Sign in

TRAstonDrs

@castltrastondrs.medsky.network
10K followers 1.9K following 21K posts

"Not all those who wander are lost" JR Tolkien #Clinicalresearcher #DrugDevelopment #Clinicaltrials & Registration 🧬🔬📚🔎🦠🧫 📌 Melbourne 🇦🇺 Oxford 🇬🇧& 🏴󠁧󠁢󠁳󠁣󠁴󠁿 #MedSky🧪

PostsRepliesMedia
Reposted by TRAstonDrs
European Medicines Agency @ema.europa.eu · 9h
🧪 EMA will develop a roadmap by end-2026 to drive change in how women’s health is considered in medicines development and regulation. It follows a workshop with 100+ experts and stakeholders. Read more: www.ema.europa.eu/en/news/wome... #medsky #womenshealth
ema.europa.eu
Women are missing from medicines development: EMA’s roadmap for change | European Medicines Agency (EMA)
10 priorities proposed to drive change in medicines for women’s health
01811
TRAstonDrs @castltrastondrs.medsky.network · 10h
Let me sit here, on the threshold of two worlds. Lost in the eloquence of silence Rumi
The park & moring
040
TRAstonDrs @castltrastondrs.medsky.network · 11h
Colours of the morning
010
TRAstonDrs @castltrastondrs.medsky.network · 14h
#Medsky🧪 #IDsky #Neurosky #publichealth #Vaccinesmatter The hidden danger of #COVID infection extends beyond the brain and is more profound than the iceberg – most people are not remembering of these . 🧨Acute neurological manifestations in #COVID are linked to complement activation & glia-promoted
120
TRAstonDrs @castltrastondrs.medsky.network · 16h
#Medsky🧪 #pedsky #publichealth @natureportfolio.nature.com Vaping has ‘alarming’ risks for children.The use of e-cigarettes — vapes — is on the rise, but it carries serious health risks for children… www.nature.com/articles/d41...
nature.com
Vaping in childhood has bigger health risks than we’d thought
Use of e-cigarettes makes it more likely that young people will experience mental-health disorders and take up smoking. Governments must act.
042
TRAstonDrs @castltrastondrs.medsky.network · 19h
#Medsky🧪 #oncosky #Microsky #publichealth #vaccinesmatter @sciam.bsky.social Want to protect yourself against cancer? Get vaccinated Many cancers associated with infection are preventable . An estimated 1 in 8 cancer cases… www.scientificamerican.com/article/one-...
scientificamerican.com
One in eight new cancers are likely caused by infections—there’s an easy way to protect yourself
Many cancers associated with infection are preventable
176
TRAstonDrs @castltrastondrs.medsky.network · 20h
#Medsky🧪 #IDsky #pharmsky #publichealth #vaccinesmater #LongCOVID is an ongoing health condition that may occur after being infected with the #SARSCoV2 virus.🦠 can still be detected in the bodies of some people with LC. 🧪A clinical trial for LC found that treating patients
140
TRAstonDrs @castltrastondrs.medsky.network · 29/09/2026
#Medsky🧪#Neurosky #publichealth Chronic subdural hematomas (cSDH) are among the most common neurosurgical pathologies. Older adults also often have comorbidities treated with anticoagulant and antiplatelet (ACAP) medications. Managing clinicians frequently must weigh the benefits.
140
Reposted by TRAstonDrs
The Lancet Infectious Diseases @thelancetinfdis.bsky.social · 29/09/2026
New Review Methodological quality and risk of bias in non-randomised comparative effectiveness studies of invasive mould infections: a systematic review www.thelancet.com/journals/lan...
thelancet.com
Methodological quality and risk of bias in non-randomised comparative effectiveness studies of invasive mould infections: a systematic review
Many treatment recommendations for invasive mould infections, particularly those caused by rare moulds, rely on non-randomised comparative effectiveness research (CER), which is vulnerable to design a...
