Sign in

George Birchenough

@gobletcellguy.bsky.social
817 followers 1.2K following 47 posts

Updates from the Birchenough Lab, one of the Mucin Biology Groups based at the University of Gothenburg. All things goblet cell, mucus and mucin. Check us out: www.birchenoughlab.org www.medkem.gu.se/mucinbiology

PostsRepliesMedia
Reposted by George Birchenough
Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 15/05/2025
Microbiota colonising the new born colon prime goblet cells producing the gut-protective mucus 📷 Åsa Johansson et al @gobletcellguy.bsky.social University of Gothenburg in @jem.org ➡️ bpod.org.uk/archive/2025...
052
George Birchenough @gobletcellguy.bsky.social · 05/05/2025
Happy to see this finally published 🙌 Thanks to the editors and reviewers for the constructive process 😎
1176
George Birchenough @gobletcellguy.bsky.social · 19/04/2025
Here is black mirror's creator Charlie Brooker guest hosting a long running British satirical news show the same week that Trump was first elected, enjoy 🫠 youtu.be/LZIDgYEvDn4?...
youtu.be
Charlie Brooker HIGNFY Intro - 11/11/2016
YouTube video by BluebackHotrod
020
Reposted by George Birchenough
Lars Vereecke @larsvereecke.bsky.social · 24/03/2025
Abstract deadline for #GGIG2025 is approaching fast! Don’t miss your chance to share your research at the 5th Ghent Gut Inflammation Group Meeting! 🧬🦠 www.vibconferences.be/events/5th-g...
vibconferences.be
5th Ghent Gut Inflammation Group Meeting
15-16 May 2025, Ghent, Belgium Host-microbiota interactions in health and disease
032
Reposted by George Birchenough
Mucosal Immunology @mucosalimmunol.bsky.social · 28/03/2025
Which cells use Myd88 to control Segmented Filamentous Bacteria colonization? Here work explores the hematopoietic MyD88/IL-22 axis during SFB growth. www.mucosalimmunology.org/article/S193...
152
George Birchenough @gobletcellguy.bsky.social · 22/03/2025
My colleague Sjoerd van der Post just quietly dropped a preprint defining the interaction of the #ETEC SPATE family enzyme EatA with intestinal Muc2, providing some fascinating insights into host specific #mucus degradation 🤯. Check it out: www.biorxiv.org/content/10.1...
biorxiv.org
Degradation of the intestinal mucus layer by the ETEC protease EatA is species specific determined by the structure of the MUC2 mucin
Enterotoxigenic Escherichia coli (ETEC) infections are a leading cause of diarrheal illness, responsible for an estimated 100,000 deaths annually. ETEC pathogenesis is driven by various virulence fact...
082
George Birchenough @gobletcellguy.bsky.social · 20/03/2025
Nice discussion around the ongoing #glycoRNA debate, check out the comments
020
Reposted by George Birchenough
Lars Vereecke @larsvereecke.bsky.social · 11/03/2025
In our lates review, we explore new insights into the gut-joint axis, a connection is not absolute. A causal role for the microbiota is context-dependent, and arthritis can also arise independently through sterile mechanisms: authors.elsevier.com/a/1kkn55Eb0R... #GutJointAxis
authors.elsevier.com
011
George Birchenough @gobletcellguy.bsky.social · 26/02/2025
Say what now?!
021
Reposted by George Birchenough
Prof. Ruth Ley FRS @microbiome.bsky.social · 25/02/2025
So excited to share this latest work by @kelseyhuus.bsky.social !!! She shows that flagellin in the human gut affects whether or not people develop fever in response to vaccine, and the amount of flagellin reflects diet
39230
George Birchenough @gobletcellguy.bsky.social · 23/02/2025
Fair point, but I think there are issues with the paper itself - missing methods regarding enzymatic treatment of colonic mucus, amongst others.
010
George Birchenough @gobletcellguy.bsky.social · 22/02/2025
I think it's safe to say that the reviewers were not into glycobiology, which is a shame because it's the mechanistic basis of the paper.. 🫠
130
George Birchenough @gobletcellguy.bsky.social · 21/02/2025
Here's another for you, also a Nature family journal funnily enough 😅: www.nature.com/articles/s41...
451
Reposted by George Birchenough
Daniel Bojar @dbojar.bsky.social · 18/02/2025
glycowork v1.5 is now released! We're excited to see the cool things you'll be doing with it:-) Lots of new & improved functionality, check out the Release notes for the full change log:
github.com
Release v1.5.0 · BojarLab/glycowork
Changelog [1.5.0] Added ✨ Added type hints to all functions (e6721a1) Added CodeCov shield to track PyTest test code coverage (23d6456) Added more PyTest unit tests (e.g., 0c94995, 23d6456, 5a99d6...
072
Reposted by George Birchenough
Christian Diener @cdiener.com · 18/02/2025
