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George Birchenough

@gobletcellguy.bsky.social
817 followers 1.2K following 47 posts

Updates from the Birchenough Lab, one of the Mucin Biology Groups based at the University of Gothenburg. All things goblet cell, mucus and mucin. Check us out: www.birchenoughlab.org www.medkem.gu.se/mucinbiology

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Reposted by George Birchenough
Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 15/05/2025
Microbiota colonising the new born colon prime goblet cells producing the gut-protective mucus 📷 Åsa Johansson et al @gobletcellguy.bsky.social University of Gothenburg in @jem.org ➡️ bpod.org.uk/archive/2025...
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George Birchenough @gobletcellguy.bsky.social · 05/05/2025
Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎
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Lars Vereecke @larsvereecke.bsky.social · 24/03/2025
Abstract deadline for #GGIG2025 is approaching fast! Don’t miss your chance to share your research at the 5th Ghent Gut Inflammation Group Meeting! 🧬🦠 www.vibconferences.be/events/5th-g...
vibconferences.be
5th Ghent Gut Inflammation Group Meeting
15-16 May 2025, Ghent, Belgium Host-microbiota interactions in health and disease
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Reposted by George Birchenough
Mucosal Immunology @mucosalimmunol.bsky.social · 28/03/2025
Which cells use Myd88 to control Segmented Filamentous Bacteria colonization? Here work explores the hematopoietic MyD88/IL-22 axis during SFB growth. www.mucosalimmunology.org/article/S193...
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George Birchenough @gobletcellguy.bsky.social · 22/03/2025
My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...
biorxiv.org
Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence fact...
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George Birchenough @gobletcellguy.bsky.social · 20/03/2025
Nice discussion around the ongoing #glycoRNA debate, check out the comments
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Lars Vereecke @larsvereecke.bsky.social · 11/03/2025
In our lates review, we explore new insights into the gut-joint axis, a connection is not absolute. A causal role for the microbiota is context-dependent, and arthritis can also arise independently through sterile mechanisms: authors.elsevier.com/a/1kkn55Eb0R... #GutJointAxis
authors.elsevier.com
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George Birchenough @gobletcellguy.bsky.social · 26/02/2025
Say what now?!
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Reposted by George Birchenough
Prof. Ruth Ley FRS @microbiome.bsky.social · 25/02/2025
So excited to share this latest work by @kelseyhuus.bsky.social !!! She shows that flagellin in the human gut affects whether or not people develop fever in response to vaccine, and the amount of flagellin reflects diet
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Daniel Bojar @dbojar.bsky.social · 18/02/2025
glycowork v1.5 is now released! We're excited to see the cool things you'll be doing with it:-) Lots of new & improved functionality, check out the Release notes for the full change log:
github.com
Release v1.5.0 · BojarLab/glycowork
Changelog [1.5.0] Added ✨ Added type hints to all functions (e6721a1) Added CodeCov shield to track PyTest test code coverage (23d6456) Added more PyTest unit tests (e.g., 0c94995, 23d6456, 5a99d6...
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Christian Diener @cdiener.com · 18/02/2025
Happy to announce that MEDI, our method to quantify dietary intake through metagenomics is out now. 🧬 🧪🧫🦠 www.nature.com/articles/s42... #metagenomics #microbiome #microbiomesky So what is MEDI? A combination of two things:
nature.com
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
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Reposted by George Birchenough
Olivia Coleman @ocoleman.bsky.social · 17/02/2025
For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social #mucusmatters
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Reposted by George Birchenough
Hall Lab @halllab.bsky.social · 11/01/2025
1/ 🚨 New preprint alert! 🚨 We’re thrilled to share our latest work exploring microbiome & genomic #Bifidobacterium co-evolutionary & functional signatures across diverse animal hosts. This has been a long time coming, & huge credit to Magda for her incredible hard work as first author! 🐾✨👇
doi.org
Host-specific microbiome and genomic signatures in Bifidobacterium reveal co-evolutionary and functional adaptations across diverse animal hosts
Animal hosts harbour divergent microbiota, including various Bifidobacterium species and strains, yet their evolutionary relationships, and functional adaptions remain understudied. By integrating tax...
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George Birchenough @gobletcellguy.bsky.social · 17/02/2025
This was a fun study from Scott Hultgrens lab that we contributed to, led by Philippe Azimzadeh, looking at #UPEC interactions with colonic #mucus: www.science.org/doi/10.1126/...
science.org
Mechanisms of uropathogenic E. coli mucosal association in the gastrointestinal tract
Inverse regulation of flagella and type 1 pili facilitates access to colon mucus by uropathogenic E. coli.
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Reposted by George Birchenough
Lucy Crouch @lucyicm.bsky.social · 31/01/2025
New paper out today from the lab on Akkermansia muciniphila 🦠and how it breaks down host glycans! Very proud of my group, especially @cassiebakshani.bsky.social who did an amazing job. @naturemicrobiol.bsky.social www.nature.com/articles/s41...
nature.com
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology
Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, wh...
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Maryse Berkhout @maryseberkhout.bsky.social · 12/02/2025
#microsky
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 13/02/2025
Discovery of a new Cu-dependent cellulose degrading enzyme for biomass conversion #glycotime (trying to overlook the extraneous proton, see if you can find it) www.nature.com/articles/s41...
nature.com
A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion - Nature
A metalloenzyme capable of oxidatively cleaving cellulose, found in a microbial community specialized in lignocellulose degradation, could enable sustainable biofuel production.
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Kathryn Knoop, PhD @kknoop.bsky.social · 14/02/2025
Don’t miss #ASRI2025 in St. Paul Minnesota May 17-21. Check out fantastic talks on the Maternal, Fetal, and Neonatal Immunology and submit your abstract by 2/15! theasri.org/Abstracts-Po...
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Reposted by George Birchenough
Natalia Torow @ntorow.bsky.social · 11/02/2025
Still time to submit late breaking abstract to this fantastic meeting: www.perinatal-immunity.de/en/symposium...
perinatal-immunity.de
International Symposium on Perinatal and Early Life Immunity | perinatal immunity immunology TRR 359 PILOT
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ex-Lethality Jane @lethalityjane.bsky.social · 15/02/2025
The measles outbreak in Texas is reminding me of the public letter Roald Dahl wrote about losing his daughter to measles in 1962, just before the vaccine was publicly available.
Excerpt from a public letter Roald Dahl wrote encouraging people to vaccinate their children.