033
Reposted by TRAstonDrs
Craig McGowan @craigmcg.bsky.social · 27/09/2026
That Tree. Early in my reconnection with photography and my first digital camera I shot the Wānaka tree. Sadly these days it possesses less limbs than in this image, but continues to sit proudly in the water. The LE image was taken in the last light of the day. #photography
1531856
TRAstonDrs @castltrastondrs.medsky.network · 29/09/2026
It doesn't matter how many languages you speak, speaking the language of the heart is what matters. Rumi Just be kind today
The boy is cuddling his pet chicken.
2366
TRAstonDrs @castltrastondrs.medsky.network · 29/09/2026
#Medsky🧪 #IDsky #microsky #publichealth In this study, increasing doses of antimicrobial prophylaxis did not improve SSI (surgical site infection )prevention. @eclinicalmed.bsky.social www.thelancet.com/journals/ecl...
thelancet.com
Safety of routine antimicrobial prophylaxis for surgery (SAPPHIRE): a prospective multi-centre cohort study
In this study, increasing doses of antimicrobial prophylaxis did not improve SSI prevention. Antimicrobial side effect rates were much higher than expected, especially among patients receiving more do...
110
TRAstonDrs @castltrastondrs.medsky.network · 29/09/2026
Long COVID remains a complex, multisystem disorder affecting an estimated 400 mil people globally, characterized by persistent systemic failures in understanding, diagnosis, and treatment. The condition carries an estimated annual economic toll of $1 trillion
141
TRAstonDrs @castltrastondrs.medsky.network · 29/09/2026
#Medsky🧪 #pedsky #IDsky #vaccinesmatter #obsky #neurosky #publichealth Are #congenitalTORCH ( #toxoplasmosis, #syphilis, #rubella, #cytomegalovirus, or #herpessimplex) infections associated with neurodevelopmental and psychiatric outcomes?
110
TRAstonDrs @castltrastondrs.medsky.network · 28/09/2026
The only effective solution against evil and violent people is good people more skilled in violence. Miyamoto Musashi
050
TRAstonDrs @castltrastondrs.medsky.network · 28/09/2026
If everything around you is looking dark, look again, you might be the light… Rumi
The morning light reflected on the loch. Look up and take in the Autumn sky. The morning light, the autumn sky and the perspective. Enjoying a refreshing morning run.
0102
TRAstonDrs @castltrastondrs.medsky.network · 28/09/2026
#Medsky🧪 #publichealth A Little-known arm of the immune system responds to lipids, with CD1 protein driving reactions to 🐝 stings, bacteria & possibly poison ivy could be key to better vaccines, cancer therapies . @aaas.org www.science.org/content/arti...
science.org
Little-known arm of immune system could be key to better vaccines, cancer therapies
The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy
062
Reposted by TRAstonDrs
Internal Medicine Journal @the-imj.bsky.social · 28/09/2026
Iron infusions aren’t always benign. Hypophosphataemia is common, overlooked, and can be severe. This review breaks down the why, who, and what to do next. doi.org/10.1111/imj.70576 #OpenAccess #Review @theracp.bsky.social
042
Reposted by TRAstonDrs
haysamrady @sodatroubles.bsky.social · 28/09/2026
Prevalence, risk factors, and the screening value of basal cortisol for adrenal insufficiency after corticosteroid therapy in children with idiopathic nephrotic syndrome #nephsky #nephrology link.springer.com/article/10.1...
link.springer.com
Prevalence, risk factors, and the screening value of basal cortisol for adrenal insufficiency after corticosteroid therapy in children with idiopathic nephrotic syndrome - Clinical and Experimental Ne...
Background Children with idiopathic nephrotic syndrome (INS) receive prolonged glucocorticoids that can suppress the hypothalamic–pituitary–adrenal (HPA) axis and cause adrenal insufficiency (AI). We ...
021
TRAstonDrs @castltrastondrs.medsky.network · 28/09/2026
#Medsky🧪 #publichealth Aging does not appear to follow the same molecular script for everyone, according to an 8-year study of more than 300 women. The findings @science.org reveal that individual molecular trajectories of aging can diverge www.science.org/doi/10.1126/...
science.org
Longitudinal dynamics of gene expression and metabolomics in an aging population cohort
Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudi...
