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Christian Diener

@cdiener.com
1.1K followers 1.4K following 147 posts

Lifelong relationship with microbes, now studying them for a living. Assistant Professor at MedUni Graz. Opinions are my own. He/him 🦠+💻=❤️ More socials at cdiener.com. Lab website at dienerlab.com.

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Reposted by Christian Diener
David Bikard @dbikard.bsky.social · 21/09/2026
New paper from the lab, out in Nature Microbiology. We ran CRISPRi screens to ask what genes E. coli needs in order to live in a gut and what this can tell us about the gut environment itself. doi.org/10.1038/s41564-026-02471-8
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Guillaume Urtecho @gogurtecho.bsky.social · 02/09/2026
Excited to share the first paper from the Urtecho Lab! We built a framework to move fecal microbiota transplantation (FMT) from a black-box therapy to precision medicine for gut disorders 🧵 doi.org/10.1080/19490976.2026.2725403 #Microbiome. #OpenAccess
doi.org
Metagenome-scale modeling to assess microbiome metabolic complementarity for precision microbiota transplantation therapies
Fecal microbiota transplantation (FMT) holds therapeutic promise beyond recurrent Clostridioides difficile infection, but clinical outcomes remain unpredictable and donor-selection strategies remai...
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Christian Kost @kostchristian.bsky.social · 24/08/2026
Very happy that our paper Obligate cross-feeding of metabolites is common in soil microbial communities just came out in Nature Microbiology. See here 👇 Paywalled version: www.nature.com/articles/s41... Free read-only version: rdcu.be/fBHAb
nature.com
Obligate cross-feeding of metabolites is common in soil microbial communities - Nature Microbiology
Cultivation-dependent techniques, computational analyses and genome-scale metabolic models show widespread amino acid auxotrophies, suggesting that soil microorganisms exist within integrated ecologic...
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NFDI4Microbiota @nfdi4microbiota.bsky.social · 17/08/2026
📢 Flex Funds Call for 2027 is now open! Contribute to advancing #FAIRData, #OpenScience, infrastructure, workflows, or training in #microbiology! 💶 Funding: €10,000–€40,000/project 📅 Funding period: Apr–Dec 2027 📆 Application deadline: Oct 11 👉️ More details: nfdi4microbiota.de/newsroom/fle...
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BF Francis Ouellette @bffo.bsky.social · 13/08/2026
From @jfy133.genomic.social.ap.brid.gy @maxibor.bsky.social @christinawarinner.bsky.social et al., in @plos.org #Computational #Biology | De novo assembly and authentication of ancient DNA metagenomes with nf-core/mag | #Education #Genomics #Microbes | 🧬🖥️🧪🔓 ⬇️ journals.plos.org/ploscompbiol...
journals.plos.org
De novo assembly and authentication of ancient DNA metagenomes with nf-core/mag
Author summary Advancements in genomic sequencing analyses are increasingly allowing researchers to reconstruct the genomes of microbial ‘dark matter’—those microbial species that are difficult to iso...
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Morten Kam Dahl Dueholm @mkddueholm.bsky.social · 10/08/2026
Check out the MiDAS global genome catalog preprint! We applied Nanopore long-read metagenomics to 83 selected samples from the MiDAS 4 global survey of wastewater treatment plants to create a genome catalog covering all core genera in the activated sludge microbiome. www.biorxiv.org/content/10.6...
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Christian Diener @cdiener.com · 11/08/2026
Absolutely bonkers how amazing this speaker lineup is. Can't make it myself, but this looks like a great conference here.
