Sign in

Wafik S. El-Deiry, MD, PhD, FACP

@weldeiry.bsky.social
803 followers 190 following 3.6K posts

Physician-Scientist Oncologist, Director Legorreta Cancer Center, Associate Dean, past Faculty Exec Cmte member, Brown Univ, ACS Professor, Chair, WIN Consortium in Precision Oncology, Entrepreneur, Boat Captain, joined Nov 16 ‘24 Pubs: tinyurl.com/s98xg3u

PostsRepliesMedia
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 22/09/2026
Family sounds alarm after 83-year-old grandma dies under Canada's assisted-death program www.foxnews.com/media/family...
foxnews.com
Family sounds alarm after 83-year-old grandma dies under Canada's assisted-death program
Brigitte Stegemann's granddaughter alleges the 83-year-old became distraught and said she "made a mistake" days before her MAiD procedure in Ontario.
001
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 16/09/2026
First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis www.cell.com/cell-reports...
cell.com
First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis
Wang et al. report the efficacy of a preliminary cohort of patients who receive first-line fecal microbiota transplantation for the management of immune-mediated diarrhea and colitis with multi-omics ...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/09/2026
I enjoyed as part of my role as a physician writing prescriptions by hand for patients until it was no longer the way medicine is practiced in the US.
110
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/09/2026
Inhibitory circuits restrain adult glioma progression by suppressing calcium-driven oncogenic programs www.cell.com/neuron/abstr...
cell.com
Inhibitory circuits restrain adult glioma progression by suppressing calcium-driven oncogenic programs
Uesaka et al. show that inhibitory brain circuits can suppress adult glioma growth by limiting tumor calcium signaling and downstream growth programs. The study reframes glioma progression as a balanc...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/09/2026
The neurons that can put a brake on a nervous-system cancer Drugs that imitate the effect of GABAergic neurons slow the growth of tumours called gliomas in mice. x.com/nature/statu...
x.com
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/09/2026
Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy x.com/nejm/status/...
x.com
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/09/2026
A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer link.springer.com/article/10.1...
link.springer.com
A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer - Molecular Cancer
Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/09/2026
Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent www.science.org/doi/10.1126/...
science.org
Early detection of invasive lung cancer and multiorgan metastasis by a collagen-targeted protein MRI contrast agent
Lung cancer with multiorgan metastasis remains the leading cause of cancer death. Current CT imaging and biopsy are suboptimal for detecting early tumors or subclinical metastases. We address this gap...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/09/2026
Working on important manuscripts today in pursuit of novel cancer treatments and strategies for precision cancer therapeutics. There is so much to be done In oncology and cancer research.
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/09/2026
Top AI leaders unite to warn the technology is advancing too fast Dario Amodei, Sam Altman and Elon Musk, long at odds with each other, found common ground in calling for a slowdown in AI amid mounting fears about its dangers. www.washingtonpost.com/technology/2...
washingtonpost.com
Top AI leaders unite to warn the technology is advancing too fast
Dario Amodei, Sam Altman and Elon Musk, long at odds with each other, found common ground in calling for a slowdown in the advancement of AI amid mounting fears about its dangers.
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 12/09/2026
Machine Learning–Designed Individualized Neoantigen Therapy Improves Recurrence-Free Survival in Resected Melanoma ascoai.org/articles/202...
ascoai.org
Machine Learning–Designed Individualized Neoantigen Therapy Improves Recurrence-Free Survival in Resected Melanoma
020
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 12/09/2026
Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte–mediated cancer immunotherapy www.science.org/doi/10.1126/...
science.org
Targeting tumor-associated macrophages using mRNA lipid nanoparticles for cytotoxic T lymphocyte–mediated cancer immunotherapy
The immunosuppressive tumor microenvironment (TME) remains one of the main obstacles that limit responsiveness to immunotherapy. Recently, lipid nanoparticles carrying messenger RNA (mRNA) have emerge...
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 12/09/2026
Targeted mRNA Nanoparticles Turn Tumor Macrophages Against Cancer www.insideprecisionmedicine.com/topics/oncol...
insideprecisionmedicine.com
Targeted mRNA Nanoparticles Turn Tumor Macrophages Against Cancer
Targeted mRNA nanoparticles reprogrammed tumor-associated macrophages and increased the infiltration and activity of cancer-fighting T cells in mice.
