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MRC PPU

@mrcppu.bsky.social
111 followers 74 following 63 posts

The MRC Protein Phosphorylation & Ubiquitylation Unit is a world leader in finding the causes of neurodegeneration, cancer, hypertension & immune disorders www.ppu.mrc.ac.uk

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MRC PPU @mrcppu.bsky.social · 28/09/2026
Esther Sammler receives the 2026 Tom Isaacs Award www.ppu.mrc.ac.uk/news/esther-...
ppu.mrc.ac.uk
Esther Sammler receives the 2026 Tom Isaacs Award | MRC PPU
Dr Esther Sammler, Group Leader in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) at the University of Dundee and Honorary Consultant Neurologist at NHS Tayside, has received the pr...
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MRC PPU @mrcppu.bsky.social · 07/09/2026
Targeted degradation of α-synuclein as a therapeutic approach to suppress pathological aggregation in #Parkinsons disease www.ppu.mrc.ac.uk/news/targete...
ppu.mrc.ac.uk
Targeted degradation of α-synuclein as a therapeutic approach to suppress pathological aggregation in Parkinson’s disease | MRC PPU
A new study led by the Sapkota Lab, in collaboration with Johnson & Johnson Neuroscience Discovery, has demonstrated that targeted protein degradation can selectively eliminate endogenous α-synuclein ...
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MRC PPU @mrcppu.bsky.social · 07/09/2026
Best of luck today to Ricardo Moreno Ballesteros of the Virdee lab, defending his PhD thesis 'Biorthogonal Proximity Inducer (BPI) Platform: Where Induced Proximity meets Genetic Code Expansion'
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MRC PPU @mrcppu.bsky.social · 14/08/2026
Join us at Dundee’s MRC PPU!! We are recruiting for an exceptional individual to join us as a Postdoctoral Researcher in #massspectrometry and #proteomics to apply next-generation #OrganelleProteomics to uncover the molecular basis of #Parkinsons #neurodegeneration www.ppu.mrc.ac.uk/careers/recr...
ppu.mrc.ac.uk
Postdoctoral Researcher — Mass Spectrometry & Proteomics | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
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MRC PPU @mrcppu.bsky.social · 10/08/2026
High-fidelity human endothelial cell models for mechanistic and therapeutic investigations www.ppu.mrc.ac.uk/news/high-fi... @ralitsamadsen.bsky.social
ppu.mrc.ac.uk
High-fidelity human endothelial cell models for mechanistic and therapeutic investigations | MRC PPU
Two PhD students from the Madsen Lab at the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU), Oliwia Mruk and Alexandra Musk, have developed optimised workflows for generating arterial- a...
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MRC PPU @mrcppu.bsky.social · 05/08/2026
Dr Anna Pérez i Ràfols receives prestigious Wellcome Early-Career Award to investigate how cells survive stress www.ppu.mrc.ac.uk/news/dr-anna... @wellcometrust.bsky.social @kulathu.bsky.social
ppu.mrc.ac.uk
Dr Anna Pérez i Ràfols receives prestigious Wellcome Early-Career Award to investigate how cells survive stress | MRC PPU
Dr Anna Pérez i Ràfols has received a prestigious five-year Wellcome Early-Career Award to establish an ambitious research programme investigating the molecular signals that protect cells under stress...
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MRC PPU @mrcppu.bsky.social · 04/08/2026
Join us! We’re hiring 2 Research Technicians to help accelerate #Parkinsons disease therapeutics through #proteomics, organelle biology & in vivo research with global academic & industry partners www.ppu.mrc.ac.uk/careers/recr... #ResearchJobs #Dundee #neurodegeneration #biochemistry #CellBiology
ppu.mrc.ac.uk
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Raja Nirujogi @nirujogi.bsky.social · 20/07/2026
Biennial International LRRK2 meeting 2026 just kicked off in the beautiful city of Dundee @biochemsoc.bsky.social @lrrk2central.bsky.social @asapresearch.parkinsonsroadmap.org. Welcome to Dundee!!
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Biochemical Society @biochemsoc.bsky.social · 21/07/2026
Session One of International LRRK2 has kicked off today in Dundee with Dario Alessi talking about New Mechanistic Insights into LRRK2 signalling #BiochemEvent
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Mahima Swamy @mahimaswamy.bsky.social · 09/07/2026
📣job alert! I’m urgently looking for a postdoc with immunology expertise #flowcytometry #Bcells to join my lab for 2.5 years asap! Position @mrcppu.bsky.social in Dundee, Scotland. Please read more at link: www.ppu.mrc.ac.uk/careers/recr...