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Anna Kuchina @annabiosys.bsky.social · 04/08/2026
Proud to share our single-cell transcriptomics approach for the microbiome by instrument-free split-pool barcoding - metaSPLiT, developed by the incredible @monochamussutor.bsky.social together with @gibbological.bsky.social, @cdiener.com, et al. at @isbscience.org
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 23/07/2026
Dear microbiome enthusiasts: I'm excited to be moving my lab to New York University this fall (& the NYU Institute for Engineering Health); with joint-appointment @isbscience.org I'm hiring a postdoc @ NYU to look at diet-driven evolution in the gut: apply.interfolio.com/189980 Please share! 🦠🤓
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 01/08/2026
Phenotypic heterogeneity in the human gut microbiome revealed by subspecies-resolution single-cell transcriptomics www.biorxiv.org/content/10.64898/20…
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Guillaume Méric @gmeric.bsky.social · 21/07/2026
New reading list for July, before the summer break! ☀️ Some studies that caught my eye in the field of microbiome research, population health, microbial genomics, ecology, evolution and other topics. Comments my own. Hope this will be useful to some of you! mericlab.com/blog/2026-07/
mericlab.com
Reading list: Intestinal nutrition, microbiome GWAS, GLP-1 & AI stuff
Some new articles in the reading list. I’ll probably do a little break for those during the summer holidays. Have a good one! (a) Microbiome and population health Genomic landscape of the human vagina...
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Daan Speth @daanspeth.bsky.social · 26/06/2026
I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets. More info globdb.org 🦠🖥️🧬
globdb.org
home | GlobDB
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Christian Diener @cdiener.com · 14/06/2026
Interesting article by Glass et al. on using metabolic modeling to find new antibiotics for the vaginal microbiome.
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Medizinische Universität Graz @medunigraz.at · 25/05/2026
Milliardenkürzungen bei Unis? Das hätte massive Folgen für die Steiermark! Setzen wir bei den Demos ein Zeichen: 🟢 Wien: 27. Mai 2026, 13 Uhr, Hauptgebäude der Universität Wien, Universitätsring 1​ 🟢 Graz: 28. Mai 2026, 14.30 Uhr, Wilhelm-Fischer-Allee am Stadtpark, Graz #unisretten
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Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com · 20/05/2026
New online! Sequencing what we eat
dlvr.it
Sequencing what we eat
Nature Reviews Gastroenterology & Hepatology, Published online: 19 May 2026; doi:10.1038/s41575-026-01215-7Dietary assessment commonly relies on asking people what they remember eating. Genomic methods can change this assessment, paralleling how DNA sequencing revolutionized microbiology. By identifying consumed foods directly from stool, these approaches offer an objective, scalable alternative that gastroenterology researchers can begin using today.
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Nature Reviews Microbiology @natrevmicro.nature.com · 08/05/2026
New online! Next-generation probiotics: an outlook into current applications and future developments
dlvr.it
Next-generation probiotics: an outlook into current applications and future developments
Nature Reviews Microbiology, Published online: 08 May 2026; doi:10.1038/s41579-026-01311-0In this Review, Kern, Tofield, Frame and Elinav discuss recent advances in the design of next-generation probiotics, from identification of candidates to therapeutic applications across diverse disease contexts, and highlight major challenges and the potential of artificial intelligence to develop effective, personalized probiotics with therapeutic functions.
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Martin Polz @polzlab.bsky.social · 06/05/2026
Very excited to share our new paper out in Nature. Congrats to Xiaoqian (Annie) Yu and all the coauthors. www.nature.com/articles/s41...
nature.com
Genome-wide sweeps create ecological units in the human gut microbiome - Nature
Genome-wide selective sweeps commonly occur in the human gut microbiome and can spread across the world within decades to produce epidemic-like population structures.
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Christian Diener @cdiener.com · 23/04/2026
I like how all the p-values are like 10^-300. Take that power analysis.
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A. Murat Eren (Meren) @merenbey.bsky.social · 16/04/2026
How every layer of science's "self-correcting machinery" failed when Iva Veseli and I simply wanted to reproduce the findings of a high-profile study on gut microbiome and autism: merenlab.org/2026/04/15/u...
merenlab.org
Unfalsifiable by Design: A Year of Trying and Failing to Reproduce a Human Microbiome and Autism Study
The myth of open data, reproducibility, responsibility, and accountability in science, and your role in it
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Guim Aguadé-Gorgorió @guimaguade.bsky.social · 07/04/2026
Microbial communities can harbor many species that do not coexist in pairs, yet can coexist in the full community. Here we provide the mathematical foundations of emergent coexistence, and explain why it can't be predicted from pairwise tests journals.plos.org/ploscompbiol...
