iiinova — where your digital self keeps evolving

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Rebecca Solnit @rebeccasolnit.bsky.social · 30/09/2026

Time for this classic again.

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 23/09/2026

RNF213 M1-ubiquitinates damaged mitochondria to activate pro-inflammatory NF-κB signaling www.biorxiv.org/content/10.64898/20…

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TW @twesq.bsky.social · 20/09/2026

this is fantastic and I learned something new

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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026

ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...

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S.E. Danesti @seedanesti.bsky.social · 18/09/2026

Interviewer: "Where do you see yourself in 5 years?" Me:

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EMBL @embl.org · 15/09/2026

Scientists have determined the highest-resolution protein structure obtained to date. Using advanced X-ray crystallography techniques at EMBL Hamburg's P14 beamline, the team solved the structure of an archaeal protein at an astonishing 0.43 Ångström resolution. www.embl.org/news/science...

embl.org

Every electron counts: most detailed protein structure to date revealed | EMBL

Researchers have used advanced X-ray crystallography methods to determine the structure of an archaeal protein at unprecedented resolution

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 16/09/2026

How do cells remove abnormal glycogen? Led by Matthew Yip, using mouse models, cell engineering & cryo-ET, Felix Randow's group found that RNF213 ubiquitylates aberrant glycogen to trigger autophagy. mrclmb.ac.uk/news-events/articles/h… #LMBResearch

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Old British Telly @oldbritishtelly.co.uk · 15/09/2026

[1975] People Will Always Need Coal - Deliriously kitsch recruitment ad for the implausibly glamorous world of coal-mining. The ad promises a non-stop world of macho glamour fun (Rock'n'Roll! Skiing! Guns! Squash!).

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Agathe Chaigne @agathechaigne.bsky.social · 08/09/2026

Does anyone (ideally local to the Netherlands) have a His-Ub plasmid? High cheese reward.

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Magnus Bauer @kinasekid.bsky.social · 06/09/2026

AlphaFold Server’s ligand menu just got a lot bigger and I almost missed it! You can now add any ligand from the wwPDB Chemical Component Dictionary. Just enter its CCD code 🥳

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Sven Lange @sven-m-lange.bsky.social · 04/09/2026

We’re hiring a Research Technician I at Weill Cornell Medicine in New York City! This is a great opportunity for a recent graduate who’s excited to gain hands-on research experience. Interested, or know someone who might be? Please share! jobs.weill.cornell.edu/NY/job/New-Y... #ResearchJobs

jobs.weill.cornell.edu

Research Technician I

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Stardust 🌏🎬 @stardustbluepr.com · 28/08/2026

Google Dolly Parton. Wait 5 seconds... It's wonderful.

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Jason Song Quinn (Comms Open) @hulkhoquinn.bsky.social · 26/08/2026

Think about Miss Piggy. She lost a best friend and now an ex-lover in matter of 24 hours.

Miss Piggy and Dolly Parton in fancy dresses posing together

photo of Tim Curry surrounded by muppets, smiling for a photo. A quote from curry is added “it didn’t go very well. It didn’t survive the shoot. She felt I wasn’t being faithful to her” it’s him discussing his ill fated affair with miss piggy

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Omar Khan @omaromalleykhan.bsky.social · 26/08/2026

To the question, 'what makes a good life' we don't need deep philosophical reflection The reaction to Dolly Parton's death shows the answer: Treat everyone with respect and dignity, regardless of their background, and try to do as much good as you can (while harming as few people as possible)

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Ian Kelsall @iankelsall.bsky.social · 18/08/2026

Congratulations @prithadg.bsky.social ! This was a fun project that allowed me to mess about on computers for a little bit, learning how to design de novo protein binders.

static.klipy.com

computer monkey

Alt: A monkey wearing glasses sits next to a plate of fruit and vegetables and types away furiously at a computer keyboard.

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The EMBO Journal @embojournal.org · 18/08/2026

Why is human p97 ATPase less efficient than yeast Cdc48 in unfolding its protein substrates? @kulathu.bsky.social et al show how cofactors like FAF2 facilitate efficient unfolding by the human enzyme, & design artificial mini-proteins able to potently activate p97 link.springer.com/article/10.1...

link.springer.com

FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators - The EMBO Journal

VCP/p97 is an AAA+ ATPase that, together with its cofactors UFD1-NPL4 (p97-UN), unfolds ubiquitylated substrates to maintain cellular homeostasis. The human p97-UN complex associates with additional c...

