Researchers have discovered that some human blood stem cells retain a lasting “memory” of inflammation, a finding that could help explain links between ageing, chronic disease, and blood cancers

Three MRC WIMM researchers have won a £5,000 prize at a Health x AI Hackathon held at Google’s London headquarters, after developing an AI-powered tool designed to identify delays in patient care.

Spatial transcriptomics (ST) maps gene expression within intact tissues, but its cost and technical complexity limit broad adoption. A growing body of deep-learning methods now seeks to infer ST direc...

Great science rarely happens in isolation.In this video researche...

A new form of CAR T cell therapy has been designed to find and destroy the cancer-driving cells responsible for a group of blood cancers known as myeloproliferative neoplasms (MPNs), while leaving hea...

YouTube video by Radcliffe Department of Medicine Oxford University

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Thomas Milne and Dominique Bonnet on their latest articles published in volume 147 issue 24 of Blood. Dr. Milne discusses how ...

Congratulations to Professor de Bruijn, who has been awarded funding from the UKRI Medical Research Council to investigate how the first blood stem cells formed in the embryo acquire their exceptional...

Germinal centers (GCs) are specialized microenvironments in which B cells undergo affinity maturation through iterative cycles of somatic hypermutation, proliferation and selection, generating antibo...

No one builds a scientific career alone.In this video researchers...

Congratulations to Professor Psaila, who has received the 2026 Janet Rowley Award from the International Society for Experimental Hematology, in recognition of her outstanding contributions in the field of experimental haematology.

Agonistic antibodies initiate signalling by the receptors they target, mimicking the activities of native ligands. This Review discusses the clinical successes and failures of agonistic antibodies and explains how recent mechanistic insights should broaden the scope and improve the safety and efficacy of immunotherapies based on these agents.

This summer, researchers at the MRC WIMM have taken part in a variety of public engagement activities, leading a stand at Cheltenham Science Festival and welcoming students for the Institute's summer work experience programme.

Congratulations to Professor Patel, who has received the Buchanan Medal, which recognises distinguished contributions to the biomedical sciences.

A new study led by the Ho Group has uncovered a striking immune signature that may help explain what happens in the early stages of idiopathic pulmonary fibrosis (IPF), a serious condition that causes scarring of the lungs and makes breathing difficult.

What does sustainability look like in a research environment?In t...

MDA5 detects double-stranded RNA during viral infections. This work shows that MDA5 binds aberrant host RNA induced during viral infection. Rescue of aberrant cytoplasmic RNA during infection abrogate...

During embryonic development, the specification of hematopoietic stem cells (HSCs) and progenitor cells (HPCs) critically depends on the transcription factor Runx1. Anselmi et al. describe a Runx1 enh...

Learning does not stop after a degree or a new job. It is an essent...

High-grade serous ovarian cancers (HGSC) are refractory to immunotherapy, and a comprehensive characterization of the immune landscape at these lesions is lacking. Here, the authors employ single-cell RNA and TCR sequencing of patient-derived tissues to characterize T cell clonality and differentiation during tumor evolution. Tissue-resident memory-like T cells in early lesions display tumor reactivity, exhibit reduced exhaustion, and are implicated in early immune surveillance, and could be leveraged for the design of immunomodulatory therapeutic approaches.

Science has the greatest impact when it reaches beyond the laborato...

Here, Zhang et al. identify a transgene-independent marker combination that prospectively isolates platelet-biased hematopoietic stem cells with high purity, overcoming a key limitation in the field, ...

Poly(ADP-ribose) polymerase inhibitors (PARPi) exploit homologous recombination deficiency (HRD) in BRCA1/2-mutated cancers to induce synthetic lethality[1][1]–[3][2]. PARPi also kill cancer cells lac...

YouTube video by Unravelling T Cell Recognition

Dr Sumana Sharma is one of the founding partners of a major new pan-European initiative that aims to transform how scientists identify and target cancer's weaknesses, moving beyond simply mapping canc...

Congenital dyserythropoietic anaemia type I is caused by mutations in CDAN1 or CDIN1, but the molecular basis of disease is unclear. Here, the authors show that Codanin-1 and CDIN1 form an RNA nucleas...

YouTube video by MRC Weatherall Institute of Molecular Medicine