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Anna Kuchina @annabiosys.bsky.social · 17/03/2026
Paper out: Profiling of lytic phage infection in individual B. fragilis cells with bacterial scRNA-seq. Congratulations Anika Gupta, Norma Morella, @monochamussutor.bsky.social Dmitry Sutormin et al, in collaboration with Georg Seelig (UW) and Neel Dey (Fred Hutch). www.nature.com/articles/s41...
nature.com
Dynamics of phage-host interactions in Bacteroides fragilis resolved by single-cell transcriptomics - Nature Communications
Phage-bacteria interactions are typically studied in bulk culture, which obscures cell-cell differences. Here the authors study phage-bacteria interactions using single-cell transcriptomics, identifyi...
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Cluster of Excellence 'MicroPlanet' @microbesplanet.bsky.social · 06/03/2026
Mikrobiom: Hype oder klinische Evidenz? Am 20.05.2026 bietet die Fortbildung „Medizinische Mikrobiomforschung“ fundierte Einordnung, organsiert von @medunigraz.at, JKULinz & @fwf-at.bsky.social CoE MicroPlanet Aktuelle Forschung, Evidenzlage zu Diagnostik, FMT, Probiotika.
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Nature Microbiology @natmicrobiol.nature.com · 26/02/2026
Out Now! Gut bacteria ammonia production restores acetylcholine neurotransmission and bowel motility #MicroSky
go.nature.com
Gut bacteria ammonia production restores acetylcholine neurotransmission and bowel motility
Nature Microbiology, Published online: 26 February 2026; doi:10.1038/s41564-026-02292-9Acetylcholine levels are reduced in gut dysmotility conditions. We find that gut acetylcholine levels induce a compensatory increase in gut microbiota urease activity and ammonia production. By upregulating presynaptic Cav2.1 calcium channels in enteric neurons, ammonia enhances calcium influx and restores acetylcholine release neurotransmission, revealing a microbiota-driven mechanism that preserves gut motility.
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 19/02/2026
Our latest is out today in @plosbiology.org: "Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials" @isbscience.org @uwbioe.bsky.social @uwgenome.bsky.social doi.org/10.1371/jour...
doi.org
Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials
Prebiotic and probiotic interventions can induce therapeutically relevant shifts in the human microbiome, but their effects are variable across individuals. This study shows that metabolic models can ...
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Catalina Cuparencu @catalinacuparencu.bsky.social · 30/01/2026
I joined efforts with D.A. Lucassen, @cdiener.com @gibbological.bsky.social and T. Wilson and got a really nice paper out on how to best integrate modern dietary assessment technologies to improve the accuracy of the current tools. Have a look here 👇 www.nature.com/articles/s43...
nature.com
Integration of modern technologies to advance dietary assessment
Nature Food - Accurately measuring dietary intake has long been a challenge in nutrition research. Integrating emerging tools with multisampling strategies and a dietary assessment methodology...
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 26/01/2026
Check out our review on emerging technologies for diet tracking in Nature Food. 👇 This paper was led by @catalinacuparencu.bsky.social, with @cdiener.com and others: www.nature.com/articles/s43... @isbscience.org @uwbioe.bsky.social @uwgenome.bsky.social
nature.com
Integration of modern technologies to advance dietary assessment - Nature Food
Accurately measuring dietary intake has long been a challenge in nutrition research. Integrating emerging tools with multisampling strategies and a dietary assessment methodology aligned with the rese...
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Gut Microbiota for Health @gmfhx.bsky.social · 25/01/2026
How do we really assess dietary intake—and where is the field heading next? This is the topic of the keynote lecture at #GMFH2026 by Lawrence David. 👉 Register now & join us www.gutmicrobiotaforhealth.com/port… 📍Porto | March 14–15
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EMBO @embo.org · 17/01/2026
We mourn the passing of Peer Bork, EMBO Member since 2000: www.embl.org/news/embl-announcement…
embl.org
In remembrance of Peer Bork  | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General. 
