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Na Zhao

@zhaonaa.bsky.social

162 followers 123 following 1 posts

Associate Professor | Department of Neuroscience | Mayo Clinic www.mayo.edu/research/labs/neurobio…

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Na Zhao @zhaonaa.bsky.social · 20/03/2025

Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social

Reposted by Na Zhao

Neuron @cp-neuron.bsky.social · 19/03/2025

APOE genotype determines cell-type-specific pathological landscape of Alzheimer’s disease

Using single-nucleus RNA sequencing on post-mortem brains from control subjects and Alzheimer’s disease patients, Li et al. revealed APOE-genotype-specific molecular alterations across distinct brain cell types associated with AD. This study offers a…