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Professor Sarosh Irani

@mayo-aing.bsky.social
115 followers 64 following 13 posts

Professor of Neurology and Neurosciences at Mayo Clinic, Florida. Ex-Oxford. Autoantibodies and Lymphocytes which affect the nervous system. Towards improved diagnosis and cure. Autoantibodies, B cells, T cells, antigen and immunotherapies

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Professor Sarosh Irani @mayo-aing.bsky.social · 07/06/2025
Heard it before??? It’s not stridor but an inspiratory noise which myself and @dubeydiv observed in patients with #iglon5 #antibodies ja.ma/3HkZD1y
ja.ma
A Distinctive Inspiratory Noise in IgLON5-Antibody Disease
This case series describes a distinctive inspiratory noise observed during sleep in patients with IgLON5-antibody disease.
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Professor Sarosh Irani @mayo-aing.bsky.social · 03/06/2025
academic.oup.com/brain/articl... My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!
academic.oup.com
Models of autoantibody mediated diseases: actively nearing the human gold standard
Human autoantibody-mediated diseases associated with a single autoantigenic target provide several valuable opportunities for precision medicine.1 The impl
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Professor Sarosh Irani @mayo-aing.bsky.social · 30/05/2025
Apologies This link should work pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
Capturing what matters: Patient‐reported LGI1‐ANTibody encephalitis outcome RatiNg scale (LANTERN)
LGI1‐antibody encephalitis (LGI1‐Ab‐E) is a common form of autoimmune encephalitis where most patients demonstrate ‘good’ clinician‐rated outcomes. However, more targeted questionnaires reveal numerou...
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Reposted by Professor Sarosh Irani
Nuffield Department of Clinical Neurosciences @ndcnoxford.bsky.social · 30/04/2025
Many congratulations to Professor Irani and co-authors for winning the prestigious 2024 PNAS Cozzarelli Prize in Biomedical Science. 👏🧠 The winning paper was a collaboration between NDCN, The Department of Statistics, and the Mayo Clinic in Florida.
Binding of live hippocampal neurons by monoclonal antibodies created from a cerebrospinal fluid plasmablast extracted from an encephalitis patient
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Professor Sarosh Irani @mayo-aing.bsky.social · 09/03/2025
Reminder to all interested in #autoimmune #neurology Please join us ce.mayo.edu/neurology-and-… For great weather, faculty talks and networking….. This will be a small, focused meeting for you to develop your knowledge and skills in #autoimmune #neurology
ce.mayo.edu
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Professor Sarosh Irani @mayo-aing.bsky.social · 28/02/2025
onlinelibrary.wiley.com/doi/full/10.10… Here is the first PROM (patient reported outcome measure) for patients with #LGI1 antibody #encephalitis Hopefully a major inroad to measuring this disease more carefully 👍 We hope this will help patients in routine practice, and in trials
onlinelibrary.wiley.com
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Professor Sarosh Irani @mayo-aing.bsky.social · 08/02/2025
#world #encephalitis #day #america 🇺🇸 #WEDA is today!! On the Mayo JAX campus @MayoClinic @MayoClinicNeuro Kicked off by Philippa Chapman of encephalitis international
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Reposted by Professor Sarosh Irani
Professor Sarosh Irani @mayo-aing.bsky.social · 03/02/2025
In 3 months (and zero days), we have the inaugural @MayoClinic #florida #autoimmune #neurology meeting. 1.5 days of great speakers and 0.5 days to spend on the beautiful Jacksonville beach 🏖️ Please sign up now ✍️ ce.mayo.edu/neurology-an...
ce.mayo.edu
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Professor Sarosh Irani @mayo-aing.bsky.social · 03/02/2025
In 3 months (and zero days), we have the inaugural @MayoClinic #florida #autoimmune #neurology meeting. 1.5 days of great speakers and 0.5 days to spend on the beautiful Jacksonville beach 🏖️ Please sign up now ✍️ ce.mayo.edu/neurology-an...
ce.mayo.edu
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Professor Sarosh Irani @mayo-aing.bsky.social · 19/01/2025
Our new CASPR2 paper is out in Annals Neurology 🤩 Headlines: Patients have neuropathic pain & fatigue as their main long term complaints which determine QoL. 😰 These are NOT immunotherapy responsive. 👩🏾‍⚕️💊 We also report other nuggets in this thread 🧵 ⬇️ onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Immunotherapy‐Resistant Neuropathic Pain and Fatigue Predict Quality‐of‐Life in Contactin‐Associated Protein‐Like 2 Antibody Disease
The long-term clinical outcomes and associated prognostic factors in contactin-associated protein-like 2 (CASPR2)-antibody diseases are unknown. A total of 75 participants with CASPR2 antibodies were...
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Professor Sarosh Irani @mayo-aing.bsky.social · 14/01/2025
Very pleased to see this online @NeuroCellPress With colleagues at @MayoClinicNeuro @MayoFL_NeuroRes @MayoClinic Rochester, we summarise state of the art (and some history 😃) in autoimmune neurology…..ENJOY!! dlvr.it/THL45K
dlvr.it
Toward curing neurological autoimmune disorders: Biomarkers, immunological mechanisms, and therapeutic targets
This article by Segal et al provides a comprehensive overview of immunopathogenic mechanisms of autoimmune neurological disorders, focusing on the interplay between humoral and cellular immunity, rece...
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