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AnniZLab: [🦠, 🧬 , ✨] @annizlab.bsky.social · 14/01/2026
So happy to host Dr. Xiaoqian (Annie) Yu - soon starting her lab at University of Montreal! She used population genomics and large data analysis to group gut microbiome into ecological units based on sweep events (major revision at Nature)! www.biorxiv.org/content/10.1... #microsky #microbiomesky 🧪🦠
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Brochado Lab @brochadolab.bsky.social · 14/01/2026
📢 We are hiring 📢 1st round of recruiting for our ERC project BacImmune-Decode! @erc.europa.eu We are looking for a postdoc for wet-lab work on regulation of phage defence systems in bacteria using high-throughput microbial genetics. Check it out: lnkd.in/es7AE968 #Hiring #Postdoc #Microbiology
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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Isabella Wagner 🧠🦠 @isabellacwagner.bsky.social · 08/01/2026
Apply now: 1 Postdoc + 1 PhD position, Anderson-Wagner group @univie.ac.at Focus: gut microbial effects on hippocampus & memory 🧠🦠 #PostdocJobs #Microbiome #AcademicJobs #PhDposition Postdoc Ad: careers.univie.ac.at/en/postdoc/e... > Psychology PhD Ad: careers.univie.ac.at/en/praedoc/p... > CoBeNe
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NFDI4Microbiota @nfdi4microbiota.bsky.social · 06/01/2026
📢 Our Q1 2026 Newsletter is live! Get the latest project updates, community news, and insights from the NFDI4Microbiota ecosystem. 👉 Read here: nfdi4microbiota.de/newsroom/new... 📬 Don’t miss future updates—subscribe to our mailing list: lists.nfdi.de/postorius/li...
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Daniel Figeys @dfigeys.bsky.social · 06/01/2026
Are you interested in #metaproteomics? We have a senior scientist position in my lab focused on metaproteomics, and xenobiotic- #microbiome -host interactions. Check it out. jobs.quadram.ac.uk/Details.asp?...
jobs.quadram.ac.uk
Quadram Institute
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Christian Kost @kostchristian.bsky.social · 27/11/2025
I am very excited to announce that a fully funded PhD position is available in my group. Topic: Synergistic coevolution in mono-specific and multi-species microbial consortia Please RT or forward this information to interested candidates. Deadline: 11.01.26 More info: shorturl.at/f1TuF
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Alex Loy @loyteam.bsky.social · 16/12/2025
📢 20 postdoctoral positions (full-time, 4 years) for outstanding female scientists 👩‍🔬 🔬 @univie.ac.at The E-STEEM programme call opens January 7th, 2026 and closes March 3rd, 2026. careers.univie.ac.at/en/postdoc/e... I participate as a host...
careers.univie.ac.at
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Isabella Wagner 🧠🦠 @isabellacwagner.bsky.social · 16/12/2025
Open postdoc position!🚨 Passionate about gut microbes 🦠 and the brain 🧠? We are an interdisciplinary group at the Faculty of Psychology & @cemess.bsky.social 🌍 @univie.ac.at and invite individuals who self-identify as female. Details: 4 years, full-time ➡️ careers.univie.ac.at/en/postdoc/e...
careers.univie.ac.at
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Matthew Asker @masker.science · 10/12/2025
Up to 10 doctoral positions at the Max Planck Institute for Evolutionary Biology now open for application! Start date September 2026. More info here: www.evolbio.mpg.de/imprs
Poster advertising doctoral positions in 2026 at the International Max Planck Research School for Evolutionary Biology.
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Nature Metabolism @natmetabolism.nature.com · 09/12/2025
Top #Citations 2025: 9️⃣🧪 @cdiener.com @gibbological.bsky.social et al ( @isbscience.org @medunigraz.at ) present a new method to estimate dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
bit.ly
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
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Michael Wagner @michiwagner4.bsky.social · 27/11/2025
📢 New preprint on bioRxiv! We introduce V4-EXT, a revised 16S rRNA V4 primer set that dramatically improves detection of Patescibacteria and other undersampled lineages ✅ 938 samples ✅ More novel ASVs Primer choice matters 👀 www.biorxiv.org/content/10.1... @ppjevac.bsky.social #HuifengHu
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nf-core @nf-co.re · 25/11/2025
🧑‍💻 Need help with #nfcore #nextflow #bioinformatics pipelines, running or developing? We are merging the 🌍 Eur/M.E./Afr and the 🌎 Americas weekly helpdesk. Please join our host @vagkaratzas.bsky.social, nf-core maintainer, this Thursday at 14:30 CET | 08:30 ET on play.workadventu.re/@/nf-core/nf...
