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Ian Wong Lab at Brown University

@ianywonglab.bsky.social
1.2K followers 371 following 67 posts

Biomedical engineering lab at Brown University. Biomaterials, mechanobiology and computer vision for cancer cell invasion. Also, micro / nano fab and 3D printing.

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Reposted by Ian Wong Lab at Brown University
Science Magazine @science.org · 01/10/2026
Here's a reminder on #InternationalCoffeeDay: It's OK to take a (coffee) break. ☕ "It’s ... helpful to have a venue to share the day-to-day ups and downs of life as a grad student." scim.ag/4xMyqZO
People arm in arm while drinking coffee and holding papers, with the headline: Why scientists should take more coffee breaks
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 28/09/2026
Check out our News and Views in Nature Nanotech led by postdocs @htjeong.bsky.social and @jiwon-kim.bsky.social , highlighting deformable microparticles that transduce mechanical compression into MRI contrast, mapping dynamic stresses deep inside tumors @natnano.nature.com rdcu.be/XyYh3fHsAD4a
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 24/09/2026
Visited Harvard to give a Squishy Physics talk. Reminiscing about my early days learning from this incredibly talented group - Margaret Gardel, Megan Valentine, Cliff Brangwynne, Jennifer Shin, Dave Weitz and so many others.. @squishycell.bsky.social, @brangwynnelab.bsky.social
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Reposted by Ian Wong Lab at Brown University
Brown University School of Engineering @brownengineering.bsky.social · 16/09/2026
Hibbitt Postdoc Jiwon Kim was selected as a ⭐2026 Rising Stars Women in Engineering⭐ by the Asian Deans’ Forum. This workshop is organized by leading engineering schools in the Asia Pacific region. Kim, of @ianywonglab.bsky.social, was also a 2025 MIT Rising Star in Mechanical Engineering.
Jiwon Kim was selected as a 2026 Women in Engineering Rising Star by the Asian Deans Forum. She was honored in Hong Kong Sept. 13-15, 2026.
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Reposted by Ian Wong Lab at Brown University
Science Magazine @science.org · 08/09/2026
Neutrophils remodel their actin cytoskeleton rapidly as they navigate narrow capillaries of varying sizes, enabling them to squeeze through without causing blockages. Learn more in #ScienceImmunology: scim.ag/4xwpB7e
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 30/08/2026
A new semester begins!
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Reposted by Ian Wong Lab at Brown University
Brown University School of Engineering @brownengineering.bsky.social · 21/07/2026
Associate Professor Ian Y. Wong (@ianywonglab.bsky.social) has been named to the editorial board of the @annualreviews.bsky.social of Biomedical Engineering. engineering.brown.edu/news/2026-07...
engineering.brown.edu
Wong joins Editorial Board of Annual Review of Biomedical Engineering
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Reposted by Ian Wong Lab at Brown University
Teng-Leong Chew @scopeshifu.bsky.social · 15/07/2026
🧪 @aicjanelia.bsky.social and @scientistrachel.bsky.social have just published a new quantitative tool, OpticalFlow3D, for tracking amorphous motion in 3D. Try it out and let us know what you think! tinyurl.com/OpticalFlow3D
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 14/07/2026
looking forward to my online talk for the Journal of Biological Physics on 23 July at 4:00 PM (Europe/Berlin). cassyni.com/events/GVxaf...
cassyni.com
Collective transitions from orbiting to matrix invasion in three-dimensional multicellular spheroids
Coordinated cell rotation along a curved matrix interface can sculpt epithelial tissues into spherical morphologies. Subsequently, radially oriented invasion of multicellular strands or branches can o...
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 19/06/2026
New preprint! We show all-electrical, label-free imaging of single cell migration on a CMOS chip - no optics whatsoever! Fun collaboration led by Hyuntae Jeong with Pushkaraj Joshi and Jacob Rosenstein @htjeong.bsky.social @brownengineering.bsky.social www.biorxiv.org/content/10.6...