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 12/09/2026
IL1RAP-expressing myeloid-stromal networks represent a therapeutic vulnerability to improve chemoimmunotherapy sensitivity in pancreatic cancer insight.jci.org/articles/vie...
insight.jci.org
JCI Insight - IL1RAP-expressing myeloid-stromal networks represent a therapeutic vulnerability to improve chemoimmunotherapy sensitivity in pancreatic cancer
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 12/09/2026
Scientists find a way to break pancreatic cancer’s protective shield www.sciencedaily.com/releases/202...
sciencedaily.com
Scientists find a way to break pancreatic cancer’s protective shield
Researchers found that blocking IL1RAP could disrupt a powerful inflammatory network that helps pancreatic cancer survive treatment. In preclinical experiments, the approach reduced tumor-protecting c...
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 12/09/2026
Cancer treatment alters mutant selection in normal esophagus www.nature.com/articles/s41...
nature.com
Cancer treatment alters mutant selection in normal esophagus - Nature Genetics
Cancer treatment alters the selection of preexisting somatic mutations in the normal esophagus, including druggable mutants that confer treatment resilience to normal cells.
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 12/09/2026
Global Precision Oncology meeting👇 Upcoming @WIN_Consortium Symposium in Providence, RI October 2-3, 2026. mcigroup-winsymposium2026.eventsairsite.com
011
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 10/09/2026
U.S. cancer institute director counters gloomy forecast Anthony Letai denies political interference during his first year and says NCI's grant numbers are up again www.science.org/content/arti...
science.org
U.S. cancer institute director counters gloomy forecast
Anthony Letai denies political interference during his first year and says NCI's grant numbers are up again
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 10/09/2026
Political world erupts as AI researchers warn of ‘extinction’ threat Anthropic has built its reputation as the safety-minded AI company. But some of its own researchers fear the race it has joined could end with humanity’s destruction. www.washingtonpost.com/technology/2...
washingtonpost.com
Political world erupts as AI researchers warn of ‘extinction’ threat
Anthropic has built its reputation as the safety-minded AI company. But some of its own researchers fear the race it has joined could end with humanity’s destruction.
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 09/09/2026
Attended, as Secretary of the Faculty, the first university-wide faculty meeting for the academic year at on Brown’s College Hill campus in Providence, RI. The meeting had a celebratory tone with newly appointed and promoted faculty. Exciting year up ahead at @BrownUniversity which brings me hope.
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 09/09/2026
“But if you're a researcher and you just watched this happen, I don't think you'd keep your best ideas inside someone else's product.” OpenAI fought dirty on career-making math problem, says NYU mathematician techcrunch.com/2026/09/08/o...
techcrunch.com
OpenAI fought dirty on career-making math problem, says NYU mathematician | TechCrunch
There is a $1 million bounty for the first person providing a solution to the Navier-Stokes existence and smoothness problem.
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 07/09/2026
Research brings hope for precision cancer therapy. @WIN_Consortium
110
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 01/09/2026
Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study ascopubs.org/doi/10.1200/...
ascopubs.org
Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study
PURPOSELaser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the LAANTERN prospective multicenter registry (ClinicalTrial...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 01/09/2026
Novartis Pauses Autoimmune CAR-T Cell Therapy Studies After Deaths Bristol-Myers Squibb also pauses similar trials as a precautionary measure www.wsj.com/health/pharm...
wsj.com
Novartis Pauses Autoimmune Cell Therapy Studies After Deaths
Novartis paused eight clinical trials of an experimental therapy targeting autoimmune and neurological disorders in late August, after three patients died.
210
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 30/08/2026
Cruising Rhode Island waters on a Sunday, Summer 2026.
020
Reposted by Wafik S. El-Deiry, MD, PhD, FACP
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 09/05/2025
I don't believe that most science is fraudulent as I have said before. To believe otherwise is misguided and misleads both the public and regulators.
