In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T...

A fruit-fly protein thought only to store amino acids in fact responds to nutritional deficiency in both development and adulthood, resulting in lifespan extension.

Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the eff...

Coping with an unbalanced diet is critical in animals. However, the mechanisms that mitigate deficiencies of specific nutrients, such as choline, remain poorly understood. Choline is converted to phos...

Nature Metabolism, Published online: 01 December 2025; doi:10.1038/s42255-025-01405-8Non-nutritive sensory components of high-fat diet, such as bacon flavour, are sufficient to impair metabolic health in offspring in mice.

Background Female Aedes aegypti mosquitoes utilize host blood to support egg maturation by digesting, absorbing, and metabolizing its components. Among these, amino acids are essential as both signali...

Biological regulation is a highly intricate process and involves many layers of complexity even at the RNA level. Alternative splicing is crucial in the regulation of which components of a protein-cod...

Nature Metabolism, Published online: 17 September 2025; doi:10.1038/s42255-025-01370-2Plasma metabolic variation reflects dietary exposures. We show that biomarker panels are objective and reproducible in assessing dietary intake and quality, and can accurately predict clinical phenotypes such as diabetes and hypertension.

Scientific Reports - Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels

The role of tissue that forms between the head and trunk of a fly embryo has been unclear. It turns out that it absorbs forces when nearby cells move and divide.

「腹八分目」の戒めは、江戸時代から『養生訓』などで広く知られた健康と長寿のための経験則。20世紀に入り、ラットやミジンコといった動物を使った実験でも、食事制限…

Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.

Dietary protein sufficiency during childhood is essential for healthy growth and tissue development. Chronic protein deficiency leads to stunting, height-for-age more than two standard deviations belo...

Maintaining amino acid (AA) homeostasis is necessary for organisms. To achieve this, organisms have evolved various signalling pathways regulated by s…

Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle disease, delaying disease progression. Blocking local biosynthesis of serine challenges cellular phospholipid ho...

Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four wee...

The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.

Dietary protein restriction in healthy, lean men elicits an increased energy intake to maintain body weight, which is driven, at least in part, by FGF21-mediated alterations to adipose tissue mitochondria.

Restricting dietary protein intake has metabolic and physiological benefits for animals. Rodent studies have identified the involvement of a hormone fibroblast growth factor 21 (FGF21), which is upreg...

Mitochondria are metabolic hubs that communicate with other organelles via metabolite-, lipid-, and signaling-molecule exchange facilitated by membrane contact sites (MCSs). MCSs, regulated by tetheri...

Nature Metabolism, Published online: 14 April 2025; doi:10.1038/s42255-025-01278-xA study in Nature Metabolism reports a protein-responsive gut hormone that regulates appetite, sleep and organismal lifespan. This finding sheds light on the evolutionarily conserved endocrine system that controls dietary protein intake.

Kseniia Petrova was returning to the US from a trip to France when officials revoked her visa and detained her

Using the power of Drosophila genetics, Oi et al. identified a nonsecretory antimicrobial peptide, Attacin-D, as an essential factor in inflammatory organ damage in the renal tubules. This study highlights a key player in inflammatory organ injury.

Life activities are supported by the intricate metabolic network that is fueled by nutrients. Nutritional and genetic studies in model organisms have determined that dietary restriction and certain mu...

The serine/glycine-free diet inhibits CRC growth and enhances antitumor immunity but also promotes immune evasion through PD-L1 lactylation. It shows promise when combined with immunotherapy and has b...