García-Torralba et al. critically discuss key immunobiological features of human breast cancer, focusing on disease heterogeneity and its implications for the development of improved therapeutic optio...

García-Torralba et al. critically discuss key immunobiological features of human breast cancer, focusing on disease heterogeneity and its implications for the development of improved therapeutic optio...

García-Torralba et al. critically discuss key immunobiological features of human breast cancer, focusing on disease heterogeneity and its implications for the development of improved therapeutic optio...

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Petroni et al. report that the infiltration of IL-17A-secreting γδ T cells in the tumor microenvironment coupled with the accumulation of immunosuppressive macrophages is associated with resistance to...

Nature Reviews Immunology - Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability...

Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...

Mitochondrial fitness is critical for effector CD8+ T cell responses against cancer. In this issue of Cancer Cell, Ma et al. delineate a novel mechanism linking defects in mitochondrial metabolism as ...