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Reposted by Ian Wong Lab at Brown University
bioRxiv Bioengineering @biorxiv-bioeng.bsky.social · 17/06/2026
Label-Free All-Electrical Tracking of Individual and Collective Cell Migration on a Megapixel CMOS Capacitance Sensor www.biorxiv.org/content/10.64898/20…
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Reposted by Ian Wong Lab at Brown University
Henry De Belly @henrydebelly.bsky.social · 10/06/2026
Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
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Reposted by Ian Wong Lab at Brown University
epithelial mechanics fan club @epimechfc.bsky.social · 02/06/2026
Rodriguez, C., Jeong, H., Kim, J., ... & Guo, M. (2026). Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D. Biophysical Journal. #EpithelialMechanics doi.org/10.1016/j.bp...
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Reposted by Ian Wong Lab at Brown University
VickySanzMoreno @vickysanzmoreno.bsky.social · 29/05/2026
Delighted to share our latest views on our favourite cancer cells Well done @ritoghose.bsky.social 👏 @icr.ac.uk @breastcancernow.bsky.social Amoeboid cancer cells at a glance journals.biologists.com/jcs/article/...
journals.biologists.com
Amoeboid cancer cells at a glance
Summary: Amoeboid cancer cells exploit actomyosin contractility, metabolic adaptability and immune evasion to drive metastasis, representing a distinct and therapeutically targetable state within the ...
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 21/05/2026
Enjoyed a stimulating cell migration + math bio conference at the Banff International Research Station. Many thanks to the organizers and congratulations to @htjeong.bsky.social and @jiwon-kim.bsky.social for great talks! Look forward to visiting again soon!
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Reposted by Ian Wong Lab at Brown University
American Society for Cell Biology @ascbiology.bsky.social · 05/05/2026
Editor Spotlight: Leah Edelstein-Keshet University of British Columbia “MBoC provides excellent examples of quantitative reasoning in cell biology and helps advance this growing area of the field.” Explore the journal and submission opportunities at molbiolcell.org
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Reposted by Ian Wong Lab at Brown University
Pablo J. Sáez @pjsaez.bsky.social · 27/04/2026
Very nice cover picture for the next GRC in #CellMigration, chaired by @robinsall.bsky.social #AnaMariaLennon & @djcohen.bsky.social www.grc.org/directed-cel...
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Reposted by Ian Wong Lab at Brown University
Johanna Joyce @johannajoyce.bsky.social · 16/04/2026
What does it take to truly understand #cancer in all of its complexity? Delighted to share our Review in Cell "Cancer ecosystems: A dynamic interplay across scales" with Daniela Quail, where we propose a multi-scale framework connecting tumor ecology with physiology 🧪⚕️ www.cell.com/cell/fulltex...
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Reposted by Ian Wong Lab at Brown University
Science Magazine @science.org · 13/04/2026
Tumor cells often metastasize in clusters with other cells, offering novel targets for treatments. Learn more: scim.ag/4vGFV50
Cancer’s cluster bombs
The bloodstream is a dangerous environment for a solo cancer cell. Wandering tumor cells often huddle together, thereby boosting their chances of arriving at a promising location to start a new tumor.
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Reposted by Ian Wong Lab at Brown University
epithelial mechanics fan club @epimechfc.bsky.social · 12/04/2026
Much remains to be explored. What happens when the tissue geometry is more complex? Does this occur more broadly for other biomaterials? Could we one day control collective orbiting for development and disease? We are excited to chat about epithelial mechanobiology www.instagram.com/reel/DQUBGUE...
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Reposted by Ian Wong Lab at Brown University
epithelial mechanics fan club @epimechfc.bsky.social · 12/04/2026
How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology! Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.
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Reposted by Ian Wong Lab at Brown University
bioRxiv Biophysics @biorxiv-biophys.bsky.social · 09/04/2026
Partial EMT Drives Persistent Collective Migration via Collision Guidance in Heterogeneous Populations www.biorxiv.org/content/10.64898/20…
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Reposted by Ian Wong Lab at Brown University
epithelial mechanics fan club @epimechfc.bsky.social · 08/04/2026
Kim, J., Jeong, H., Falcó, C., Hruska, A. M., Martinson, W. D., Marzoratti, A., ... & Wong, I. Y. (2026). Collective transitions from orbiting to matrix invasion in three-dimensional multicellular spheroids. Nature Physics, 1-12. #EpithelialMechanics buff.ly/ChmS1uW
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 02/04/2026
Delighted to announce the Microtechnologies in Medicine and Biology (MMB 2026) conference in Maui this December 7-11 (mmb2026.org) - continuing a series of Hawaii conferences that bring together thought leaders in tiny technologies to transform biomedicine. Abstracts due July 1, 2026.
