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Harvard Cryo-EM Center for Structural Biology

@hc2em.bsky.social

Consortium formed by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital. cryoem.hms.harvard.edu

Posts Replies Media

Reposted by Harvard Cryo-EM Center for Structural Biology

Daniel Hurdiss @danielhurdiss.bsky.social · 03/09/2026

Structure and operating principles of a monkeypox virus replisome | @nature.com www.nature.com/articles/s41...

nature.com

Structure and operating principles of a monkeypox virus replisome - Nature

During replisome assembly of monkeypox virus, the hexameric helicase–primase E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 th...

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Reposted by Harvard Cryo-EM Center for Structural Biology

cryoEM papers @cryoempapers.bsky.social · 23/07/2026

Blm10 and PI31 comprise a failsafe mechanism for proteasome inhibition pubmed.ncbi.nlm.nih.gov/42485378/ #cryoEM

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Reposted by Harvard Cryo-EM Center for Structural Biology

Abraham lab at Harvard Medical School @abrahamlabhms.bsky.social · 30/07/2026

We used cryo-EM at @hc2em.bsky.social to visualize how alphaviruses bind the mosquito receptor. Lachesin binds within the cleft of adjacent E2–E1 heterodimers, which is also a site where CHIKV binds MXRA8, a receptor on human cells.

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Reposted by Harvard Cryo-EM Center for Structural Biology

Lucas Farnung @lucas.farnunglab.com · 12/12/2024

Thank you, @hc2em.bsky.social! The entire team made this possible! You are amazing.

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Reposted by Harvard Cryo-EM Center for Structural Biology

cryoEM papers @cryoempapers.bsky.social · 17/12/2024

Cryo-EM Structure of Recombinantly Expressed hUGDH Unveils a Hidden, Alternative Allosteric Inhibitor pubmed.ncbi.nlm.nih.gov/39680853/

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Harvard Cryo-EM Center for Structural Biology @hc2em.bsky.social · 14/02/2024

Roses are red Violets are blue If you love Cryogenic Electron Microscopy This job ad is for you: jobs.brassring.com/1033/ASP/TG/...

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Reposted by Harvard Cryo-EM Center for Structural Biology

Susan Shao @sshaolab.bsky.social · 03/01/2024

A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes Learn more here! rdcu.be/du2ZX

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Reposted by Harvard Cryo-EM Center for Structural Biology

Lucas Farnung @lucas.farnunglab.com · 08/12/2023

Our paper on the structure of the complete Rpd3S-nucleosome complex is now out in Nat Comm: rdcu.be/ds6k1 . Congrats to @jonmarkert.bsky.social and co-corresponding author Seychelle Vos! This is the second HDAC-nucleosome structure from Jon this year. Amazing!

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Reposted by Harvard Cryo-EM Center for Structural Biology

Lucas Farnung @lucas.farnunglab.com · 03/10/2023

Thrilled to announce that I have been awarded the NIH Director's New Innovator Award from NIH_CommonFund to study processes at the nexus of chromatin, transcription, and epigenetics. Thank you to my lab, former and current mentors, and the support by the Department of Cell Biology at HMS!

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