Murray et al. introduce “transformative neuropathology” through dynamic, technology-integrated approaches to accelerate tissue-based discoveries and offer actionable strategies to strengthen brain ban...

Neurofibrillary tangles are dynamic neuropathologic hallmarks of Alzheimer's disease with a hypothesized lifespan morphologically-defined by three maturity levels: pretangles, mature tangles, and ghos...

Human autoantibody-mediated diseases associated with a single autoantigenic target provide several valuable opportunities for precision medicine.1 The impl

An educational course about computational psychiatry from UZH & ETH Zurich.

A crowd-sourced site. Health and Well-being. National Security. Prosperity.

In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Experts say reading has positive effect on reducing stress and improving cognitive ability

The Rainwater Charitable Foundation (RCF) is proud to award Bess Frost, Ph.D., Brown University, with the 2025 Rainwater Prize for Innovative Early-Career Scientist of $200,000. The Rainwater PrizeTM ...

Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...

Dr. Joe Sirven explores the fight against genetic destiny and aging.

Assistant Professor (tenure track) - Chromatin Regulation, Genetic Regulatory Mechanisms, Epigenetics, Epigenomics

Nature Reviews Genetics, Published online: 28 March 2025; doi:10.1038/s41576-025-00828-zAdvances in long-read sequencing are driving the implementation of these technologies for transcriptome profiling. The authors provide a comprehensive guide to long-read RNA sequencing, including experimental and computational tools, current applications, challenges and opportunities.

Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer’s disease (AD). The maturity level of neurofibrillary tangles ...

Background Tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. Despite extensive research, the mec...

This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...

This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...

Hippocampal atrophy on magnetic resonance imaging is an important biomarker in Alzheimer's disease (AD). While hippocampal atrophy was thought to result from tau tangles in AD, different neuropathol...