Sunrise on the beach at Dundee
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European Association for the Study of Diabetes @easdnews.bsky.social · 16/07/2026
🏆 We are honoured to announce Prof. Kei Sakamoto (@ucph.bsky.social) as the recipient of the #EASD - Novo Nordisk Foundation #Diabetes Prize for Excellence 2026! Learn more 👉 www.easd.org/prizes/easd-... We look forward to his prize lecture & honouring him at #EASD2026 in Milan👏
Social media announcement graphic for the EASD Annual Meeting 2026, taking place in Milan, Italy from 28 September to 02 October 2026. The graphic announces Prof. Kei Sakamoto as the recipient of the EASD-Novo Nordisk Foundation Diabetes Prize for Excellence. A circular headshot of Prof. Sakamoto - a man with dark hair wearing a light blue shirt, smiling - is displayed on the right side. The EASD 2026 Milan branding appears throughout, with a stylised Milan skyline illustration in navy blue on the right. The website address easd.org is shown in the bottom right corner.
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MRC PPU @mrcppu.bsky.social · 14/07/2026
The MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) launches Ubiquigent Plus to accelerate ubiquitin research worldwide www.ppu.mrc.ac.uk/news/mrc-pro...
ppu.mrc.ac.uk
The MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) launches Ubiquigent Plus to accelerate ubiquitin research worldwide | MRC PPU
The MRC PPU is the only research institute in the world dedicated to the study of the two post-translational modifications used most frequently to regulate protein functions in living cells. With over...
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MRC PPU @mrcppu.bsky.social · 08/07/2026
Join us! Postdoctoral Researcher position available, working with Ian Ganley and Miratul Muqit www.ppu.mrc.ac.uk/careers/recr... @asapresearch.parkinsonsroadmap.org #Parkinsons
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MRC PPU @mrcppu.bsky.social · 29/06/2026
🎉 Excited to share our #MovementDisorders Viewpoint on challenges in LRRK2-targeted therapies for #Parkinsons. We outline key scientific and clinical hurdles and future directions. Thanks to all collaborators doi.org/10.1002/mds.... #LRRK2 #DrugDiscovery #Neurology @movedisorder.bsky.social
doi.org
Addressing the Challenges of Translating LRRK2 Biology into Disease‐Modifying Therapies: The LRRK2 Investigative Therapeutics Exchange Initiative
Click on the article title to read more.
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UK Research and Innovation @ukri.org · 23/06/2026
We're excited to announce two new AI research labs that will develop next generation AI systems in Britain. With up to £60m #EPSRC investment, the labs will rethink how AI works, how it learns and how it can be made more open, efficient and useful for the UK. More👉 www.ukri.org/news/ukri-la...
Screenshot of web news story. Blue text on white background reads: UKRI launches two AI research labs to stay ahead in global race. Below is an image of cloud data centres.
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MRC PPU @mrcppu.bsky.social · 22/06/2026
A new therapeutic strategy for MTDPS13 www.ppu.mrc.ac.uk/news/new-the...
ppu.mrc.ac.uk
A new therapeutic strategy for MTDPS13 | MRC PPU
Mitochondrial DNA Depletion Syndrome 13 (MTDPS13) is a rare and devastating mitochondrial disease that causes the loss of healthy mitochondria, leading to severe energy deficiency throughout the body ...
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Matt McFarland @emseefarlandee.bsky.social · 10/06/2026
Delighted that this is now out in its final form! 🥳 It's a fun story about an EF hand that doesn't bind Ca2+, but instead works as a ubiquitin-binding domain. Huge thanks to the rest of YK lab, the @mrcppu.bsky.social, and our collaborators (@sebastianglatt.bsky.social)!
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MRC PPU @mrcppu.bsky.social · 25/05/2026
Biallelic #LRRK2 loss-of-function is associated with a Mendelian form of interstitial lung disease characterized by alveolar dysfunction & lung fibrosis - an important role for LRRK2 kinase signaling in lysosomal trafficking/exocytosis & human surfactant homeostasis www.medrxiv.org/content/10.6...
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MRC PPU @mrcppu.bsky.social · 15/05/2026
Join us! Postdoctoral Researcher positions available in Muqit lab www.ppu.mrc.ac.uk/careers/recr... #CRISPR #PINK1 #Parkinsons
ppu.mrc.ac.uk
Postdoctoral Research Assistant | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
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The Royal Society @royalsociety.org · 15/05/2026
Mary Lyon FRS was born #OnThisDay in 1925. Lyon was the discoverer of X-chromosome inactivation, which the genetic process that leads to coloration like tortoiseshell cats. Read more about her discoveries in a @royalsocietypublishing.org biographical memoir. #WomenInSTEM bit.ly/4wutdqf
A tortoiseshell cat with green eyes sitting on a rug against a white wall.A black and white photograph portrait of a woman with glasses. She's wearing a dark coat and a necklace is visible at her collar.
