Reposted by Kilchert lab
Transcription termination can be targeted by antisense oligonucleotides!
In collaboration with Roche Innovation Center Basel, we describe downstream-of-gene ASOs (DG-ASOs), which act within transcription termination windows, OUTSIDE of annotated genes.
www.nature.com/articles/s41...
nature.com
Antisense oligonucleotides targeting transcription termination windows disrupt mRNA 3’ end processing and decrease gene expression - Nature Communications
Antisense oligonucleotides are powerful tools for modulating gene expression. Here, the authors show that targeting transcription termination windows downstream of polyadenylation sites disrupts RNA p...