Happy to announce that MEDI, our method to quantify dietary intake through metagenomics is out now. 🧬 🧪🧫🦠 www.nature.com/articles/s42... #metagenomics #microbiome #microbiomesky So what is MEDI? A combination of two things:
nature.com
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
110040
Reposted by George Birchenough
Olivia Coleman @ocoleman.bsky.social · 17/02/2025
For all the #mucus fans out there who believe in our knight in slimy armour and want to join the starter pack 👇 contact @gobletcellguy.bsky.social #mucusmatters
021
Reposted by George Birchenough
Hall Lab @halllab.bsky.social · 11/01/2025
1/ 🚨 New preprint alert! 🚨 We’re thrilled to share our latest work exploring microbiome & genomic #Bifidobacterium co-evolutionary & functional signatures across diverse animal hosts. This has been a long time coming, & huge credit to Magda for her incredible hard work as first author! 🐾✨👇
doi.org
Host-specific microbiome and genomic signatures in Bifidobacterium reveal co-evolutionary and functional adaptations across diverse animal hosts
Animal hosts harbour divergent microbiota, including various Bifidobacterium species and strains, yet their evolutionary relationships, and functional adaptions remain understudied. By integrating tax...
16534
George Birchenough @gobletcellguy.bsky.social · 17/02/2025
This was ultimately traced back to significant flagellar upreg in the FimH KO bugs, but I think that an important moral of the story here is that for highly motile bugs, the mucus "barrier" really isn't 🫣
000
George Birchenough @gobletcellguy.bsky.social · 17/02/2025
Interestingly loss of the #FimH adhesin disrupted UPEC mucosal associations in vivo, but weirdly dramatically increased its capacity to penetrate the mucus barrier ex vivo
110
George Birchenough @gobletcellguy.bsky.social · 17/02/2025
This was a fun study from Scott Hultgrens lab that we contributed to, led by Philippe Azimzadeh, looking at #UPEC interactions with colonic #mucus: www.science.org/doi/10.1126/...
science.org
Mechanisms of uropathogenic E. coli mucosal association in the gastrointestinal tract
Inverse regulation of flagella and type 1 pili facilitates access to colon mucus by uropathogenic E. coli.
1126
Reposted by George Birchenough
Lucy Crouch @lucyicm.bsky.social · 31/01/2025
New paper out today from the lab on Akkermansia muciniphila 🦠and how it breaks down host glycans! Very proud of my group, especially @cassiebakshani.bsky.social who did an amazing job. @naturemicrobiol.bsky.social www.nature.com/articles/s41...
nature.com
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology
Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, wh...
312842
Reposted by George Birchenough
Maryse Berkhout @maryseberkhout.bsky.social · 12/02/2025
#microsky
072
Reposted by George Birchenough
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 13/02/2025
Discovery of a new Cu-dependent cellulose degrading enzyme for biomass conversion #glycotime (trying to overlook the extraneous proton, see if you can find it) www.nature.com/articles/s41...
nature.com
A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion - Nature
A metalloenzyme capable of oxidatively cleaving cellulose, found in a microbial community specialized in lignocellulose degradation, could enable sustainable biofuel production.
46913
Reposted by George Birchenough
Kathryn Knoop, PhD @kknoop.bsky.social · 14/02/2025
Don’t miss #ASRI2025 in St. Paul Minnesota May 17-21. Check out fantastic talks on the Maternal, Fetal, and Neonatal Immunology and submit your abstract by 2/15! theasri.org/Abstracts-Po...
031
George Birchenough @gobletcellguy.bsky.social · 17/02/2025
Huh, not sure why that link didn't work... anyway it's pinned to my profile 😆
100
George Birchenough @gobletcellguy.bsky.social · 17/02/2025
I've added you to our mucus starter pack, please forward to anyone who might be interested :) /starter-pack-short/7Z84CmG
110
Reposted by George Birchenough
Natalia Torow @ntorow.bsky.social · 11/02/2025
Still time to submit late breaking abstract to this fantastic meeting: www.perinatal-immunity.de/en/symposium...
perinatal-immunity.de
International Symposium on Perinatal and Early Life Immunity | perinatal immunity immunology TRR 359 PILOT
012
Reposted by George Birchenough
ex-Lethality Jane @lethalityjane.bsky.social · 15/02/2025
The measles outbreak in Texas is reminding me of the public letter Roald Dahl wrote about losing his daughter to measles in 1962, just before the vaccine was publicly available.
Excerpt from a public letter Roald Dahl wrote encouraging people to vaccinate their children.