142
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 02/08/2026
It is notable to hear Dr. Ashish Jha say he now believes the COVID pandemic was most likely the result of a lab leak. And it is also important to hear him say that gain-of-function research is a global issue that should be addressed as such. I fully agree. x.com/ashishkjha/s...
x.com
Ashish K. Jha (@ashishkjha) on X
On @CNNSOTU with @DanaBashCNN this morning. I said three things: 1. Political leaders are accountable for public health decisions, not the scientists who advise them 2. The vaccine-autism question h...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 13/07/2026
Concerned about the future of science in America.
020
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 08/06/2026
I will disconnect at this time. Social Media takes too much of my precious time. Any time I have I would like to invest in science and medicine. And any posts will be strictly focused on discoveries and advances in cancer research and oncology. Thank you.
020
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 04/06/2026
Here are images of two cancers that developed in the injected arm after COVID mRNA injections; lymphoma and sarcoma. link.springer.com/article/10.1... pmc.ncbi.nlm.nih.gov/articles/PMC...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 01/06/2026
Practice-changing results reported for Revolution Medicines pancreatic cancer drug www.statnews.com/2026/05/31/p...
statnews.com
Practice-changing results reported for Revolution Medicines pancreatic cancer drug
Much-awaited results at ASCO show that scientists have indeed found a way to drug a "greasy ball" involved in pancreatic cancer.
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 01/06/2026
Daily pill doubles survival time for pancreatic cancer patients www.bbc.com/news/article...
bbc.com
Daily pill daraxonrasib doubles survival time for pancreatic cancer patients
The drug, daraxonrasib, has been hailed as a breakthrough in managing the deadliest of all the major cancers.
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 01/06/2026
Daily pill can double survival time for world’s deadliest cancer, trial shows Experts hail daraxonrasib as ‘gamechanger’ for patients with advanced pancreatic cancer www.theguardian.com/society/2026...
theguardian.com
Daily pill can double survival time for world’s deadliest cancer, trial shows
Experts hail daraxonrasib as ‘gamechanger’ for patients with advanced pancreatic cancer
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 23/05/2026
Nearly a decade ago in 2017 I wrote about needed improvements to electronic health record systems but in 2026 we still scan faxed records into an EHR that is often very difficult to access including pathology images that are still not electronically accessible. www.linkedin.com/pulse/what-d...
linkedin.com
What does a better EHR look like?
I tweeted recently "It is sad that electronic health records are designed around billing, not optimal patient care, utility, provider efficiency or satisfaction" (https://twitter.com/weldeiry/status/9...
110
Reposted by Wafik S. El-Deiry, MD, PhD, FACP
American Society of Clinical Oncology @ascocancer.bsky.social · 20/05/2026
We’re pleased to announce our Featured Voices for #ASCO26! Get their expert insights into the science & ed sessions, what they view as practice changing & how they’ll bring what they’ve learned into the clinic. Follow & be a part of the conversation using the meeting hashtag. bit.ly/4uln3XV
073
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 20/05/2026
Passing through Philly on way to LAX with some delays.
040
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 19/05/2026
Save the Date for 2026 @WIN_Consortium Symposium in Rhode Island October 2-3, 2026. @Dr_R_Kurzrock @AACRPres @realrickpazdur @SewantiLimaye @DrRoyHerbst @LussierY @LiaTsimberidou @bcarneiro7 @LiangChengMD @RueterJens @alshamsi2000 @JiaJennyLiu @VivekSubbiah @billdahutmd @DrJoannSweasy
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 18/05/2026
Voluntary healthcare cost limits aren’t working. Should Rhode Island’s insurers face sanctions? As spending skyrockets, health insurance commissioner report recommends adding teeth to spending growth targets rhodeislandcurrent.com/2026/05/18/v...
rhodeislandcurrent.com
Voluntary healthcare cost limits aren’t working. Should Rhode Island's insurers face sanctions? • Rhode Island Current
Per-person spending on hospital services, prescription drugs, and long-term care rose 9.1% from 2023 to 2024, nearly twice as fast as the 5.1% state target, according to a new report published Monday ...
110
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 18/05/2026
Life in academia: Working on three grant submissions in addition to clinic today.