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 13/05/2026
Got a science shaped hole in your Monday evening? Why not pop along to #PintofScience! Rosie Street-Jeakings & Christopher Bailey are both talking about #malaria research. Get your tickets at the link! pintofscience.co.uk/event/drugs-...
pintofscience.co.uk
Drugs and Bugs: The Fight for Global Health
Why does disease only target certain people? How do we make new treatments for that disease? Does your postcode alter the treatment you get? These are all …
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MRC PPU @mrcppu.bsky.social · 06/05/2026
Postdocs available in #Parkinsons research studying LRRK2, GBA1 & α-synuclein biology using organelle proteomics, single-cell MS, translational neuroscience, next-gen PTM workflows, cutting-edge infrastructure, strong mentorship & international collaborations www.ppu.mrc.ac.uk/careers/recr...
ppu.mrc.ac.uk
Postdoctoral Researcher | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
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MRC PPU @mrcppu.bsky.social · 06/05/2026
MRC PPU researchers receive major funding to explore new frontiers in Parkinson’s disease www.ppu.mrc.ac.uk/news/mrc-ppu... @asapresearch.parkinsonsroadmap.org #Parkinsons
ppu.mrc.ac.uk
MRC PPU researchers receive major funding to explore new frontiers in Parkinson’s disease | MRC PPU
Researchers at the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) at the University of Dundee have been awarded a series of major international research grants totalling $18 million fro...
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MRC PPU @mrcppu.bsky.social · 06/05/2026
Congratulations Prosenjit and Odetta 🎉🎉 ASAP Discovery Fellowships awarded to MRC PPU researchers www.ppu.mrc.ac.uk/news/asap-di... @asapresearch.parkinsonsroadmap.org @prosenjit.bsky.social @odettaantico.bsky.social #Parkinsons
Prosenjit Pal (left) and Odetta Antico (right)
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Prosenjit Pal @prosenjit.bsky.social · 05/05/2026
As a Guest Editor for JoVE Journal, we are organizing a Topical Collection titled “Cellular Pathways in Neurodegenerative Disorders: Trafficking, Organelle Dynamics, and Metabolism.” Interested in contributing? Please submit an abstract here: www.jove.com/methods-coll...
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MRC PPU @mrcppu.bsky.social · 30/04/2026
Join us! TENOVUS funded 3-year PhD studentship available in the De Cesare lab www.dundee.ac.uk/phds/opportu... #ubiquitylation #PhD 🎓
dundee.ac.uk
Deciphering the role of UBE2Q1 and non-canonical ubiquitylation in tumorigenesis | University of Dundee, UK
A PhD project at the University of Dundee
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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 28/04/2026
📢 Unraveling Parkinson’s. Advancing Precision Medicine. New CRN grants in partnership with The Michael J. Fox Foundation for Parkinson’s Research bring together 32 global teams to map the biology of #ParkinsonsDisease and build tools to accelerate discovery. 🔗 Learn more: bit.ly/4ugkfes
Graphic with a light purple gradient background featuring the headline: “Unraveling Parkinson’s. Advancing Precision Medicine.” Subhead reads: “Mapping the biological blueprint of Parkinson’s disease and building global research resources.” Along the bottom are logos for ASAP (Aligning Science Across Parkinson’s), the Collaborative Research Network (CRN), and The Michael J. Fox Foundation for Parkinson’s Research.
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MRC PPU @mrcppu.bsky.social · 24/04/2026
Congratulations to MRC PPU Director Dario Alessi, elected as a member of the American Academy of Arts & Sciences www.amacad.org/new-members-...
amacad.org
New Academy Members
Elected in 2026
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MRC PPU @mrcppu.bsky.social · 21/04/2026
Unlocking Cellular Control: Kai Gallant Awarded Prestigious MSCA Fellowship www.ppu.mrc.ac.uk/news/unlocki... @e3chembio.bsky.social @gallantkai.bsky.social
ppu.mrc.ac.uk
Unlocking Cellular Control: Kai Gallant Awarded Prestigious MSCA Fellowship | MRC PPU
We are thrilled to announce that Kai Gallant, a postdoctoral fellow in the lab of Professor Satpal Virdee, has been awarded the Marie Skłodowska-Curie Actions (MSCA) Postdoctoral Fellowship. This high...