Olivia, my eldest daughter, caught measles when she was seven years old. As the illness took its usual course I can remember reading to her often in bed and not feeling particularly alarmed about it. Then one morning, when she was well on the road to recovery, I was sitting on her bed showing her how to fashion little animals out of coloured pipe-cleaners, and when it came to her turn to make one herself, I noticed that her fingers and her mind were not working together and she couldn’t do anything.

“Are you feeling all right?” I asked her.

“I feel all sleepy,” she said.

In an hour, she was unconscious. In twelve hours she was dead.

The measles had turned into a terrible thing called measles encephalitis and there was nothing the doctors could do to save her. That was twenty-four years ago in 1962, but even now, if a child with measles happens to develop the same deadly reaction from measles as Olivia did, there would still be nothing the doctors could do to help her.

On the other hand, there is today something that parents can do to make sure that this sort of tragedy does not happen to a child of theirs. They can insist that their child is immunized against measles. I was unable to do that for Olivia in 1962 because in those days a reliable measles vaccine had not been discovered. Today a good and safe vaccine is available to every family and all you have to do is to ask your doctor to administer it.
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George Birchenough @gobletcellguy.bsky.social · 11/02/2025
Just in case any new #mucus, #Goblet cell or #mucin folks have joined up recently, we have a small but growing starter pack for this area - let me know if you want in 🫡 go.bsky.app/7Z84CmG
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George Birchenough @gobletcellguy.bsky.social · 10/02/2025
Yes
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George Birchenough @gobletcellguy.bsky.social · 10/02/2025
Now that we're into #GPCR biology, I get to include (what I'm sure is) a very original joke in my journal club presentation...
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Reposted by George Birchenough
Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 23/07/2024
Sadie Schaus gives an interesting, well presented talk showing that Ruminococcus digestion of mucin (specifically MUC2) releases nutrients that support B. Theta growth. This is important because mucin can contain over 100 types of molecules! journals.asm.org/doi/full/10.... #BeneficialMicrobes
journals.asm.org
Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron | mBio
An important facet of maintaining healthy symbiosis between host and intestinal microbes is the mucus layer, the first defense protecting the epithelium from lumenal bacteria. Some gut bacteria degrad...
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Reposted by George Birchenough
Thaher Pelaseyed @tpelaseyed.bsky.social · 13/12/2024
How do massive megaDalton-sized transmembrane mucins reach the plasma membrane in intestinal epithelial cells? 🧐 Using proximity labeling, proteomics, and CRISPR KO, we uncovered key roles for MYO1B, MYO5B, and SNX27 in mucin transport. portlandpress.com/biochemj/art... #mucins #glycotime
portlandpress.com
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes
A dense glycocalyx, composed of the megaDalton-sized membrane mucin MUC17, coats the microvilli in the apical brush border of transporting intestinal epithelial cells, called enterocytes. The formatio...
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Reposted by George Birchenough
Nature Portfolio @natureportfolio.nature.com · 08/02/2025
Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, which they degrade to completion, according to a Nature Microbiology paper. 🧪
go.nature.com
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology
Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, which they degrade to completion.
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Reposted by George Birchenough
Joram Mooiweer @jorammooiweer.bsky.social · 27/01/2025
Its stories like this that makes me incredibly excited! A gut immune–epithelial circuit regulating tolerance to food: Goblet cell protein RELMβ disrupts tolerance by depleting microbiome-derived indoles needed for protective Tregs. #microbiome #immunity #ImmunoSky www.nature.com/articles/s41...
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Eduardo Villablanca @ejvillablanca.bsky.social · 25/01/2025
Dear mucosal immunologists! Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open. Register and see you this July in Aachen! 👇🏼 emig2025.de @petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
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Thaher Pelaseyed @tpelaseyed.bsky.social · 22/12/2024
🎄 Santa came early this year!🎄 We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges. insight.jci.org/articles/vie... #mucins #glycotime #Crohns #gut
insight.jci.org
JCI Insight - MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease
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epithelial mechanics fan club @epimechfc.bsky.social · 21/12/2024
What are lumens and how do forces control tissue form and fate through lumen size? Join me, @dhirajindana.bsky.social, in this short thread to explore this question through some fascinating papers.
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Michael Fischbach @mfgrp.bsky.social · 11/12/2024
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
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Jens Puschhof @jenspuschhof.bsky.social · 07/12/2024
#Colorectal #Cancer #Starterpack. Patient Advocates, Scientists, Physicians, Institutes and Journals with a focus on Colorectal Cancer. Please comment/text to be added! go.bsky.app/PGqU6zP
