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Justin Mabin

@mabinjw.bsky.social

Husband, Dad, and PhD. RNA Biochemist/Bioinformatician in the Hogg lab at the NIH NHLBI, studying the effects of spliceosome dysfunction on the transcriptome.

Posts Replies Media

Reposted by Justin Mabin

Genes & Development @genesdev.bsky.social · 25/06/2026

🆕 ADVANCE ONLINE 🆕 RESEARCH PAPER: The competition between splicing and 3′ processing shapes the human transcriptome By Soles et al. and Yongsheng Shi ➡️ ow.ly/bXG150ZachI UC Irvine UC Irvine School of Medicine #RNAprocessing #splicing #mRNA #transcription

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Reposted by Justin Mabin

Cassandra Hayne @cassandrahayne.bsky.social · 25/05/2026

Looking forward to sharing this story in person at #RNASociety on Friday! I'm giving a talk at the RNA and Disease session and Liza will have a poster (ID 528) on Friday evening.

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Justin Mabin @mabinjw.bsky.social · 27/03/2026

Excited to be part of this collaborative work on telomere biology in pluripotent cells. We found that nonsense-mediated mRNA decay (NMD) becomes essential for cell survival in the absence of TRF2, by preventing production of a dominant-negative TRF1 isoform. www.nature.com/articles/s41...

nature.com

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells - Nature Cell Biology

Markiewicz-Potoczny et al. report that the nonsense-mediated mRNA decay pathway protects telomeres in the absence of core Shelterin component TRF2 by regulating the stability and abundance of TRF1 at ...

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Reposted by Justin Mabin

bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 15/03/2025

Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR www.biorxiv.org/content/10.1101/202…

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Reposted by Justin Mabin

Matthew Taliaferro @jmtali.bsky.social · 03/03/2025

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

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