyone! This place feels better...
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