Olivia, my eldest daughter, caught measles when she was seven years old. As the illness took its usual course I can remember reading to her often in bed and not feeling particularly alarmed about it. Then one morning, when she was well on the road to recovery, I was sitting on her bed showing her how to fashion little animals out of coloured pipe-cleaners, and when it came to her turn to make one herself, I noticed that her fingers and her mind were not working together and she couldn’t do anything.

“Are you feeling all right?” I asked her.

“I feel all sleepy,” she said.

In an hour, she was unconscious. In twelve hours she was dead.

The measles had turned into a terrible thing called measles encephalitis and there was nothing the doctors could do to save her. That was twenty-four years ago in 1962, but even now, if a child with measles happens to develop the same deadly reaction from measles as Olivia did, there would still be nothing the doctors could do to help her.

On the other hand, there is today something that parents can do to make sure that this sort of tragedy does not happen to a child of theirs. They can insist that their child is immunized against measles. I was unable to do that for Olivia in 1962 because in those days a reliable measles vaccine had not been discovered. Today a good and safe vaccine is available to every family and all you have to do is to ask your doctor to administer it.
3972658311687
George Birchenough @gobletcellguy.bsky.social · 11/02/2025
Just in case any new #mucus, #Goblet cell or #mucin folks have joined up recently, we have a small but growing starter pack for this area - let me know if you want in 🫡 go.bsky.app/7Z84CmG
241
George Birchenough @gobletcellguy.bsky.social · 10/02/2025
Yes
020
George Birchenough @gobletcellguy.bsky.social · 10/02/2025
Now that we're into #GPCR biology, I get to include (what I'm sure is) a very original joke in my journal club presentation...
000
Reposted by George Birchenough
Dr. Kat Napaaqtuk❄️ @napaaqtuk.bsky.social · 23/07/2024
Sadie Schaus gives an interesting, well presented talk showing that Ruminococcus digestion of mucin (specifically MUC2) releases nutrients that support B. Theta growth. This is important because mucin can contain over 100 types of molecules! journals.asm.org/doi/full/10.... #BeneficialMicrobes
journals.asm.org
Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron | mBio
An important facet of maintaining healthy symbiosis between host and intestinal microbes is the mucus layer, the first defense protecting the epithelium from lumenal bacteria. Some gut bacteria degrad...
152
Reposted by George Birchenough
Thaher Pelaseyed @tpelaseyed.bsky.social · 13/12/2024
How do massive megaDalton-sized transmembrane mucins reach the plasma membrane in intestinal epithelial cells? 🧐 Using proximity labeling, proteomics, and CRISPR KO, we uncovered key roles for MYO1B, MYO5B, and SNX27 in mucin transport. portlandpress.com/biochemj/art... #mucins #glycotime
portlandpress.com
The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes
A dense glycocalyx, composed of the megaDalton-sized membrane mucin MUC17, coats the microvilli in the apical brush border of transporting intestinal epithelial cells, called enterocytes. The formatio...
083
Reposted by George Birchenough
Nature Portfolio @natureportfolio.nature.com · 08/02/2025
Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, which they degrade to completion, according to a Nature Microbiology paper. 🧪
go.nature.com
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion - Nature Microbiology