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Reposted by Ian Wong Lab at Brown University
Jorge Díaz @jorgediazfuentes.bsky.social · 23/03/2026
Collective migration is not just about leaders at the front, but about coordination across the group. Always exciting to see these dynamics visualized. Many thanks to @jcb.org for featuring our work 🐸🔬🌹
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Reposted by Ian Wong Lab at Brown University
Science Magazine @science.org · 09/03/2026
Of the many impressive acrobatic qualities of cats, perhaps their most spectacular is their ability to right themselves midair so they always seem to land on their feet. The trick lies in a hyperflexible region of their backbone known as the thoracic spine, a new study finds. scim.ag/4rlHodw
Do the twist: Scientists reveal why cats always land on their feet
Study of feline spines suggests a hyperflexible region of their backbones is key
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 05/03/2026
a temporary addition to the campus architecture..
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Reposted by Ian Wong Lab at Brown University
Johanna Ivaska @johannaivaska.bsky.social · 20/02/2026
What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity! www.nature.com/articles/s41...
nature.com
Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials
Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 07/02/2026
Snowy night @brownengineering.bsky.social
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Reposted by Ian Wong Lab at Brown University
Sri Narasimhan @snarasimhan.bsky.social · 29/01/2026
Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex... This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011. @cp-cell.bsky.social @cellpress.bsky.social
cell.com
Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabilit...
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 26/01/2026
and the Brown news release on our Nature Physics paper: www.brown.edu/news/2026-01...
brown.edu
The shape of things to come: How spheroid geometry guides multicellular orbiting and invasion
In research that could shed light on the growth and formation of complex tissue architectures, Brown University engineers show how cells orbit and reconfigure their surroundings to venture outward fro...
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 26/01/2026
Published online today in Nature Physics - we show how multicellular spheroids round up and orbit, driving a deterministic transition to 3D matrix invasion at predictable locations. Amazing work from @jiwon-kim.bsky.social, @htjeong.bsky.social and collaborators www.nature.com/articles/s41...
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Reposted by Ian Wong Lab at Brown University
Nature Materials @natmater.nature.com · 23/01/2026
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells go.nature.com/4jZ8OUu
go.nature.com
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells - Nature Materials
The viscosity of tumour cells is shown to govern their ability to disseminate through the bloodstream and extravasate, establishing a key biomechanical factor of metastasis.
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Reposted by Ian Wong Lab at Brown University
Rockefeller University Press @rupress.org · 21/01/2026
In @jcb.org, Diaz & @mayorlab.bsky.social show that epithelial & mesenchymal cells navigate chemical cues via fundamentally different force-generating mechanisms, offering new insight into how diverse cell types achieve collective movement during development and disease. rupress.org/jcb/article/...
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Reposted by Ian Wong Lab at Brown University
Nature @nature.com · 12/01/2026
This octopus-camouflage inspired polymer can change colour and texture
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Reposted by Ian Wong Lab at Brown University
Anne Straube @anne.mechanochemistry.org · 06/01/2026
Our paper describing the development of ShapeSpaceExplorer is now out: journals.plos.org/ploscompbiol... The software and documentation is available here: github.com/cmcb-warwick... Explainer thread below.
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Reposted by Ian Wong Lab at Brown University
Jorge Barrasa Fano @barrasa-fano.bsky.social · 05/01/2026
I'm very happy to share my first article as a corresponding author published in @natmethods.nature.com !! 😍 Some groups (like us) have developed complex 3DTFM methods in the last 15 years. BUT its usage in studies that help better understand disease or development has been almost non-existent.
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 15/12/2025
Belated post on lab alum Susan Leggett Ph.D. '18, featured by Matter as an emerging investigator in materials under 35. @brownengineering.bsky.social www.cell.com/matter/fullt...