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Penny Homer @socialsoprano.bsky.social · 19/07/2026

Ophelia, 1852, John Everett Millais

Lionel Messi lying on the ground with his head in his hands

Sir John Everett Millais's famous Ophelia painting

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ArtButMakeItSports @artbutmakeitsports.bsky.social · 15/07/2026

The Battle of the Peasants, by M.D. Hout, 17th c

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ArtButMakeItSports @artbutmakeitsports.bsky.social · 14/07/2026

At the Moulin Rouge, The Dance, by Henri de Toulouse-Lautrec, 1890

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Magnus Bauer @kinasekid.bsky.social · 14/07/2026

Can we program a kinase like a switch? Inspired by natural autoinhibitory complexes, we designed miniproteins against active- and inactive-like conformations of Focal Adhesion Kinase. Depending on the targeted state, the resulting binders either activated or inhibited the kinase.

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John Coulson @northerneater.bsky.social · 03/07/2026

During the last #WorldCup, I randomly found my long lost Mexico '86 #Panini sticker album. And with England at the Azteca next, I thought you might like to see it. It was the first World Cup I can remember, and I can hardly believe it was 40 years ago. Let's hop into the DeLorean, shall we?... 🧵

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Scandifriend @scandifriend.bsky.social · 15/06/2026

Don Quixote, Pedro Almodavar, Julio Iglesias, Francisco Goya, can you hear me? Your boys just took one hell of a drawing.

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Bryan @elwick70.bsky.social · 12/06/2026

Yorkshire, indeed the world, has lost some of its colour today. Garrowby Hill, a Yorkshire landscape by David Hockney, 1998. So long, David.

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Dan Hon @danhon.com · 12/06/2026

OCEANIA HAS ALWAYS BEEN VERY CLOSE TO A DEAL WITH EURASIA

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fiveankles.bsky.social @fiveankles.bsky.social · 11/06/2026

Everything you can expect from the World Cup Opening Ceremony. Music from #Uppbeat (free for Creators!): uppbeat.io/t/benjamin-b... License code: JVYDUZB9GVWKNVC5

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Matt McFarland @emseefarlandee.bsky.social · 10/06/2026

Delighted that this is now out in its final form! 🥳 It's a fun story about an EF hand that doesn't bind Ca2+, but instead works as a ubiquitin-binding domain. Huge thanks to the rest of YK lab, the @mrcppu.bsky.social, and our collaborators (@sebastianglatt.bsky.social)!

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Son of Bengt @sonofbengt.bsky.social · 10/06/2026

"Let's say this Twinkie represents the outright racists in the UK when that BNP list got leaked in 2008. According to this morning's sample, it'll be a Twinkie....35 feet long and weighing approximately 600 lbs"

Egon Spengler explaining about ghost activities using a Twinkie for scale

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Derek Lowe @dereklowe.bsky.social · 10/06/2026

A fellow of the Royal Society slashed funding for disease prevention, leading directly to the deaths of uncounted children. He promotes white supremacy and is actively encouraging racist violence in the UK. But he's Elon Musk, a billionaire. So the Royal Society does nothing. @royalsociety.org

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Stephen Curry @scurry.bsky.social · 10/06/2026

Violence on the streets of the U.K. incited and enabled by Elon Musk, a fellow of the @royalsociety.org. When will our national academy stand up for the values it claims to espouse?

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Colm Murphy @colmpm.bsky.social · 10/06/2026

I have to say, listening to the Today programme dedicate an entire (context free) section about whether migrants are more likely to be convicted criminals *the morning after* hundreds of non-migrants of my own ethnicity committed a pogrom is blood boiling.

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Doug Mack @douglasmack.bsky.social · 08/06/2026

Just need everyone to know that the Belgium men's soccer team has new jerseys based on the art of Rene Magritte and this is the official photo shoot

Soccer player wearing fedora and with a green apple floating in front of his face, mimicking the Magritte painting "The Son of Man." The soccer player is wearing a jersey with a pattern of pink and blue stripes with half-visible spheres.

Soccer player biting an apple. The soccer player is wearing a jersey with a pattern of pink and blue stripes with half-visible spheres.