Biochemical characterization of 66 carbohydrate-active enzymes from the gut microorganism Akkermansia muciniphila reveals that these enzymes can break down a range of host glycans, including mucin, which they degrade to completion.
0326
Reposted by George Birchenough
Joram Mooiweer @jorammooiweer.bsky.social · 27/01/2025
Its stories like this that makes me incredibly excited! A gut immune–epithelial circuit regulating tolerance to food: Goblet cell protein RELMβ disrupts tolerance by depleting microbiome-derived indoles needed for protective Tregs. #microbiome #immunity #ImmunoSky www.nature.com/articles/s41...
0134
Reposted by George Birchenough
Eduardo Villablanca @ejvillablanca.bsky.social · 25/01/2025
Dear mucosal immunologists! Registration for the European Mucosal Immunology Group (EMIG) meeting in Aachen, Germany is now open. Register and see you this July in Aachen! 👇🏼 emig2025.de @petterbrodin.bsky.social @wiag.bsky.social @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
03018
Reposted by George Birchenough
Thaher Pelaseyed @tpelaseyed.bsky.social · 22/12/2024
🎄 Santa came early this year!🎄 We’re unwrapping an exciting discovery from our lab that reveals the critical role of the transmembrane mucin MUC17 in protecting the small intestine against bacterial challenges. insight.jci.org/articles/vie... #mucins #glycotime #Crohns #gut
insight.jci.org
JCI Insight - MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease
8165
Reposted by George Birchenough
epithelial mechanics fan club @epimechfc.bsky.social · 21/12/2024
What are lumens and how do forces control tissue form and fate through lumen size? Join me, @dhirajindana.bsky.social, in this short thread to explore this question through some fascinating papers.
2407
George Birchenough @gobletcellguy.bsky.social · 11/12/2024
Very nice - as usual. Congrats! Is the robust response to skin "colonists" that unexpected? I suppose skin breaks are quite normal infection risks, and the bugs that live on our skin are perhaps less mutualistic than those residing in the gut for example, so less pressure for tolerance?
000
Reposted by George Birchenough
Michael Fischbach @mfgrp.bsky.social · 11/12/2024
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
23693294
George Birchenough @gobletcellguy.bsky.social · 07/12/2024
Happy anniversary! Please explain the hat
110
George Birchenough @gobletcellguy.bsky.social · 07/12/2024
Excellent job - thanks 😀
010
Reposted by George Birchenough
Jens Puschhof @jenspuschhof.bsky.social · 07/12/2024
#Colorectal #Cancer #Starterpack. Patient Advocates, Scientists, Physicians, Institutes and Journals with a focus on Colorectal Cancer. Please comment/text to be added! go.bsky.app/PGqU6zP
9124
Reposted by George Birchenough
TRAstonDrs @castltrastondrs.medsky.network · 05/12/2024
#Medsky🧪 #oncosky The study found that aging suppresses tumorigenesis and stemness in 🫁 by promoting a functional iron insufficiency in the alveolar epithelium. via @TuomasTammela @xueqianzhang.bsky.social @naturecomms.bsky.social www.nature.com/articles/s41...
nature.com
Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis - Nature
Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.
2295
George Birchenough @gobletcellguy.bsky.social · 04/12/2024
Cheers man, we will celebrate in Umeå 😉
110
George Birchenough @gobletcellguy.bsky.social · 03/12/2024
Thanks, I suspect you might be right there 😅
000
George Birchenough @gobletcellguy.bsky.social · 03/12/2024
Thanks a lot Jakob!
000
George Birchenough @gobletcellguy.bsky.social · 03/12/2024
I think it's all going to my animal facility 🐁
010
George Birchenough @gobletcellguy.bsky.social · 03/12/2024
Cheers Patri 😀
010
George Birchenough @gobletcellguy.bsky.social · 03/12/2024
Thanks Val, me too 🙌
000