151
TRAstonDrs @castltrastondrs.medsky.network · 27/09/2026
#Medsky🧪 #IDSky #publichealth #Vaccinesmatter Emerging clinical data indicates that POSH characterised by a drop 🩸 CO₂ upon standing is a highly prevalent, distinct physiological marker of #LongCOVID that frequently occurs without the traditional heart rate spikes seen in POT Syndrome
163
Reposted by TRAstonDrs
The Conversation U.S. @us.theconversation.com · 27/09/2026
Scientific studies often say researchers “controlled” for certain variables. But what does that actually mean? A statistician explains what “control” means and how it can help you judge reports of new research:
theconversation.com
What does it mean to ‘control’ for variables in a scientific study? A statistician explains
Understanding what a ‘control’ is can help you decide for yourself how insightful new studies are.
01611
TRAstonDrs @castltrastondrs.medsky.network · 27/09/2026
The world exists as you perceive it. It is not way you see, it is how you see it. Rumi
Captured the moon from the window last night After a 526-miles drive from 🏴󠁧󠁢󠁳󠁣󠁴󠁿 to Oxford, the view of the sky is incredibly rewarding.  It’s a welcome sight and a worthy reward for the journey home.The Ruby evening sky A brilliant luminous view makes you realise nature has much to offer.
180
Reposted by TRAstonDrs
Mike Honey @mikehoney.bsky.social · 27/09/2026
I took a look at the data on #ME/CFS for Australia. Hospital separations for "G04 Encephalitis, myelitis and encephalomyelitis" have been growing strongly since around 2015. Growth slowed in the early years of the pandemic and then accelerated from 2023 onwards.
48635
Reposted by TRAstonDrs
Journal of Human Immunity @jhumimmunity.org · 25/09/2026
Human inborn errors of the phagocyte respiratory burst: chronic granulomatous disease and beyond. New review from Anna-Lena Neehus @alneehus.bsky.social, Vijay G. Sankaran @bloodgenes.bsky.social, Jean-Laurent Casanova @casanovalab.bsky.social, and Jacinta Bustamante: rupress.org/jhi/article/...
032
TRAstonDrs @castltrastondrs.medsky.network · 27/09/2026
Measles is a highly contagious infectious disease caused by the #measles virus, in the genus Morbillivirus and the family Paramyxoviridae. Its transmission is characterised by an exceptionally high basic reproduction number (R0), typically estimated to range from 12 to 18,
141
TRAstonDrs @castltrastondrs.medsky.network · 26/09/2026
#Medsky🧪 #oncosky #publichealth The study identifies a direct cellular mechanism linking dietary fat, lipid metabolism, and the spread of #colorectalcancer (CRC) to other organs, primarily the liver .
1102
Reposted by TRAstonDrs
Rhea Liang @liangrhea.bsky.social · 23/09/2026
'A survey of Australians as young as 13 found misogyny can predict extremist violence more strongly than ideology, religion or time online.' The under-16 social media ban won't address this. We have to start having the necessary difficult conversations to challenge gendered disrespect everywhere.
pursuit.unimelb.edu.au
Hostile attitudes toward women are driving extremism in young Australians
A University of Melbourne survey of Australians as young as 13 found misogyny can predict extremist violence more strongly than ideology, religion or time online.
59556
Reposted by TRAstonDrs
Simonetta Gribaldo @sgribaldo.bsky.social · 23/09/2026
Interested in #archaea, #methane, #cell-envelopes? New paper out @nature.com ! We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description www.nature.com/articles/s41... #MicroSky 🧵👇
nature.com
1412374
TRAstonDrs @castltrastondrs.medsky.network · 26/09/2026
#Medsky🧪 #microsky Meet the parents Microorganisms that might descend from the lineage that gave rise to all complex life .The Asgard archaea were discovered in 2015 from DNA in sediments plucked from the bottom of the North Atlantic. @nature.com www.nature.com/articles/d41...
nature.com
These bizarre, much-coveted microbes are revealing the origins of complex life
Researchers are racing to culture a menagerie of exotic organisms and finding lots of surprises along the way.
