The Democratic Republic of the Congo is experiencing a major outbreak of Ebola disease caused by Orthoebolavirus bundibugyoense (Bundibugyo virus), which was declared on May 15, 2026. To investigate t...

Exciting Opportunity for a PhD Researcher: Join our team to investigate molecular mechanisms in Huntington’s Disease!

We introduce a novel invariance for peptide tandem mass spectrometry data, unlocking self-supervised representation learning that improves de novo sequencing of peptides. This invariance exploits the ...

‘Wat is de Belastingdienst toch voor plek, dat dit maar blijft gebeuren?’

The prion concept postulates that seeded aggregation results in the recruitment of soluble protein monomers and their assembly into amyloid filaments with the same structures as those of the seeds. He...

Coronavirus spike proteins mediate receptor binding and fusion and are key determinants of viral host range. To bind protein receptors, some CoV spikes undergo conformational changes termed opening, w...

Mechanistic understanding of viral protein-protein interactions enables global health security and pandemic preparedness, yet experimental characterisation remains difficult, costly, and often restric...

The province is bearing an increasing share of the Ebola burden in DR Congo, while access to specialized care remains insufficient.

Emerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems coexist, but detection and data ...

Author summary Zika virus can cause neurological complications and birth defects in humans. The proteins made by viruses are the tools used to hijack human cells to repurpose them into virus productio...

Antibody numbering schemes like IMGT and Chothia assign each residue in the variable domain a consistent index based on substructural position. These annotations standardize sequences with different l...

Human seasonal influenza evolves rapidly, necessitating twice yearly decisions about whether to update the strains in the vaccine. To help inform this decision, we have been using high-throughput sequ...

During replisome assembly of monkeypox virus, the hexameric helicase–primase E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 th...

Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...

Modified nanopore simultaneously identifies diverse biomolecules and their modifications.

In maart van dit jaar kreeg Meta een gevoelige tik op de vingers van de Nederlandse rechter. Het techbedrijf moet Nederlandse gebruikers van Instagram en Facebook de mogelijkheid bieden een tijdlijn t...

Viruses are ubiquitous mobile genetic elements that are obligate symbionts of cellular life forms and replicate exclusively within host cells. The ...

Cell entry of nonenveloped animal viruses requires translocation of a macromolecular assembly across a cellular membrane. Double-stranded RNA viruses introduce into the target cell an inner capsid par...

During Ebolavirus transit through the endo-lysosomal pathway, the glycoprotein GP undergoes a series of conformational rearrangements upon cathepsin cleavage and NPC1 receptor binding, culminating in host-virus membrane fusion. While these rearrangements underpin viral entry, their molecular mechanisms remain poorly understood. Here, we combine hydrogen/deuterium-exchange mass spectrometry and mass photometry to resolve structural dynamic and energetic transitions of GP of two major species, Zaire (EBOV) and Sudan (SUDV). We describe the allosteric axes that govern reorganization of the cleavage sites, opening of the receptor binding cavity and priming for fusion upon NPC1 engagement. We show that GP cathepsin cleavage and receptor binding exhibit different mechanisms and kinetics across species, and are allosterically coupled in a species-specific manner. We reveal that fusion priming is optimized via distinct routes in EBOV and SUDV GP. These data suggest that GP structural dynamics and allosteric remodelling underlie differences in entry mechanisms across Ebolavirus species.