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Lorraine Reese @lorraine-reese.bsky.social · 15/04/2026
Super earlybird - £100 off! Book by 20 April 2026 for the #LRRK2 meeting, where scientists and clinicians share advances in Parkinson’s biology and therapies 🧪: bit.ly/LRRK2-26
Biochemical Society scientific meeting: Biennial International LRRK2 meeting 2026. Abstract submission now open. Super earlybird deadline 20 April 2026. Includes Biochemical Society logo, image of delegates networking and event logo.
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MRC PPU @mrcppu.bsky.social · 17/04/2026
New Study from the Sapkota Lab the Role of Protein Context in Targeted Protein Degradation www.ppu.mrc.ac.uk/news/new-stu... @gpsapkota.bsky.social @lglennie.bsky.social
ppu.mrc.ac.uk
New Study from the Sapkota Lab the Role of Protein Context in Targeted Protein Degradation | MRC PPU
A new study led by the Sapkota Lab in collaboration with Harvard’s Woo lab is shedding light on how an emerging class of medicines, designed to eliminate specific harmful proteins in cells, may have b...
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Biochemical Society @biochemsoc.bsky.social · 14/04/2026
From redefining our understanding of ubiquitin regulation to developing bespoke reagents and tools, the Biochemical Society Award for Sustained Excellence is presented to Elton Zeqiraj Elton's work showcases long-term commitment to translating mechanistic insights into biomedical innovation.
Award banner for the Biochemical Society 2027 recognizing Professor Elton Zeqiraj from University of Leeds for sustained excellence.
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Biochemical Society @biochemsoc.bsky.social · 14/04/2026
Congratulations to Tom Deegan who receives the Colworth Medal in 2027! Pioneering work from the Deegan Lab has redefined our understanding of eukaryotic DNA replication and provided conceptual and technical frameworks that continue to drive new discoveries across molecular biology.
Dr Tom Deegan from University of Edinburgh awarded The Colworth Medal by The Biochemical Society 2027 Awards.
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MRC PPU @mrcppu.bsky.social · 10/04/2026
World #Parkinsons Day 2026: Celebrating a powerful partnership between research and lived experience www.ppu.mrc.ac.uk/news/world-p...
ppu.mrc.ac.uk
World Parkinson’s Day 2026: Celebrating a powerful partnership between research and lived experience | MRC PPU
Since 2017, DRIG has brought together people with Parkinson’s, carers, clinicians and researchers, helping to improve research culture and ensuring that lived experience plays a meaningful role in shaping and sharing research.
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MRC PPU @mrcppu.bsky.social · 08/04/2026
www.movementdisorders.org/MDS/About/MD... @movedisorder.bsky.social
movementdisorders.org
MDS-ES Focused Workshop
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MRC PPU @mrcppu.bsky.social · 02/04/2026
Fantastic opportunity for an early-stage researcher wishing to gain valuable experience in state-of-the-art translational research in the #Parkinsons field www.ppu.mrc.ac.uk/careers/recr...
ppu.mrc.ac.uk
Research Technician | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
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MRC PPU @mrcppu.bsky.social · 02/04/2026
Empowering dementia conversations with Black African and Caribbean communities in partnership with UCL www.ppu.mrc.ac.uk/news/empower...
ppu.mrc.ac.uk
Empowering dementia conversations with Black African and Caribbean communities in partnership with UCL | MRC PPU
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MRC PPU @mrcppu.bsky.social · 31/03/2026
Join us! Postdoctoral Researcher position available in the Ganley Lab www.ppu.mrc.ac.uk/careers/recr...
ppu.mrc.ac.uk
Postdoctoral Researcher | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
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IRB Barcelona @irbbarcelona.org · 23/03/2026
Missed the #Glycogen Symposium – Honouring the Legacy of #JoanGuinovart? You can now watch the full session and revisit the insights and tributes to an exceptional scientist. ▶️ www.youtube.com/live/CQBl90m... #Tribute #FEBS #IUBMB @iubmb.bsky.social
youtube.com
Glycogen Symposium: Honouring the legacy of Joan Guinovart
YouTube video by IRB Barcelona
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MRC PPU @mrcppu.bsky.social · 20/03/2026
Congratulations Aniketh 🎉 Aniketh Bishnu wins poster prize at STEM for Britain 2026 www.ppu.mrc.ac.uk/news/aniketh...
ppu.mrc.ac.uk
Aniketh Bishnu wins poster prize at STEM for Britain 2026 | MRC PPU
Congratulations to Dr Aniketh Bishnu, a postdoctoral researcher in the Ganley Lab, who was awarded the Silver Prize for his poster presentation at the Houses of Parliament in London. He was a finalist...
