The issues faced by scientist-couples can be multiplied once they start a family, making conference travel a logistical trial.

Oxford Cancer is delighted to announce the appointment of Professor Adam Mead as Director, joining Professors Mark Middleton and Tim Elliott in leading Oxford’s interdisciplinary cancer research commu...

Professor Adam Mead is joining Professor Alison Simmons as a Deputy Director of the WIMM in May 2026.

Shen et al. report comBO, a combined human bone and bone marrow model that integrates osteolineage, vascular, stromal, and hematopoietic compartments in a single hiPSC-derived organoid system. comBO s...

This study analyses whole-genome sequencing data of cancer samples from 10,983 patients and explores relationships among mutational signatures, various biomarkers and clinical outcomes.

We're excited to announce that we're looking for a postdoctoral research to join our team!

We are seeking a postdoctoral Research Associate to work on an exciting new multi-disciplinary project studying B-cell acute lymphoblastic leukaemia (B-ALL). The project is a collaboration between Dr

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

This Review focuses on epithelial–mesenchymal crosstalk and how these interactions shape development, health and disease in the intestinal mucosa. The dynamic nature of this ecosystem is highlighted, ...

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for...

Help Abdullah Khan raise money to support Bone Cancer Research Trust

The plasticity of cancer-associated fibroblasts (CAFs) refers to their ability to adopt a spectrum of distinct phenotypes or states in response to dynamic changes within the tumor microenvironment (TME). Recent advances in single-cell technologies have enabled detailed characterization of the heterogeneity and spatial complexity of CAF subpopulations across multiple tumor types. Notably, CAF subtypes undergo dynamic transitions during tumor progression and under therapy pressure. This review systematically summarizes the current knowledge on CAF plasticity shaped by both intrinsic and extrinsic factors, delineates research gaps, and highlights CAF phenotypic switching as a potential therapeutic opportunity.

We are really excited to be advertising for an enthusiastic and committed post doc to work on a wet lab/dry lab project applying systems biology to mulitple diseases. Deadline 29th June.

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

CREBBP mutations in B-cell acute lymphoblastic leukemia (B-ALL) are linked to poor prognosis and chemoresistance. Here, the authors show that genetic or pharmacological inactivation of CREBBP sensitiz...

Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...

Stem cells are a promising source for cellular therapies across many diseases and tissues. Their inherent ability to differentiate into other cell types has been the focus of investigation over decade...

The CRC-STARS team will learn more about how bowel cancer behaves so that it can potentially be treated in a more personalised way