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TRAstonDrs @castltrastondrs.medsky.network · 05/12/2024
#Medsky🧪 #oncosky The study found that aging suppresses tumorigenesis and stemness in 🫁 by promoting a functional iron insufficiency in the alveolar epithelium. via @TuomasTammela @xueqianzhang.bsky.social @naturecomms.bsky.social www.nature.com/articles/s41...
nature.com
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature
Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.
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George Birchenough @gobletcellguy.bsky.social · 03/12/2024
Very happy (and somewhat shocked) to have been awarded an #ERC #CoG grant to study how cervical #mucus prevents intrauterine infection and #preterm birth... looking forward to meeting a new mucosal community! (Watch this space for project linked job ads 🤩)
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Kate Bevan @katebevan.com · 03/12/2024
The Guardian is an absolute swamp of junk "science". I miss the days when actual scientists and experts wrote its science blogs.
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George Birchenough @gobletcellguy.bsky.social · 02/12/2024
Interesting new paper from the Xavier lab - identifying (among other things) a possible link between microbiota-dependent regulation of regionally restricted #gobletcell subsets via ILC2s: www.nature.com/articles/s41...
nature.com
Spatially restricted immune and microbiota-driven adaptation of the gut - Nature
Intestinal regionalization is characterized by robust and resilient structural cell states and the intestine can adapt to environmental stress in a spatially controlled manner through crosstalk betwee...
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Markus Deserno @markusdeserno.bsky.social · 30/11/2024
Holy smoke—James Saenz @jamessaenz.bsky.social goes full Marie Kondo on Mycoplasma mycoides and eliminates all but two lipids from its membrane. And of course, one of them is cholesterol! 😅 The other one is a sneaky diether lipid which M. mycoides cannot remodel. Cool!!! rdcu.be/d1Uff
rdcu.be
A tuneable minimal cell membrane reveals that two lipid species suffice for life
Nature Communications - All cells are encapsulated by a membrane of complex lipidic composition, and understanding the roles of different lipids in membrane function is experimentally challenging...
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Alex Loy @loyteam.bsky.social · 19/09/2023
There is a new 🐁 gut bacterium on the block that likes to hang out with other bacteria that feed it with taurine and bullies some pathogens Please welcome Taurinivorans muris 💩🦠🧫 #Taurinivorans #taurine #sulfide #H2S #bileacids #metabolism #microbiome #pathogen #prophage
nature.com
Ecophysiology and interactions of a taurine-respiring bacterium in the mouse gut - Nature Communicat...
Authors utilise a multi-omics approach for the ecophysiological characterization of a taurine-respiring mouse gut bacterium.
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George Birchenough @gobletcellguy.bsky.social · 30/11/2024
Happy to see our latest preprint shared on Bluesky! Check it out if you're interested in how the colons #mucus barrier system develops in newborn mice
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George Birchenough @gobletcellguy.bsky.social · 30/11/2024
#mucus #gobletcell #mucin starterpack now up and running! It's a short list so far so please let me know if you want to be added to it 🦠 go.bsky.app/7Z84CmG
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George Birchenough @gobletcellguy.bsky.social · 23/11/2024
Do we need a #mucus #mucin #gobletcell starter pack? Guess it could be quite small... Thoughts @mucusman.bsky.social @mucubacter.bsky.social @tpelaseyed.bsky.social ?
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Holden Thorp @holdenthorp.bsky.social · 22/11/2024
By popular demand @science.org is on Bluesky!! No posts until after Thanksgiving, but stand by! @karaestellepowers.bsky.social @kakape.bsky.social @jakeyeston.bsky.social
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Society for Mucosal Immunology @societymucosalimm.bsky.social · 19/11/2024
🌟 Exciting News! 🌟 The Society for Mucosal Immunology is now on Bluesky! Join us as we continue advancing mucosal immunology with engaging discussions, research highlights, and community updates. 🌍🔬 👉 Find us here: socmucimm.org @mucosalimmunol.bsky.social #MucosalImmunology #ScienceCommunity
socmucimm.org
Society for Mucosal Immunology | Advancing Research, Education, & Collaboration
The Society for Mucosal Immunology is a diverse group of more than 700 scientists and clinicians from 34 countries advancing research and education related to the field of mucosal immunology.
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Bjo:rn Schro:der @mucubacter.bsky.social · 16/11/2024
Happy weekend everyone! So great to see how this sunny space is growing!🦋 We are working on the interaction between #diet, #gutmicrobiota 🦠🧫and #mucus in health and disease: www.mucubacter.org. Happy to connect! #MicrobiomeSky #MicroSky #GIsky #IBD #GIresearch #microbiome
mucubacter.org
(no title)
Bjoern O. Schroeder lab with a focus on gut microbiota and intestinal mucosal barrier function
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Shai Bel (The Mucus Man) @mucusman.bsky.social · 18/11/2024
🎵"It's just another #MucusMonday" Alcian blue staining of (abnormal) mucus secretion (blue) filling the colonic lumen. 🧪 🧫 🔬 🦠
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Denis - The COVID Info Guy @thecovidinfoguy.bsky.social · 18/11/2024
COVID-19 hitches a ride on mucus to spread deep into lungs, live imaging shows. Study: www.nature.com/articles/s41... Source: archive.md/VSzDS
November 18, 2024