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Reposted by Ian Wong Lab at Brown University
Andy Moore @aaandmoore.bsky.social · 25/11/2025
I like this movie, but a friend of mine likes to complain about the obvious stitching artifacts. I'll try harder next time, Michael. Vimentin (orange) and ER (blue) in an overnight acquisition.
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Reposted by Ian Wong Lab at Brown University
Stephanie Woo @itsthewoolab.bsky.social · 05/12/2025
New paper alert! We report that #zebrafish endodermal cells use contact inhibition of locomotion as a dispersal and spacing mechanism. It’s a neat example of large-scale patterns emerging from local interactions using a simple set of rules. Summary in the thread below 1/9 doi.org/10.1016/j.is...
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 04/12/2025
Beautiful visualization of cancer cell metastatic colonization depicted by Brown's undergrad-led SciToons program @weldeiry.bsky.social #LegorretaCancerCenter www.youtube.com/watch?v=W8P-...
youtube.com
How a Cancer Cell Sets Up Basecamp
YouTube video by SciToons
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Reposted by Ian Wong Lab at Brown University
Journal of Cell Science @jcellsci.bsky.social · 02/12/2025
In their Tools and Resources article, Nina Grishchenko, Michael Olson and colleagues present Toogle-Untoogle, a cell segmentation tool with an interactive user verification interface. journals.biologists.com/jcs/article/...
Figure showing the interactive segmentation refinement in Toggle-Untoggle – de-selection, merging and manual annotation.
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Ian Wong Lab at Brown University @ianywonglab.bsky.social · 01/12/2025
www.nature.com/articles/s41...
nature.com
Following a cell’s every move - Nature Methods
Identifying individual cells and tracking their movements over time are two critically important tasks in bioimage analysis. We discuss a fresh wave of tools that push these techniques toward peak per...
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Reposted by Ian Wong Lab at Brown University
Science Magazine @science.org · 27/11/2025
The domestic cat may be a far more recent arrival to Europe than previously thought, a new Science study. finds. The results offer new insight into one of humanity’s most enigmatic animal companions and identify North Africa as the cradle of the modern housecat. Learn more: scim.ag/44kov1S
A shorthair domestic cat gazes upward.
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Reposted by Ian Wong Lab at Brown University
Andy Moore @aaandmoore.bsky.social · 23/11/2025
Still posting cytoskeleton videos, it seems. Actin this time. Sample: Lifeact-eGFP in HeLa cells. Modality: Airyscan confocal Timestamp is mm:ss and the scale bar is 5 µm.
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Reposted by Ian Wong Lab at Brown University
Manuel Thery @manuelthery.bsky.social · 21/11/2025
The law of the jungle. Interactions of cells in a collective lead to global rotation. In 80% of the case HUVEC cells turn clockwise. How many cells does it take for this to happen?
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Reposted by Ian Wong Lab at Brown University
Pablo J. Sáez @pjsaez.bsky.social · 14/11/2025
I guess it never gets old...bc we love #CellMigration ATP has many roles: energy currency, hydrotrope, and *danger signal* Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost! www.science.org/doi/full/10.... @focalplane.bsky.social #fluorescencefriday 🧪🔬
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Reposted by Ian Wong Lab at Brown University
Lori O'Brien @llobrienlab.bsky.social · 07/11/2025
Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.
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Reposted by Ian Wong Lab at Brown University
Sam Connell @samuelconnell.3i.social · 13/11/2025
What a crazy cool paper! First author @pierreucla.bsky.social with a large crew knocked it out of the park. (GIF below from @the.3i.social LLS) Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays www.pnas.org/doi/10.1073/...
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Reposted by Ian Wong Lab at Brown University
Anjali Sharma @anjalisharma.bsky.social · 11/11/2025
Comment by Prof @icouzin.bsky.social that explores how collective intelligence emerges from local interactions in animal groups, and how these principles inform the design of swarm robotic systems. @natureportfolio.nature.com @natcomms.nature.com #robotics www.nature.com/articles/s41...
nature.com
Collective intelligence in animals and robots - Nature Communications
This commentary explores how collective intelligence arises from local interactions in animal groups and how these principles inform the design of swarm robotic systems, addressing the challenge of ac...
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