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David Ho @davidho.bsky.social · 15/11/2025
Come be my colleague at University of Hawaiʻi at Mānoa. We're hiring an assistant professor in Ocean Biogeochemical Modeling. 🌊
schooljobs.com
Career Opportunities at the University of Hawai'i | University of Hawai'i
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 13/11/2025
📣 Join us for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems". co-director - @flash-point.bsky.social 🦠💥 It's free, & we have an amazing line-up of speakers! Dec. 12th. Please share! isbscience.org/2025-isb-vir...
isbscience.org
2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB)
Symposium Schedule All presentation times are shown in Pacific Daylight Time (GMT -07:00 / UTC -07:00) Time Talk / Session 9:00 Welcoming remarks by Sid Venkatesh Session One: Neural Effects
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 11/11/2025
Dr. Nick Quinn-Bohmann will present a Keynote Talk at this year's Future of the Microbiome Winter Summit (Nov. 18-20). He'll talk about his work on using community-scale metabolic modeling to design personalized, microbiome-informed interventions. futureofmicrobiome.com/winter-summi...
futureofmicrobiome.com
Winter Summit 2025 | The Future of Microbiome
Future of the Microbiome2025 Winter Summit Join us November 18-20, 2025! REGISTER NOW The Future of the Microbiome Winter Summit explores what’s next for the microbiome industry, bringing together bri...
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Christian Kost @kostchristian.bsky.social · 05/11/2025
Less than a week remains to apply to this exciting PhD position and join my team at Osnabrück University 👇
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Ran Blekhman @blekhman.bsky.social · 05/11/2025
🧬 🦠 🏙️ Urban vs rural lifestyles create dramatically different gut microbiomes. But how do these different gut microbiomes affect the host? Excited to share our new paper: www.biorxiv.org/content/10.1...
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Javier Santoyo @jsantoyo.bsky.social · 03/11/2025
LorBin: efficient binning of long-read metagenomes by multiscale adaptive clustering and evaluation. #LongRead #Metagenomics #MAGs #BinningMethods #UnsupervisedBinning @natcomms.nature.com www.nature.com/articles/s41...
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Sebastian Schmidt @tsbschm.bsky.social · 31/10/2025
Great to see this finally published! Metalog: curated and harmonised contextual data for global metagenomics samples now out in @narjournal.bsky.social academic.oup.com/nar/advance-...
academic.oup.com
Metalog: curated and harmonised contextual data for global metagenomics samples
Abstract. Metagenomic sequencing enables the in-depth study of microbes and their functions in humans, animals, and the environment. While sequencing data
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Solid Evidence @solidevidence.bsky.social · 31/10/2025
Can you take a quarter cup of composite sewage, simply ask ‘what’s in there?’, and find out all of the pathogens circulating in that community? That is the question we asked in our latest pre-print. Turns out you can. 1/ www.medrxiv.org/content/10.1...
medrxiv.org
Untargeted longitudinal ultra deep metagenomic sequencing of wastewater provides a comprehensive readout of expected and unexpected viral pathogens
Wastewater surveillance has become a powerful tool to monitor circulating viruses at a community level. Currently, most wastewater surveillance efforts use target-based approaches such as quantitative...
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 18/10/2025
Looks interesting 👀: Distinguishing diet- and microbe-derived metabolites in the human gut microbiomejournal.biomedcentral.com/articles/10....
microbiomejournal.biomedcentral.com
Distinguishing diet- and microbe-derived metabolites in the human gut - Microbiome
Background Human gut microbes metabolize food and host secretions, consuming and producing small molecules that are important to health and homeostasis. Here, we present an atlas of diet- and microbio...
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starchlab.bsky.social @starchlab.bsky.social · 14/10/2025
Come and do a PhD with me! Are you looking for a PhD project at the intersection of #microbiome and #food science? This project, in collaboration with ADM milling, will explore novel microbiome targeted food ingredients
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