141
TRAstonDrs @castltrastondrs.medsky.network · 26/09/2026
#Medsky🧪 #IDsky #Microsky #publichealth EBV is extremely common. Carried through saliva, #herpesvirus can be easily transmitted by sharing drinks, food utensils, or kissing. It's the virus that most commonly causes mononucleosis (mono) @natureportfolio.nature.com www.nature.com/articles/s41...
nature.com
EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse - Nature Medicine
Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS r...
183
TRAstonDrs @castltrastondrs.medsky.network · 26/09/2026
As I walk’d by myself, I said to mysel,And myself said again to me; Look weel to thyself, or not to thyself, There's nobody cares for thee… Robert Burns Cloncaird Castle, a 16th-century in the middle of nowhere. As I Walk to reflect
050
Reposted by TRAstonDrs
CIDRAP @cidrap.bsky.social · 23/09/2026
Study: More than 1️⃣ in 10 US healthcare workers report ongoing long-COVID symptoms Older age, female sex, multiple underlying health conditions, and multiple COVID infections were also associated with persistent symptoms. Read more: bit.ly/4xGJkjW
Tired nurse rests against a column in a busy hospital corridor
14932
TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026
#Medsky🧪 #IDsky #publichealth One of the most challenging clinical encounters in ID is the patient with persistent fatigue and other disabling symptoms after an infection. Some of these patients meet criteria for ME/CFS but whatever label we use, the story is often strikingly similar in #Longcovid…
180
TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026
I gorge myself on dreams of stories and secrets… Nothing remains as it is it changes, and me with it Rose Ausländer
The vibrant colours of water lily leaves are on full display. The guarding 🐑 Castle in the wood An evening in the woods as the sun sets.
020
Reposted by TRAstonDrs
NEJM.org @nejm.org · 22/09/2026
Our latest video in partnership with @glaucomflecken.bsky.social summarizes the ALLEGORY trial that evaluated the efficacy and safety of obinutuzumab when added to standard therapy in adults with active systemic lupus erythematosus. Read the full study for free: nej.md/DrG49 #rheumatology
0667
TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026
#Medsky 🧪 “Roomba” Digital witnesses are already testifying. In short, household data can convict, exonerate or mislead. That makes digital forensics indispensable and demands careful guardrails.
021
TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026
#Medsky🧪 #IDsky #vaccinesmatter #immunosky #publichealth The destructive nature of #COVID infection & the devastating effects of #longCOVID stem from its involvement in multiple functional signalling pathways related to host immunity. This disruption cripples our once mighty immune system.
141
TRAstonDrs @castltrastondrs.medsky.network · 22/09/2026
Having driven about 500 miles, the view is definitely worth it. Castle in the woods
Water lily is still striving in the autumn Horses & sky , the view so gorgeous..,The water lilies reflect the copper and spice hues of autumn.  It’s quite different from typical English autumn – far too warm!
170
TRAstonDrs @castltrastondrs.medsky.network · 19/09/2026
When a scientist runs an experiment, there are all sorts of results that could happen. Some results are positive and some are negative, but all of them are data points... And that's exactly how a scientist treats failure: as another data point. – James Clear
3101
TRAstonDrs @castltrastondrs.medsky.network · 19/09/2026
The best way out is always through. – Robert Frost It’s time to go off grid and time for pause ,to reflect and debrief…
Scottish highland Seeing life through the patterns of autumn fields A familiar longing for home on my mountain bike…Sunlight streams through the mountain chasm.
1131
Reposted by TRAstonDrs
Shematologist, MD @shematologist.medsky.social · 16/09/2026
So excited to share our new @ash.hematology.org iron deficiency diagnosis guidelines TLDR: Adults 🩸ferritin < 30 diagnostic of ID 🩸ferritin < 50 w/symptoms or risk factors diagnostic of ID Kids 🩸ferritin <20 diagnostic of ID Get your lab intervals updated! tinyurl.com/ASHirondx
tinyurl.com
American Society of Hematology 2026 guidelines for diagnosis of iron deficiency
Background: Iron deficiency is the most common micronutrient deficiency, and when untreated progresses to anemia. Existing guidance on the diagnostic crite
1512647
TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026
Reality, with its unpleasant sides, one cannot deny it. Perhaps there is, nevertheless, a way to “turn it around” to see it differently In a better light... any given morning in September
A morning run before the dawn Autumn morning Here comes the sunLife begins with the reflection of the sun
130
TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026
#Medsky🧪 #Neurosky #publichealth In a 2025 @sciimmunology.bsky.social Review, The study discussed how interactions between the nervous and immune systems could impact neurological disorders and allergy-related behaviors like food avoidance. www.science.org/doi/10.1126/...