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Ian Kelsall @iankelsall.bsky.social · 05/06/2026

This just gets worse, and worse, and worse.

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Susan DuBose @houseofbast777.bsky.social · 04/06/2026

'Loot from the Rainbow' Arthur Ferrier, Tattler Magazine, 1928 Scottish artist, illustrator & cartoonist #Pride2026

Image is of a glamorous woman draped in a rainbow colored, very long scarf

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Matt McFarland @emseefarlandee.bsky.social · 02/06/2026

Mammalian gene naming conventions and the potential for this kind of mistaken identity have long been a pet hate of mine. There will definitely be other examples of this out there.

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Marios Stavridis @mstavridis.bsky.social · 29/05/2026

Amazing lab, doing fantastic work. Highly recommend. And it's in Dundee, which is obviously a bonus. 😜

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robertomunita.bsky.social @robertomunita.bsky.social · 29/04/2026

1/ Sharing my article in TIBS: "Science is always unfinished: rethinking the demand for complete stories." The cost of that demand: delayed dissemination, cherry-picked data, and an endless "one more experiment" loop. authors.elsevier.com/a/1n0XU3S6Gf...

authors.elsevier.com

Please wait whilst we redirect you

All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.

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TeselaGen Biotechnology @teselagen.bsky.social · 27/05/2026

The known protein universe just got a lot bigger. A newly released artificial-intelligence tool has generated an atlas of more than one billion predicted protein structures and billions more protein sequences. #AI #biotech

nature.com

Move over, AlphaFold: open source model predicts shape of 1 billion proteins

The new open-source atlas, generated by an AI tool called ESMFold2, vastly increases the known protein universe.

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Ste Jormur @stejormur.bsky.social · 26/05/2026

The arc of history is long, but it bends towards the Vatican including a LinkedIn clip art of a woman in a hijab under "The true human being"

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Reese Richardson @reeserichardson.bsky.social · 21/05/2026

@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...

Apparent manipulation in the antibody verification data in Thermo Fisher's online catalog

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Derek Lowe @dereklowe.bsky.social · 21/05/2026

By this point we need to make a list of what ubiquitin doesn’t do:

science.org

Ubiquitin Rides Again

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Rachel O'Dea @rnidhea.bsky.social · 21/05/2026

10 days left to register for the 2026 EMBO ubiquitin conference! Join us in coastal Puglia, for a jam packed schedule on all things ubiquitin (and friends). Fantastic line up of speakers and an impressive amount of opportunities for ECRs and networking. meetings.embo.org/event/26-ubi...

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Aanchal Mishra @origichals.bsky.social · 21/05/2026

You know the most destructive molecule for my experiments is Air? ITC thermogram shifts? Bubble. Gel refuses to run properly? Bubble. Crystallization ruined? Bubble. Mysterious signal artifacts? Also bubble. My troubleshooting career = fighting microscopic air pockets with a pipette tip. #origichals

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Eric Ravenscraft @lordravenscraft.bsky.social · 14/05/2026

still not quite over the fact that i watched 15 year olds get sued for millions of dollars for downloading twelve songs and now we all have to accept AI slop because every tech company in the known universe decided that IP laws don't exist now that they're inconvenient for them

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Ian Kelsall @iankelsall.bsky.social · 13/05/2026

Excited to be in Edinburgh for the next few days at the pediEDI 2006 conference on Protein Evolution, Design & Informatics, organised by @biochemsoc.bsky.social. Looking forward to learning lots! #BiochemEvent

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Angri Bundel @anibundel.com · 11/05/2026

We lost Douglas Adams 25 years ago today. This has made a lot of people very sad and has been widely regarded as a bad move.

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Todd Douglas @apoptoddic.bsky.social · 30/04/2026

Our paper is now out in @natcellbio.nature.com! @craigmcrews.bsky.social www.nature.com/articles/s41... We identify a new regulator of the quality control system that protects one of nature's most important molecular machines: the ribosome. QC failure → unmitigated metabolic stress & cell death.

nature.com

The atypical E3 ligase HOIL-1 safeguards the ribosome during cellular stress - Nature Cell Biology

Douglas et al. study the E3 ligase HOIL-1, mutated in patients with a type of myopathy. Mutant HOIL-1 influences the sensitivity to disulfidptosis initiated by ZAKα–ATF4 in glucose starvation and inte...

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