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MRC PPU @mrcppu.bsky.social · 20/03/2026
Scientists Discover a Unique Viral Trap within the Human Immune System www.ppu.mrc.ac.uk/news/scienti...
ppu.mrc.ac.uk
Scientists Discover a Unique Viral Trap within the Human Immune System | MRC PPU
Researchers at the MRC Protein Phosphorylation Unit and the Centre for Virus Research at the University of Glasgow have uncovered a previously unknown antiviral mechanism that functions like a molecul...
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MRC PPU @mrcppu.bsky.social · 20/03/2026
Miratul Muqit: leading an alliance to decode Parkinson's disease - The Lancet Neurology www.thelancet.com/journals/lan...
thelancet.com
Miratul Muqit: leading an alliance to decode Parkinson's disease
As the inaugural Director of the new Parkinson's Research Centre, funded by the UK Dementia Research Institute and Parkinson's UK, Professor Miratul Muqit (University of Dundee, UK) hopes to untangle ...
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Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 16/03/2026
For #BrainAwarenessWeek, we’re highlighting the ASAP CRN Cloud, helping researchers accelerate #Parkinsons research through open data sharing. It includes: 🧠 1,810 samples 🔬 Contributions from 12 CRN teams 🌍 22 public datasets Explore the CRN Cloud: parkinsonsroadmap.org/crn-cloud
Purple-to-blue gradient graphic with the ASAP and CRN Cloud logos. Large text reads "Explore the CRN Cloud," followed by "A data-sharing and analysis platform available to the entire research community." On the right is a stylized brain illustration made of interconnected nodes and lines.
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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 10/03/2026
@lancasterlab.bsky.social, Joint Head of the LMB’s Cell Biology Division (@cellbiol-mrclmb.bsky.social), was recognised in the 2026 Suffrage Science Awards for her work on brain organoids 🧠 Congratulations to Madeline and the other 2026 awardees! Read more: mrclmb.ac.uk/news-events/... #LMBNews
Madeline Lancaster
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Ian Kelsall @iankelsall.bsky.social · 01/03/2026
🚨⚠️ New Preprint Alert! ⚠️ 🚨 www.biorxiv.org/content/10.6... Screening p97 cofactors, @prithadg.bsky.social identified FAF2 as the strongest activator of the p97-UFD1-NPL4 complex. Leveraging her mechanistic descoveries, we designed 𝘥𝘦 𝘯𝘰𝘷𝘰 binders that could also enhance p97 substrate unfolding.
Image of FAF2's predicted helical domain interacting with the UFD1 UT3 domain. Next to this are similar images showing the predicted binding of de novo designed protein binders to the same region. Above is a sequence alignment indicating the key residues involved in the interaction.
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UK Dementia Research Institute @ukdri.ac.uk · 24/02/2026
Recently, UK DRI’s Prof Miratul Muqit, Parkinson’s Research Centre Director, joined partners from @parkinsons.org.uk in Parliament He spoke with policymakers about the importance of research inclusion & showcased how he would embed inclusion at the co-founded Centre www.ukdri.ac.uk/news-and-eve...
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MRC PPU @mrcppu.bsky.social · 24/02/2026
Join us! Postdoctoral position available in Virdee lab www.ppu.mrc.ac.uk/careers/recr...
ppu.mrc.ac.uk
Postdoctoral Research Assistant | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
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The Courier UK @thecourier.co.uk · 19/02/2026
“When I first got fitted with the pump I spent the day playing music."
dlvr.it
Broughty Ferry woman first in Tayside to receive ‘life-changing’ Parkinson’s drug
“When I first got fitted with the pump I spent the day playing music."
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MRC PPU @mrcppu.bsky.social · 03/02/2026
Join us! Research Technician position available with Virginia De Cesare www.ppu.mrc.ac.uk/careers/recr...
ppu.mrc.ac.uk
Research Technician | MRC PPU
We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helpi...
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Drug Discovery Unit, University of Dundee @ddu-dundee.bsky.social · 30/01/2026
Want to see what we do up close? Sign up for the tour and networking event with us and #biodundee. See the link for details and tickets! #DDUat20 www.eventbrite.co.uk/e/drug-disco...
eventbrite.co.uk
Drug Discovery Unit Tour and Networking
BioDundee is delighted to kick of the year of celebrations for #DDUat20 with Networking and a guided tour of the Drug Discovery Unit.
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