The late-night host said his interview with the Texas Democratic Senate candidate would air instead on YouTube.

Characterization of the human coronavirus HKU1 is limited due to a lack of infection models. Here, the authors develop a cell model to propagate HKU1 and show that, unlike its relative SARS-CoV-2, it ...

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The manchette is a transient microtubule (MT)-based structure that is vital for the correct shaping of sperm during spermiogenesis. Throughout spermiogenesis, the manchette retains structural integrity for several days, raising the question of how its MTs are regulated. Here, using cryo-electron tomography of manchettes isolated from rat testes, we find that manchette MT ends are structurally diverse. We show that the MT-binding protein CLASP2 is present throughout the manchette and likely regulates both MT ends. Using cryo-electron microscopy single particle analysis and super-resolution microscopy, we reveal that SPACA9 and MNMIP1 (SH3D21) bind to the seam of manchette MTs from the luminal side. SPACA9 binds to both α- and β-tubulin of protofilament 1 but does not interact directly with protofilament 13, while MNMIP1 binds directly to protofilament 13. MNMIP1 further extends and threads through the MT lattice at the seam. Our study reveals a novel seam MT inner protein complex with a unique binding mode, providing a plausible explanation for MT regulation that maintains manchette integrity over an extended period.

Join our team to contribute to the operation and innovation of state-of-the-art cryo-electron microscopes and empower groundbreaking research.

High-temporal-resolution fluorescence measurements reveal how quickly proteins cross energy barriers separating unfolded and folded states.

Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55

In memoriam: prof. dr. Hans Vliegenthart (April 7, 1936 – February 12, 2026)

To understand how proteins function, we need to know their three-dimensional structure. We use two techniques to determine such 3D structures of proteins and their complexes: X-ray crystallography and...

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...