 Editors' notes
COVID-19 hitches a ride on mucus to spread deep into lungs, live imaging shows

by Olivia Dimmer, Northwestern University
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Lior Pachter @lpachter.bsky.social · 18/11/2024
Seems that @biorxivpreprint.bsky.social ought to consider adding links to @bsky.app posts given the mass transfer of scientists from Twitter to @bsky.app that is taking place.
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Altmetric @altmetric.com · 18/11/2024
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
docs.bsky.app
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
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Ivan Zanoni @lozanzi.bsky.social · 17/11/2024
#LocationLocationLocation & #EveryCellIsAnImmuneCell!! Check out the final version just out today of our Trends in Immunology review on the regionalization of the immune response along the respiratory tract!! dlvr.it/TG3Qzc
dlvr.it
Regional specialization within the mammalian respiratory immune system
The respiratory tract is exposed to infection from inhaled pathogens, including viruses, bacteria, and fungi. So far, a comprehensive assessment that integrates common and distinct aspects of the immu...
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Edelblum Lab @edelblumlab.bsky.social · 13/11/2024
Our recent paper revealing the effects of type I #IFN on γδ intraepithelial cells and uncovers a TCRγδ-independent response: ow.ly/ZYqK50U0Bwg and was named a November’s #JI_TopRead 🤩 #gdTcells #immunology #GIresearch
ow.ly
Type I IFN Induces TCR-dependent and -independent Antimicrobial Responses in γδ Intraepithelial Lymphocytes
Key Points. Type I IFN induces γδ IEL IFN-γ production in a TCR-dependent manner ex vivo.In vivo, the rapid γδ IEL antimicrobial response to type I IFN is
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