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 18/05/2026
Massive fraud uncovered. Dr Oz says 800 hospice providers suspended in California over alleged $1B Medicare fraud scheme www.foxnews.com/media/dr-oz-...
foxnews.com
Dr Oz says 800 hospice providers suspended in California over alleged $1B Medicare fraud scheme
Dr. Oz announces suspension of 800 California hospice providers over alleged Medicare fraud, says Florida and other states also face scrutiny.
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts “Ensitrelvir administered to household contacts of a patient with Covid-19 within 72 hours after symptom onset in the index patient was effective in preventing Covid-19 in the contacts.” www.nejm.org/doi/10.1056/...
nejm.org
Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts | NEJM
Ensitrelvir, an oral inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease, is approved in Japan for the treatment of mild-to-moderate coronavirus disease 2019 ...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
At last, a pill that can prevent COVID after exposure to infected people Drug arrives years after pandemic’s peak, but could still offer protection to vulnerable populations. www.nature.com/articles/d41...
nature.com
At last, a pill that can prevent COVID after exposure to infected people
Drug arrives years after pandemic’s peak, but could still offer protection to vulnerable populations.
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
Training the Next Generation of AI-Enabled Cancer Scientists aacrjournals.org/cancerdiscov...
aacrjournals.org
Training the Next Generation of AI-Enabled Cancer Scientists
Summary:. Despite unprecedented opportunities at the convergence of artificial intelligence (AI) and cancer research, few scientists possess fluency in both domains. We propose a six-principle framewo...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
Checkpoint Breaches: Unexpected Effects of Anti–PD-1 Therapy on the Blood–Brain Barrier aacrjournals.org/cancerdiscov...
aacrjournals.org
Checkpoint Breaches: Unexpected Effects of Anti–PD-1 Therapy on the Blood–Brain Barrier
Summary:. Immune checkpoint inhibitors have revolutionized cancer therapy, and their unintended side effects relate largely to inducing autoimmunity; effects on vascular functions have only rarely bee...
010
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
Tissue-Specific Spatial Regulation of Innate Immune Checkpoints in Cancer aacrjournals.org/cancerdiscov...
aacrjournals.org
Tissue-Specific Spatial Regulation of Innate Immune Checkpoints in Cancer
AbstractNK and innate lymphoid cells (ILC) regulate tissue homeostasis and immune responses by acting as early sensors of cellular stress and tissue dysfunction. Their functions are tightly controlled...
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
VITA-GBM: EPIC-0502-driven HIF1α degradation overcomes bevacizumab resistance and synergizes with TMZ in glioblastoma academic.oup.com/neuro-oncolo...
academic.oup.com
VITA-GBM: EPIC-0502-driven HIF1α degradation overcomes bevacizumab resistance and synergizes with TMZ in glioblastoma
AbstractBackground. Glioblastoma (GBM) is characterized by extensive tissue hypoxia. This hypoxic microenvironment drives chemoresistance and promotes aber
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
Deciphering the tumor microenvironment and role of immunotherapy in diffuse midline glioma: A scoping review academic.oup.com/neuro-oncolo...
academic.oup.com
Deciphering the tumor microenvironment and role of immunotherapy in diffuse midline glioma: A scoping review
Abstract. Diffuse midline glioma, H3 K27-altered, formerly known as diffuse intrinsic pontine glioma, (DIPG/DMG) is the most aggressive form of pediatric b
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts www.science.org/doi/10.1126/...
science.org
Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts
NKG2A checkpoint inhibition promotes lung fibrosis resolution.
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
Ended for futility, BIOMEDE validated prognostic biomarkers as well as informative theranostic biomarkers for future DIPG trials👇 Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial www.nature.com/articles/s41...
nature.com
Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial - Nature Medicine
In a biomarker-driven trial evaluating radiotherapy with erlotinib, everolimus or dasatinib in patients with newly diagnosed diffuse intrinsic pontine glioma, the primary endpoint of overall survival ...
000
Wafik S. El-Deiry, MD, PhD, FACP @weldeiry.bsky.social · 17/05/2026
Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition www.cell.com/cell/fulltex...
cell.com
Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition
Opposing oncogenic and tumor-suppressive forces establish a progenitor-like state that builds a self-reinforcing niche to drive benign-to-malignant transition in pancreatic cancer models. Disruption o...
000