Fig. 1. Interactions between the nervous system and type 2 immunity occur across multiple organs depending on the context of allergic triggers or injury.
The nervous system comprises the CNS and associated sensory nerves (blue) and the autonomic nervous system, which includes sympathetic and parasympathetic nerves (red) and the ENS (purple). The immune system is composed of cells that span the entire body. This includes the meningiocranial immune system, which comprises immune cells important for neural development, brain repair, and brain border protection. Repeated exposure to allergens at mucosal sites (for example, lung, skin, and gut) can trigger local type 2 immunity. Type 2 immune cells signal to neurons across the periphery and brain through cytokines, whereas neurons signal to immune cells via neurotransmitters and neuropeptides. This is not an exhaustive list of cellular players, given that other tissue resident cells (e.g., fibroblasts and glial cells) may also respond to these signals.
CREDIT: A. FISHER/SCIENCE IMMUNOLOGY
1145
TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026
#Medsky💉 #IDsky #Episky #publichealth @cidrap.bsky.social This study concluded that the current influenza symptom-based isolation guidelines are biologically supported by shedding kinetics, but emphasized that the 5-day post-isolation precaution phase www.cidrap.umn.edu/influenza-ge...
cidrap.umn.edu
Few people with the flu isolate for the recommended period
2147
TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026
#Medsky🧪 #Neurosky #publichealth More than 1,000 overlooked microproteins in human brain tissue have been detected, including some that are altered in #Alzheimersdisease @nature.com www.nature.com/articles/d41...
nature.com
Map of brain ‘microproteins’ could offer new clues to Alzheimer’s disease
Researchers detect more than 1,000 overlooked microproteins in human brain tissue, including some that are altered in Alzheimer’s disease.
050
Reposted by TRAstonDrs
Delthia Ricks @dricks.bsky.social · 17/09/2026
The latest unvaccinated person to die in Pennsylvania's epidemic was an 18-year-old who developed disseminated encephalomyelitis, a rare measles complication. The vax prevents measles. Period. Measles is a highly contagious viral respiratory illness spread via airborne droplets. RFKjr is a lunatic👇
32818
TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026
#Medsky🧪 #IDsky #microsky #pedsky #Vaccinesmatter #publichealth Not only #COVID but Non- #COVID respiratory viral infections (RVIs) are consistently associated with post-acute multi-organ sequelae, particularly following severe infection. onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
<em>Respirology</em> | APSR Respiratory Medicine Journal | Wiley Online Library
Respiratory viral infections (RVIs) affect millions annually, yet long-term consequences outside COVID-19 are poorly defined. Post-acute sequelae, encompassing persistent or new physical, cognitive, ...
131
TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026
#Medsky🧪 #immunosky #pedsky #pharmsky #publichealth @JAMA The findings of this study suggest that #nirsevimab is highly effective in preventing severe #RSV disease that requires hospital-based care and can substantially reduce the burden of severe RSV disease. jamanetwork.com/journals/jam...
jamanetwork.com
Nirsevimab and Respiratory Syncytial Virus–Related Hospitalizations in Infants
This case-control study estimates the effectiveness of nirsevimab for preventing hospitalizations related to respiratory syncytial virus (RSV) among infants in Ontario and Quebec, Canada, during the 2...
031
TRAstonDrs @castltrastondrs.medsky.network · 17/09/2026
@cnn.com’s analysis is fascinating. Once an aura of invincibility fades political authority can erode rapidly and a blaze of glory eventually becomes a slow-burning ash. edition.cnn.com/2026/09/16/p...
edition.cnn.com
Analysis: Trump’s frustration hits a boiling point with loss after loss | CNN Politics
Donald Trump is boiling with frustration after a spate of political blows weakened his presumption of dominance in Washington and abroad.
120