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The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Developed by and for academics, OpenScholar aims to improve searches of the ballooning scientific literature

Combining generative AI and one round of wet lab evolution generates high-affinity RNA aptamers.

A biophysical model uses knockdown or overexpression data to infer splicing factor activity.

Nature Reviews Molecular Cell Biology, Published online: 09 October 2025; doi:10.1038/s41580-025-00913-5Latin American–Caribbean single-cell genomics initiatives are generating inclusive AI-ready data for precision medicine, and empowering the region’s scientists to become researcher leaders.

Nature Reviews Molecular Cell Biology, Published online: 13 October 2025; doi:10.1038/s41580-025-00896-3Nanopore RNA sequencing is a potent technology for the detection of RNA modifications. Nanopore modification-aware base-calling models have been recently developed, and this Progress article discusses their limitations, including modification cross-reactivities, variability in false positive rates and modification-calling threshold choices.

Nature Reviews Molecular Cell Biology, Published online: 03 November 2025; doi:10.1038/s41580-025-00920-6The discovery of noncanonical short open reading frames that produce functional microproteins upended our perception of large parts of our genome as ‘noncoding’.